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    AGTR1 angiotensin II receptor type 1 [ Bos taurus (cattle) ]

    Gene ID: 281607, updated on 5-Mar-2024

    Summary

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    Official Symbol
    AGTR1provided by VGNC
    Official Full Name
    angiotensin II receptor type 1provided by VGNC
    Primary source
    VGNC:VGNC:25745
    See related
    BGD:BT11709; Ensembl:ENSBTAG00000045633
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Bos taurus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
    Orthologs
    human mouse all
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    Genomic context

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    Location:
    chromosome: 1
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    RS_2023_09 current ARS-UCD2.0 (GCF_002263795.3) 1 NC_037328.1 (119465670..119521250, complement)

    Chromosome 1 - NC_037328.1Genomic Context describing neighboring genes Neighboring gene carboxypeptidase A3 Neighboring gene carboxypeptidase B1 Neighboring gene pre-mRNA-splicing factor SPF27-like Neighboring gene uncharacterized LOC132345847

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_037328.1 Chromosome 1 Reference ARS-UCD2.0 Primary Assembly

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Cloning and expression of a complementary DNA encoding a bovine adrenal angiotensin II type-1 receptor. Sasaki K, et al. Nature, 1991 May 16. PMID 2041569
    2. TREK-1 K+ channels couple angiotensin II receptors to membrane depolarization and aldosterone secretion in bovine adrenal glomerulosa cells. Enyeart JA, et al. Am J Physiol Endocrinol Metab, 2004 Dec. PMID 15315905
    3. Angiotensin II inhibits native bTREK-1 K+ channels through a PLC-, kinase C-, and PIP2-independent pathway requiring ATP hydrolysis. Liu H, et al. Am J Physiol Cell Physiol, 2007 Aug. PMID 17494631
    4. A whole-genome assembly of the domestic cow, Bos taurus. Zimin AV, et al. Genome Biol, 2009. PMID 19393038, Free PMC Article

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Angiotensin II (ANGII) inhibits adrenocortical cell KCNK2 in an ATP dependent, PLC/PKC independent manner.
      Title: Angiotensin II inhibits native bTREK-1 K+ channels through a PLC-, kinase C-, and PIP2-independent pathway requiring ATP hydrolysis.
    2. These results identify bTREK-1 K(+) channels as a pivotal control point where ANG II receptor activation is transduced to depolarization-dependent Ca(2+) entry and aldosterone secretion.
      Title: TREK-1 K+ channels couple angiotensin II receptors to membrane depolarization and aldosterone secretion in bovine adrenal glomerulosa cells.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables angiotensin type II receptor activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in G protein-coupled receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in immune response IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in regulation of vasoconstriction IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    type-1 angiotensin II receptor
    Names
    AT1
    AT1 receptor
    angiotensin II receptor 1
    angiotensin II type-1 receptor
    angiotensin receptor 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_174233.2 → NP_776658.1  type-1 angiotensin II receptor

      See identical proteins and their annotated locations for NP_776658.1

      Status: PROVISIONAL

      Source sequence(s)
      X62294
      UniProtKB/Swiss-Prot
      P25104
      UniProtKB/TrEMBL
      Q0VCD5
      Related
      ENSBTAP00000093439.1, ENSBTAT00000110916.1
      Conserved Domains (1) summary
      cd15192
      Location:29 → 313
      7tmA_AT1R; type 1 angiotensin II receptor, member of the class A family of seven-transmembrane G protein-coupled receptors

    RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2023_09

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ARS-UCD2.0 Primary Assembly

    Genomic

    1. NC_037328.1 Reference ARS-UCD2.0 Primary Assembly

      Range
      119465670..119521250 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_024990377.2 → XP_024846145.1  type-1 angiotensin II receptor isoform X1

      UniProtKB/Swiss-Prot
      P25104
      UniProtKB/TrEMBL
      Q0VCD5
      Related
      ENSBTAP00000077513.1, ENSBTAT00000114712.1
      Conserved Domains (1) summary
      cd15192
      Location:29 → 313
      7tmA_AT1R; type 1 angiotensin II receptor, member of the class A family of seven-transmembrane G protein-coupled receptors
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P25104.1 GenPept UniProtKB/Swiss-Prot:P25104

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.