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    Gtf2h4 general transcription factor 2H subunit 4 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 294236, updated on 5-Mar-2024

    Summary

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    Official Symbol
    Gtf2h4provided by RGD
    Official Full Name
    general transcription factor 2H subunit 4provided by RGD
    Primary source
    RGD:1303309
    See related
    AllianceGenome:RGD:1303309
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable RNA polymerase II general transcription initiation factor activity and double-stranded DNA binding activity. Predicted to be involved in nucleotide-excision repair; phosphorylation of RNA polymerase II C-terminal domain; and transcription by RNA polymerase II. Predicted to be located in nuclear speck. Predicted to be part of core TFIIH complex portion of holo TFIIH complex and transcription factor TFIID complex. Orthologous to human GTF2H4 (general transcription factor IIH subunit 4). [provided by Alliance of Genome Resources, Apr 2022]
    Annotation information
    Annotation category: suggests misassembly
    Expression
    Biased expression in Thymus (RPKM 44.7), Heart (RPKM 31.6) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Gtf2h4 in Genome Data Viewer
    Location:
    20p12
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 20 NC_086038.1 (3076110..3081805)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 20 NC_051355.1 (3071328..3076990)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 20 NC_005119.4 (3582688..3588373)

    Chromosome 20 - NC_086038.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134483849 Neighboring gene hypothetical LOC100310783 Neighboring gene discoidin domain receptor tyrosine kinase 1 Neighboring gene uncharacterized LOC134483850 Neighboring gene valyl-tRNA synthetase 2, mitochondrial Neighboring gene surfactant associated 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Cloning and characterization of p52, the fifth subunit of the core of the transcription/DNA repair factor TFIIH. Marinoni JC, et al. EMBO J, 1997 Mar 3. PMID 9118947, Free PMC Article
    2. A history of TFIIH: two decades of molecular biology on a pivotal transcription/repair factor. Egly JM, et al. DNA Repair (Amst), 2011 Jul 15. PMID 21592869
    3. Near-atomic resolution visualization of human transcription promoter opening. He Y, et al. Nature, 2016 May 19. PMID 27193682, Free PMC Article
    4. Immunoaffinity purification and functional characterization of human transcription factor IIH and RNA polymerase II from clonal cell lines that conditionally express epitope-tagged subunits of the multiprotein complexes. Kershnar E, et al. J Biol Chem, 1998 Dec 18. PMID 9852112
    5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Clone Names

    • MGC156549

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables RNA polymerase II general transcription initiation factor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables double-stranded DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in nucleotide-excision repair IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    part_of core TFIIH complex portion of holo TFIIH complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nuclear speck ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of transcription factor TFIID complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of transcription factor TFIIH core complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of transcription factor TFIIH holo complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of transcription factor TFIIH holo complex ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    general transcription factor IIH subunit 4
    Names
    TFIIH transcription/DNA repair factor p52 subunit
    general transcription factor II H, polypeptide 4

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_212501.2 → NP_997666.1  general transcription factor IIH subunit 4

      See identical proteins and their annotated locations for NP_997666.1

      Status: VALIDATED

      Source sequence(s)
      BC127469, CK472761
      UniProtKB/TrEMBL
      Q6MG20
      Conserved Domains (1) summary
      TIGR00625
      Location:19 → 461
      tfb2; Transcription factor tfb2

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086038.1 Reference GRCr8

      Range
      3076110..3081805
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063278998.1 → XP_063135068.1  general transcription factor IIH subunit 4 isoform X1

    2. XM_063278999.1 → XP_063135069.1  general transcription factor IIH subunit 4 isoform X1

    RNA

    1. XR_010060632.1 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

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