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    TUBB8B tubulin beta 8B [ Homo sapiens (human) ]

    Gene ID: 260334, updated on 5-Mar-2024

    Summary

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    Official Symbol
    TUBB8Bprovided by HGNC
    Official Full Name
    tubulin beta 8Bprovided by HGNC
    Primary source
    HGNC:HGNC:24983
    See related
    Ensembl:ENSG00000173213 AllianceGenome:HGNC:24983
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    TUBB8P12
    Summary
    Predicted to enable GTP binding activity. Predicted to be a structural constituent of cytoskeleton. Predicted to be involved in microtubule cytoskeleton organization and mitotic cell cycle. Located in extracellular exosome. [provided by Alliance of Genome Resources, Apr 2022]
    Orthologs
    all
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    Genomic context

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    Location:
    18p11.32
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 18 NC_000018.10 (47212..73539, complement)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 18 NC_060942.1 (201006..227325, complement)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 18 NC_000018.9 (47221..73539, complement)

    Chromosome 18 - NC_000018.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC124904234 Neighboring gene long intergenic non-protein coding RNA 2564 Neighboring gene uncharacterized LOC105371950 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr18:78692-79192 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr18:79193-79693 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr18:81490-82403 Neighboring gene IL9R pseudogene 4 Neighboring gene Sharpr-MPRA regulatory region 10972 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr18:106915-107598 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr18:107891-108680 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr18:108681-109468 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr18:109469-110257 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr18:110258-111045 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9235 Neighboring gene Rho associated coiled-coil containing protein kinase 1 pseudogene 1 Neighboring gene microRNA 8078

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. A cascade of complex subtelomeric duplications during the evolution of the hominoid and Old World monkey genomes. van Geel M, et al. Am J Hum Genet, 2002 Jan. PMID 11731935, Free PMC Article
    2. CCT3 acts upstream of YAP and TFCP2 as a potential target and tumour biomarker in liver cancer. Liu Y, et al. Cell Death Dis, 2019 Sep 9. PMID 31501420, Free PMC Article
    3. The HIV-1 Tat protein recruits a ubiquitin ligase to reorganize the 7SK snRNP for transcriptional activation. Faust TB, et al. Elife, 2018 May 30. PMID 29845934, Free PMC Article
    4. BAP1 regulation of the key adaptor protein NCoR1 is critical for γ-globin gene repression. Yu L, et al. Genes Dev, 2018 Dec 1. PMID 30463901, Free PMC Article
    5. In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine. Principe S, et al. Proteomics, 2013 May. PMID 23533145, Free PMC Article

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Phenotypes

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    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables GTP binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables GTPase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables structural constituent of cytoskeleton IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in microtubule cytoskeleton organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in mitotic cell cycle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in extracellular exosome HDA PubMed 
    located_in intercellular bridge IDA
    Inferred from Direct Assay
    more info
    		  
    is_active_in microtubule IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in microtubule cytoskeleton IDA
    Inferred from Direct Assay
    more info
    		  
    located_in mitotic spindle IDA
    Inferred from Direct Assay
    more info
    		  

    General protein information

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    Preferred Names
    tubulin beta 8B
    Names
    HSA18p11 beta-tubulin 4Q pseudogene
    Tubulin beta-8 chain-like protein LOC260334
    tubulin beta 8 pseudogene 12

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001358689.2 → NP_001345618.1  tubulin beta 8B isoform 1

      Status: VALIDATED

      Source sequence(s)
      AP001005
      Consensus CDS
      CCDS86657.1
      UniProtKB/Swiss-Prot
      A6NNZ2
      UniProtKB/TrEMBL
      A0A183YE00
      Related
      ENSP00000496713.1, ENST00000308911.9
      Conserved Domains (1) summary
      PLN00220
      Location:1 → 427
      PLN00220; tubulin beta chain; Provisional

    2. NM_001389609.1 → NP_001376538.1  tubulin beta 8B isoform 2

      Status: VALIDATED

      Source sequence(s)
      AP001005
      UniProtKB/TrEMBL
      A0A075B736
      Conserved Domains (1) summary
      PLN00220
      Location:1 → 355
      PLN00220; tubulin beta chain; Provisional

    3. NM_001389610.1 → NP_001376539.1  tubulin beta 8B isoform 3

      Status: VALIDATED

      Source sequence(s)
      AP001005
      Conserved Domains (1) summary
      cd02187
      Location:112 → 375
      beta_tubulin; The beta-tubulin family

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000018.10 Reference GRCh38.p14 Primary Assembly

      Range
      47212..73539 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_024451147.2 → XP_024306915.1  tubulin beta 8B isoform X3

      UniProtKB/TrEMBL
      Q9UGA2
      Conserved Domains (1) summary
      PTZ00010
      Location:1 → 311
      PTZ00010; tubulin beta chain; Provisional

    2. XM_024451143.2 → XP_024306911.1  tubulin beta 8B isoform X1

      Related
      ENST00000706408.1
      Conserved Domains (1) summary
      cd02187
      Location:112 → 375
      beta_tubulin; The beta-tubulin family

    3. XM_024451144.2 → XP_024306912.1  tubulin beta 8B isoform X1

      Conserved Domains (1) summary
      cd02187
      Location:112 → 375
      beta_tubulin; The beta-tubulin family

    4. XM_024451146.2 → XP_024306914.1  tubulin beta 8B isoform X2

      UniProtKB/TrEMBL
      Q5SQY0
      Conserved Domains (1) summary
      cd02187
      Location:13 → 346
      beta_tubulin; The beta-tubulin family

    5. XM_024451148.2 → XP_024306916.1  tubulin beta 8B isoform X4

      UniProtKB/TrEMBL
      Q96B85
      Conserved Domains (1) summary
      cd02187
      Location:10 → 273
      beta_tubulin; The beta-tubulin family

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060942.1 Alternate T2T-CHM13v2.0

      Range
      201006..227325 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NG_002339.3: Suppressed sequence

      Description
      NG_002339.3: This RefSeq was removed because it is currently thought that this locus produces a protein.
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A6NNZ2.1 GenPept UniProtKB/Swiss-Prot:A6NNZ2

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Molecular Biology Databases
    Research Materials