CYP19A1 cytochrome P450 family 19 subfamily A member 1 [Bos taurus (cattle)] - Gene

Summary

Official Symbol: CYP19A1provided by VGNC
Official Full Name: cytochrome P450 family 19 subfamily A member 1provided by VGNC
Primary source: VGNC:VGNC:110231
See related: BGD:BT17636; Ensembl:ENSBTAG00000014890
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Bos taurus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
Also known as: CYP19; CYP19P1
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 10

Exon count:: 10

Annotation release	Status	Assembly	Chr	Location
RS_2023_09	current	ARS-UCD2.0 (GCF_002263795.3)	10	NC_037337.1 (59102240..59156621)

Chromosome 10 - NC_037337.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:: NC_037337.1 Chromosome 10 Reference ARS-UCD2.0 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

miR-326 down-regulate CYP19A1 expression and estradiol-17b production in buffalo granulosa cells through CREB and C/EBP-beta.
Title: miR-326 down-regulate CYP19A1 expression and estradiol-17b production in buffalo granulosa cells through CREB and C/EBP-β.
These data suggest that posttranscriptional regulation is an important component of the control of CYP19A1 expression and involves protein binding to a specific sequence in the 3'UTR.
Title: A putative protein-RNA complex regulates posttranscriptional processing of cytochrome P450 aromatase (CYP19A1) in bovine granulosa cells.
This study examined the calibration of follicular development in chickens and cattle according to gene expression patterns. Unlike mammals, ESR2 was implicated as one of transcription factors regulating CYP19A1 expression in chicken follicles.
Title: A transcriptomic comparison of theca and granulosa cells in chicken and cattle follicles reveals ESR2 as a potential regulator of CYP19A1 expression in the theca cells of chicken follicles.
The CYP19A1 gene contributes to genetic variation of in vitro embryo production traits in cattle. The complexity of the physiological phenomena related to estrogen pathways and their influence on reproduction in cattle allow indication of the mutations evaluated here as possible genetic markers for embryo production traits, which should be validated in the next steps of marker-assisted selection.
Title: Variants in the CYP19A1 gene can affect in vitro embryo production traits in cattle.
in granulosa cells of dominant follicles the concentration of CYP19P1 mRNA was very low compared to CYP19A1 mRNA. CONCLUSIONS: CYP19P1 and CYP19A1 transcripts might interfere in placental cotyledons
Title: Evaluation of coding-independent functions of the transcribed bovine aromatase pseudogene CYP19P1.
These data suggest that a major reason why CYP19A1 is not expressed in luteinized cells (and the corpus luteum) of ruminants may be the stimulatory effect of FOXL2, which does not appear to be the case in the human and rat.
Title: Factors regulating the bovine, caprine, rat and human ovarian aromatase promoters in a bovine granulosa cell model.
This study evaluated the relationships among aromatase, IGF-1, IGF2R, and FSH levels expressed in ovarian follicles of cattle selected for twin pregnancies.
Title: Increased abundance of aromatase and follicle stimulating hormone receptor mRNA and decreased insulin-like growth factor-2 receptor mRNA in small ovarian follicles of cattle selected for twin births.
Data indicated de novo DNA methylation fter the luteinizing hormone-induced down-regulation of CYP19A1 expression, suggesting that DNA methylation might play a role for permanent silencing of previously down-regulated genes.
Title: Bovine large luteal cells show increasing de novo DNA methylation of the main ovarian CYP19A1 promoter P2.
P450(AROM) is localized in the cytoplasm and only seldom present in the fine extensions of the cells in frontal cortex.
Title: Expression and localization of aromatase P450AROM, estrogen receptor-α, and estrogen receptor-β in the developing fetal bovine frontal cortex.
Granulosa and theca of well-characterized large bovine follicles were isolated before and after the LH surge. CYP19A1, HSD3B1, and CYP17A1 transcripts were quantified by real-time PCR (qPCR) and the chromatin condensation was determined.
Title: The pre-ovulatory luteinizing hormone surge is followed by down-regulation of CYP19A1, HSD3B1, and CYP17A1 and chromatin condensation of the corresponding promoters in bovine follicles.

Submit: New GeneRIF Correction See all GeneRIFs (21)

General gene information

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Markers

CYP19 (e-PCR), detects polymorphism
- UniSTS:253925

CYP19A1_(3) (e-PCR)
- UniSTS:278266

CYP19A1_(5) (e-PCR)
- UniSTS:278267

Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables heme binding	IEA Inferred from Electronic Annotation more info	PubMed
enables iron ion binding	IEA Inferred from Electronic Annotation more info	PubMed
enables monooxygenase activity	IEA Inferred from Electronic Annotation more info	PubMed
enables oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

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Preferred Names: aromatase

Names: CYPXIX; P-450AROM; aromatase cytochrome P450; cytochrome P-450AROM; cytochrome P450 19A1; cytochrome P450, family 19, subfamily A, polypeptide 1; estrogen synthase; estrogen synthetase

NP_776730.1

EC 1.14.14.14

XP_059746204.1

EC 1.14.14.14

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.