Cpeb1 cytoplasmic polyadenylation element binding protein 1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Cpeb1provided by RGD
Official Full Name: cytoplasmic polyadenylation element binding protein 1provided by RGD
Primary source: RGD:1310421
See related: Ensembl:ENSRNOG00000019161 AllianceGenome:RGD:1310421
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Enables mRNA 3'-UTR binding activity. Involved in several processes, including cellular response to lipopolysaccharide; mRNA transport; and regulation of macromolecule biosynthetic process. Located in several cellular components, including centrosome; growth cone; and postsynaptic density. Used to study glioblastoma. Biomarker of portal hypertension and primary biliary cholangitis. Orthologous to human CPEB1 (cytoplasmic polyadenylation element binding protein 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Brain (RPKM 58.1), Testes (RPKM 20.9) and 8 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 1q31

Exon count:: 17

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	1	NC_086019.1 (144709278..144817388, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	1	NC_051336.1 (135300048..135407688, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	1	NC_005100.4 (143171457..143278485, complement)

Chromosome 1 - NC_086019.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Cytoplasmic polyadenylation element-binding proteins (CPEB) are mRNA-binding proteins associated with protein translation that play an important role in development, health, and disease.
Title: The mitochondrial calcium uniporter contributes to morphine tolerance through pCREB and CPEB1 in rat spinal cord dorsal horn.
Identify a mechanism of VEGF overexpression in liver and mesentery that promotes pathologic, but not physiologic, angiogenesis, via sequential and nonredundant functions of CPEB1 and CPEB4.
Title: Sequential Functions of CPEB1 and CPEB4 Regulate Pathologic Expression of Vascular Endothelial Growth Factor and Angiogenesis in Chronic Liver Disease.
Increased NPCs proliferation by down-regulation of CPEB1 resulted in eventual up-regulation of neuronal differentiation with increase in both pre- and post-synaptic proteins
Title: A role of CPEB1 in the modulation of proliferation and neuronal maturation of rat primary neural progenitor cells.
This study demonistrated that in chronic mild stress and acute sleep deprivation condition regulation CPEB expressin in hippocampus.
Title: Post-transcriptional effects and interactions between chronic mild stress and acute sleep deprivation: regulation of translation factor and cytoplasmic polyadenylation element-binding protein phosphorylation.
poly(A) polymerase Gld2, deadenylase PARN, and translation inhibitory factor neuroguidin (Ngd) are components of a dendritic CPEB-associated polyadenylation apparatus
Title: Bidirectional control of mRNA translation and synaptic plasticity by the cytoplasmic polyadenylation complex.
CPEB is downstream of protein kinase Cepsilon in the cellular signaling cascade responsible for priming the induction of hyperalgesia.
Title: Generation of a pain memory in the primary afferent nociceptor triggered by PKCε activation of CPEB.
Results demonstrate for the first time a role for CPEB1 in regulating cell proliferation in the brain.
Title: Cyclin B1 expression regulated by cytoplasmic polyadenylation element binding protein in astrocytes.
The results from the study suggest that CPEB1 is actively involved in the regulation of inflammatory responses in astrocytes, which might provide new insights into the regulatory mechanism after brain injury.
Title: CPEB1 modulates lipopolysaccharide-mediated iNOS induction in rat primary astrocytes.
these results suggest that CPEB1 regulates beta-catenin synthesis in neurons and may contribute to neuronal morphogenesis
Title: Cytoplasmic polyadenylation element-binding protein regulates neurotrophin-3-dependent beta-catenin mRNA translation in developing hippocampal neurons.
CPEB1 mediates protein synthesis in the localization of beta-catenin protein to the leading edge of migrating astrocytes, and has a role in regulating directed cell motility.
Title: CPEB1 regulates beta-catenin mRNA translation and cell migration in astrocytes.

