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    Lypla2 lysophospholipase 2 [ Mus musculus (house mouse) ]

    Gene ID: 26394, updated on 5-Mar-2024

    Summary

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    Official Symbol
    Lypla2provided by MGI
    Official Full Name
    lysophospholipase 2provided by MGI
    Primary source
    MGI:MGI:1347000
    See related
    Ensembl:ENSMUSG00000028670 AllianceGenome:MGI:1347000
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    LysoII
    Summary
    Enables palmitoyl-(protein) hydrolase activity. Involved in prostaglandin catabolic process and protein depalmitoylation. Located in Golgi stack. Is expressed in several structures, including alimentary system; eye; integumental system; nervous system; and urinary system. Orthologous to human LYPLA2 (lysophospholipase 2). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in colon adult (RPKM 103.7), duodenum adult (RPKM 82.5) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Lypla2 in Genome Data Viewer
    Location:
    4 D3; 4 68.33 cM
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (135695541..135700954, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (135968224..135972612, complement)

    Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene 3-hydroxy-3-methylglutaryl-Coenzyme A lyase Neighboring gene STARR-positive B cell enhancer ABC_E4686 Neighboring gene STARR-positive B cell enhancer ABC_E3529 Neighboring gene galactose-4-epimerase, UDP Neighboring gene CapStarr-seq enhancer MGSCv37_chr4:135528566-135528675 Neighboring gene PITH (C-terminal proteasome-interacting domain of thioredoxin-like) domain containing 1 Neighboring gene predicted gene 13007

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Palmitoylation couples insulin hypersecretion with β cell failure in diabetes. Dong G, et al. Cell Metab, 2023 Feb 7. PMID 36634673, Free PMC Article
    2. Temporal Profiling Establishes a Dynamic S-Palmitoylation Cycle. Won SJ, et al. ACS Chem Biol, 2018 Jun 15. PMID 29733200, Free PMC Article
    3. Identification of the major prostaglandin glycerol ester hydrolase in human cancer cells. Manna JD, et al. J Biol Chem, 2014 Dec 5. PMID 25301951, Free PMC Article
    4. Prediction of human cDNA from its homologous mouse full-length cDNA and human shotgun database. Fukunishi Y, et al. FEBS Lett, 1999 Dec 31. PMID 10618491
    5. Sequence, expression in Escherichia coli, and characterization of lysophospholipase II. Toyoda T, et al. Biochim Biophys Acta, 1999 Feb 25. PMID 10064901

    See all (29) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Data indicate that thioesterases APT1/APT2 depalmitoylate nicotinamide mononucleotide adenylyltransferase 2 (NMNAT2) and zDHHC17 is the strongest candidate palmitoyltransferase for NMNAT2.
      Title: Identification of palmitoyltransferase and thioesterase enzymes that control the subcellular localization of axon survival factor nicotinamide mononucleotide adenylyltransferase 2 (NMNAT2).
    2. Dynamic palmitoylation links cytosol-membrane shuttling of acyl-protein thioesterase-1 and acyl-protein thioesterase-2 with that of proto-oncogene H-ras product and growth-associated protein-43
      Title: Dynamic palmitoylation links cytosol-membrane shuttling of acyl-protein thioesterase-1 and acyl-protein thioesterase-2 with that of proto-oncogene H-ras product and growth-associated protein-43.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (3)  1 citation
    • Endonuclease-mediated (2) 

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables carboxylic ester hydrolase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables lysophospholipase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables palmitoyl-(protein) hydrolase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables palmitoyl-(protein) hydrolase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables palmitoyl-(protein) hydrolase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in acylglycerol catabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within fatty acid metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within lipid metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in prostaglandin catabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in prostaglandin catabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein depalmitoylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein depalmitoylation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in protein depalmitoylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in Golgi stack IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    acyl-protein thioesterase 2
    Names
    APT-2
    LPL-II
    lysoPLA II
    lysophospholipase II
    mLyso II
    palmitoyl-protein hydrolase
    NP_001405973.1
    NP_001405974.1
    NP_001405975.1
    NP_036072.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001419044.1 → NP_001405973.1  acyl-protein thioesterase 2

      Status: VALIDATED

      Source sequence(s)
      AL672076
      UniProtKB/Swiss-Prot
      Q3TJD6, Q9WTL7

    2. NM_001419045.1 → NP_001405974.1  acyl-protein thioesterase 2

      Status: VALIDATED

      Source sequence(s)
      AL672076
      UniProtKB/Swiss-Prot
      Q3TJD6, Q9WTL7
      Related
      ENSMUSP00000101478.2, ENSMUST00000105852.8

    3. NM_001419046.1 → NP_001405975.1  acyl-protein thioesterase 2

      Status: VALIDATED

      Source sequence(s)
      AL672076
      UniProtKB/Swiss-Prot
      Q3TJD6, Q9WTL7

    4. NM_011942.2 → NP_036072.1  acyl-protein thioesterase 2

      See identical proteins and their annotated locations for NP_036072.1

      Status: VALIDATED

      Source sequence(s)
      AL672076
      Consensus CDS
      CCDS18797.1
      UniProtKB/Swiss-Prot
      Q3TJD6, Q9WTL7
      Related
      ENSMUSP00000064204.5, ENSMUST00000067567.5
      Conserved Domains (1) summary
      pfam02230
      Location:14 → 228
      Abhydrolase_2; Phospholipase/Carboxylesterase

    RNA

    1. NR_185005.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AL672076

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000070.7 Reference GRCm39 C57BL/6J

      Range
      135695541..135700954 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9WTL7.1 GenPept UniProtKB/Swiss-Prot:Q9WTL7

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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