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    Slc10a6 solute carrier family 10 member 6 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 289459, updated on 13-Apr-2024

    Summary

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    Official Symbol
    Slc10a6provided by RGD
    Official Full Name
    solute carrier family 10 member 6provided by RGD
    Primary source
    RGD:727800
    See related
    Ensembl:ENSRNOG00000002057 AllianceGenome:RGD:727800
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Soat
    Summary
    Enables sodium-dependent organic anion transmembrane transporter activity. Involved in sodium-dependent organic anion transport. Predicted to be located in plasma membrane. Predicted to be integral component of membrane. Orthologous to human SLC10A6 (solute carrier family 10 member 6). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Uterus (RPKM 36.6), Spleen (RPKM 32.2) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Slc10a6 in Genome Data Viewer
    Location:
    14p22
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 14 NC_086032.1 (6385348..6407532)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 14 NC_051349.1 (6080716..6102902)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 14 NC_005113.4 (7618022..7682377)

    Chromosome 14 - NC_086032.1Genomic Context describing neighboring genes Neighboring gene similar to human chromosome 4 open reading frame 36 Neighboring gene uncharacterized LOC102546534 Neighboring gene protein tyrosine phosphatase, non-receptor type 13 Neighboring gene uncharacterized LOC134481819 Neighboring gene uncharacterized LOC134481699

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Identification of a sodium-dependent organic anion transporter from rat adrenal gland. Geyer J, et al. Biochem Biophys Res Commun, 2004 Apr 2. PMID 15020217
    2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Cloning and analysis of transport function of Soat.
      Title: Identification of a sodium-dependent organic anion transporter from rat adrenal gland.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables bile acid:sodium symporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables sodium-dependent organic anion transmembrane transporter activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in bile acid and bile salt transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in sodium ion transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in sodium-dependent organic anion transport IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    sodium-dependent organic anion transporter
    Names
    solute carrier family 10 (sodium/bile acid cotransporter family), member 6
    solute carrier family 10 (sodium/bile acid cotransporter), member 6

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_198049.2 → NP_932166.1  sodium-dependent organic anion transporter

      See identical proteins and their annotated locations for NP_932166.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000014
      UniProtKB/Swiss-Prot
      Q70EX6
      Related
      ENSRNOP00000072386.1, ENSRNOT00000088508.2
      Conserved Domains (1) summary
      TIGR00841
      Location:34 → 312
      bass; bile acid transporter

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086032.1 Reference GRCr8

      Range
      6385348..6407532
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039091662.2 → XP_038947590.1  sodium-dependent organic anion transporter isoform X1

      Conserved Domains (1) summary
      cl19217
      Location:34 → 196
      SBF; Sodium Bile acid symporter family
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q70EX6.1 GenPept UniProtKB/Swiss-Prot:Q70EX6

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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