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General gene information

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Markers

Cpeb1 (e-PCR), detects polymorphism
- UniSTS:498263

Cpeb1 (e-PCR), detects polymorphism
- UniSTS:479083

RH131661 (e-PCR)
- UniSTS:214944

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables RNA binding	ISO Inferred from Sequence Orthology more info
enables mRNA 3'-UTR AU-rich region binding	ISO Inferred from Sequence Orthology more info
enables mRNA 3'-UTR AU-rich region binding	ISS Inferred from Sequence or Structural Similarity more info
enables mRNA 3'-UTR binding	IBA Inferred from Biological aspect of Ancestor more info
enables mRNA 3'-UTR binding	IDA Inferred from Direct Assay more info	PubMed
enables mRNA 3'-UTR binding	IEA Inferred from Electronic Annotation more info
enables mRNA binding	ISO Inferred from Sequence Orthology more info
enables mRNA regulatory element binding translation repressor activity	IBA Inferred from Biological aspect of Ancestor more info
enables mRNA regulatory element binding translation repressor activity	ISO Inferred from Sequence Orthology more info
enables mRNA regulatory element binding translation repressor activity	ISS Inferred from Sequence or Structural Similarity more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables ribosome binding	IBA Inferred from Biological aspect of Ancestor more info
enables translation factor activity, RNA binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in cellular response to amino acid stimulus	ISO Inferred from Sequence Orthology more info
involved_in cellular response to amino acid stimulus	ISS Inferred from Sequence or Structural Similarity more info
involved_in cellular response to hypoxia	ISO Inferred from Sequence Orthology more info
involved_in cellular response to hypoxia	ISS Inferred from Sequence or Structural Similarity more info
involved_in cellular response to insulin stimulus	ISO Inferred from Sequence Orthology more info
involved_in cellular response to insulin stimulus	ISS Inferred from Sequence or Structural Similarity more info
involved_in cellular response to lipopolysaccharide	IEP Inferred from Expression Pattern more info	PubMed
involved_in mRNA processing	IEA Inferred from Electronic Annotation more info
involved_in mRNA transport	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of cell population proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of cytoplasmic translation	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of cytoplasmic translation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of cytoplasmic translation	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of translation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of cell migration	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of meiotic cell cycle process involved in oocyte maturation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of neuron projection development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of nitric-oxide synthase biosynthetic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of translation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of translation	ISO Inferred from Sequence Orthology more info
involved_in regulation of mRNA 3'-end processing	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of neuronal synaptic plasticity	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of translation	ISO Inferred from Sequence Orthology more info
involved_in regulation of translation at synapse, modulating synaptic transmission	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within synaptonemal complex assembly	ISO Inferred from Sequence Orthology more info
involved_in translation	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in P-body	IEA Inferred from Electronic Annotation more info
located_in centrosome	IDA Inferred from Direct Assay more info	PubMed
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	ISS Inferred from Sequence or Structural Similarity more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
is_active_in glutamatergic synapse	IDA Inferred from Direct Assay more info	PubMed
is_active_in glutamatergic synapse	ISO Inferred from Sequence Orthology more info
located_in growth cone	IDA Inferred from Direct Assay more info	PubMed
located_in meiotic spindle	ISO Inferred from Sequence Orthology more info
located_in membrane	ISO Inferred from Sequence Orthology more info
part_of messenger ribonucleoprotein complex	IBA Inferred from Biological aspect of Ancestor more info
is_active_in neuron projection	IBA Inferred from Biological aspect of Ancestor more info
located_in neuronal cell body	IDA Inferred from Direct Assay more info	PubMed
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISS Inferred from Sequence or Structural Similarity more info
located_in perinuclear region of cytoplasm	IDA Inferred from Direct Assay more info	PubMed
is_active_in postsynapse	IDA Inferred from Direct Assay more info	PubMed
is_active_in postsynaptic density	IDA Inferred from Direct Assay more info	PubMed
is_active_in synapse	IBA Inferred from Biological aspect of Ancestor more info
located_in synapse	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: cytoplasmic polyadenylation element-binding protein 1

Names: CPE-BP1; CPE-binding protein 1; CPEB; CPEB-1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001106276.1 → NP_001099746.1 cytoplasmic polyadenylation element-binding protein 1

See identical proteins and their annotated locations for NP_001099746.1

Status: PROVISIONAL

Source sequence(s)

CH473980

UniProtKB/Swiss-Prot

P0C279

UniProtKB/TrEMBL

A0A8L2QE04, A6JCF8

Related

ENSRNOP00000072309.2, ENSRNOT00000080925.2

Conserved Domains (4) summary

cd12723
Location:308 → 415

RRM1_CPEB1; RNA recognition motif 1 in cytoplasmic polyadenylation element-binding protein 1 (CPEB-1) and similar proteins

cd12725
Location:426 → 511

RRM2_CPEB1; RNA recognition motif 2 in cytoplasmic polyadenylation element-binding protein 1 (CPEB-1) and similar proteins

pfam16366
Location:503 → 558

CEBP_ZZ; Cytoplasmic polyadenylation element-binding protein ZZ domain

pfam16368
Location:1 → 306

CEBP1_N; Cytoplasmic polyadenylation element-binding protein 1 N-terminus

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086019.1 Reference GRCr8

Range

144709278..144817388 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039105662.2 → XP_038961590.1 cytoplasmic polyadenylation element-binding protein 1 isoform X9

UniProtKB/TrEMBL

A0A8L2QE04

Conserved Domains (4) summary

pfam16366
Location:428 → 483

CEBP_ZZ; Cytoplasmic polyadenylation element-binding protein ZZ domain

pfam16368
Location:1 → 231

CEBP1_N; Cytoplasmic polyadenylation element-binding protein 1 N-terminus

cd12723
Location:233 → 340

RRM1_CPEB1; RNA recognition motif 1 (RRM1) found in cytoplasmic polyadenylation element-binding protein 1 (CPEB-1) and similar proteins

cd12725
Location:351 → 434

RRM2_CPEB1; RNA recognition motif 2 (RRM2) found in cytoplasmic polyadenylation element-binding protein 1 (CPEB-1) and similar proteins
XM_039105656.2 → XP_038961584.1 cytoplasmic polyadenylation element-binding protein 1 isoform X9

UniProtKB/TrEMBL

A0A8L2QE04

Conserved Domains (4) summary

pfam16366
Location:428 → 483

CEBP_ZZ; Cytoplasmic polyadenylation element-binding protein ZZ domain

pfam16368
Location:1 → 231

CEBP1_N; Cytoplasmic polyadenylation element-binding protein 1 N-terminus

cd12723
Location:233 → 340

RRM1_CPEB1; RNA recognition motif 1 (RRM1) found in cytoplasmic polyadenylation element-binding protein 1 (CPEB-1) and similar proteins

cd12725
Location:351 → 434

RRM2_CPEB1; RNA recognition motif 2 (RRM2) found in cytoplasmic polyadenylation element-binding protein 1 (CPEB-1) and similar proteins
XM_063284729.1 → XP_063140799.1 cytoplasmic polyadenylation element-binding protein 1 isoform X10
XM_039105652.2 → XP_038961580.1 cytoplasmic polyadenylation element-binding protein 1 isoform X9

UniProtKB/TrEMBL

A0A8L2QE04

Conserved Domains (4) summary

pfam16366
Location:428 → 483

CEBP_ZZ; Cytoplasmic polyadenylation element-binding protein ZZ domain

pfam16368
Location:1 → 231

CEBP1_N; Cytoplasmic polyadenylation element-binding protein 1 N-terminus

cd12723
Location:233 → 340

RRM1_CPEB1; RNA recognition motif 1 (RRM1) found in cytoplasmic polyadenylation element-binding protein 1 (CPEB-1) and similar proteins

cd12725
Location:351 → 434

RRM2_CPEB1; RNA recognition motif 2 (RRM2) found in cytoplasmic polyadenylation element-binding protein 1 (CPEB-1) and similar proteins
XM_063284707.1 → XP_063140777.1 cytoplasmic polyadenylation element-binding protein 1 isoform X8
XM_063284698.1 → XP_063140768.1 cytoplasmic polyadenylation element-binding protein 1 isoform X6
XM_017588940.3 → XP_017444429.1 cytoplasmic polyadenylation element-binding protein 1 isoform X5

UniProtKB/TrEMBL

A0A8L2QE04
XM_017588939.3 → XP_017444428.1 cytoplasmic polyadenylation element-binding protein 1 isoform X3

UniProtKB/TrEMBL

A0A8L2QE04
XM_008759510.4 → XP_008757732.1 cytoplasmic polyadenylation element-binding protein 1 isoform X2

UniProtKB/TrEMBL

A0A0G2K5E3, A0A8L2QE04

Related

ENSRNOP00000073393.2

Conserved Domains (4) summary

cd12723
Location:346 → 448

RRM1_CPEB1; RNA recognition motif 1 in cytoplasmic polyadenylation element-binding protein 1 (CPEB-1) and similar proteins

cd12725
Location:459 → 544

RRM2_CPEB1; RNA recognition motif 2 in cytoplasmic polyadenylation element-binding protein 1 (CPEB-1) and similar proteins

pfam16366
Location:536 → 591

CEBP_ZZ; Cytoplasmic polyadenylation element-binding protein ZZ domain

pfam16368
Location:45 → 344

CEBP1_N; Cytoplasmic polyadenylation element-binding protein 1 N-terminus
XM_008759509.4 → XP_008757731.1 cytoplasmic polyadenylation element-binding protein 1 isoform X1

UniProtKB/TrEMBL

A0A8L2QE04

Conserved Domains (4) summary

cd12723
Location:346 → 453

RRM1_CPEB1; RNA recognition motif 1 in cytoplasmic polyadenylation element-binding protein 1 (CPEB-1) and similar proteins

cd12725
Location:464 → 549

RRM2_CPEB1; RNA recognition motif 2 in cytoplasmic polyadenylation element-binding protein 1 (CPEB-1) and similar proteins

pfam16366
Location:541 → 596

CEBP_ZZ; Cytoplasmic polyadenylation element-binding protein ZZ domain

pfam16368
Location:45 → 344

CEBP1_N; Cytoplasmic polyadenylation element-binding protein 1 N-terminus
XM_039105670.2 → XP_038961598.1 cytoplasmic polyadenylation element-binding protein 1 isoform X11

Conserved Domains (4) summary

pfam16366
Location:382 → 437

CEBP_ZZ; Cytoplasmic polyadenylation element-binding protein ZZ domain

pfam16368
Location:42 → 209

CEBP1_N; Cytoplasmic polyadenylation element-binding protein 1 N-terminus

cd12723
Location:187 → 294

RRM1_CPEB1; RNA recognition motif 1 (RRM1) found in cytoplasmic polyadenylation element-binding protein 1 (CPEB-1) and similar proteins

cd12725
Location:305 → 388

RRM2_CPEB1; RNA recognition motif 2 (RRM2) found in cytoplasmic polyadenylation element-binding protein 1 (CPEB-1) and similar proteins
XM_063284704.1 → XP_063140774.1 cytoplasmic polyadenylation element-binding protein 1 isoform X7
XM_063284737.1 → XP_063140807.1 cytoplasmic polyadenylation element-binding protein 1 isoform X12
XM_063284692.1 → XP_063140762.1 cytoplasmic polyadenylation element-binding protein 1 isoform X4

UniProtKB/TrEMBL

A0A0G2K2N1
XM_039105664.2 → XP_038961592.1 cytoplasmic polyadenylation element-binding protein 1 isoform X9

UniProtKB/TrEMBL

A0A8L2QE04

Conserved Domains (4) summary

pfam16366
Location:428 → 483

CEBP_ZZ; Cytoplasmic polyadenylation element-binding protein ZZ domain

pfam16368
Location:1 → 231

CEBP1_N; Cytoplasmic polyadenylation element-binding protein 1 N-terminus

cd12723
Location:233 → 340

RRM1_CPEB1; RNA recognition motif 1 (RRM1) found in cytoplasmic polyadenylation element-binding protein 1 (CPEB-1) and similar proteins

cd12725
Location:351 → 434

RRM2_CPEB1; RNA recognition motif 2 (RRM2) found in cytoplasmic polyadenylation element-binding protein 1 (CPEB-1) and similar proteins
XM_039105676.2 → XP_038961604.1 cytoplasmic polyadenylation element-binding protein 1 isoform X13

Conserved Domains (4) summary

pfam16366
Location:289 → 344

CEBP_ZZ; Cytoplasmic polyadenylation element-binding protein ZZ domain

pfam16368
Location:1 → 92

CEBP1_N; Cytoplasmic polyadenylation element-binding protein 1 N-terminus

cd12723
Location:94 → 201

RRM1_CPEB1; RNA recognition motif 1 (RRM1) found in cytoplasmic polyadenylation element-binding protein 1 (CPEB-1) and similar proteins

cd12725
Location:212 → 295

RRM2_CPEB1; RNA recognition motif 2 (RRM2) found in cytoplasmic polyadenylation element-binding protein 1 (CPEB-1) and similar proteins