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    rna1 Ran GAP Rna1 [ Schizosaccharomyces pombe (fission yeast) ]

    Gene ID: 2541863, updated on 15-Mar-2024

    Summary

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    Gene symbol
    rna1
    Gene description
    Ran GAP Rna1
    Primary source
    PomBase:SPAC22E12.07
    Locus tag
    SPAC22E12.07
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Schizosaccharomyces pombe (strain: 972h-)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina; Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae; Schizosaccharomyces
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    Genomic context

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    Location:
    chromosome: I
    Exon count:
    1
    Sequence:
    Chromosome: I; NC_003424.3 (5030439..5033261)

    Chromosome I - NC_003424.3Genomic Context describing neighboring genes Neighboring gene superoxide dismutase Cu chaperone Ccs1 Neighboring gene putative Rer1 family protein Neighboring gene alpha-1,2-galactosyltransferase Gmh3 Neighboring gene miscRNA Neighboring gene RNA polymerase I upstream activation factor complex subunit Rrn10 Neighboring gene kexin Neighboring gene cytochrome oxidase cofactor Cox15/type I ferredoxin Etp1 protein etp1

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003424.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A functional homologue of the RNA1 gene product in Schizosaccharomyces pombe: purification, biochemical characterization, and identification of a leucine-rich repeat motif. Melchior F, et al. Mol Biol Cell, 1993 Jun. PMID 8374168, Free PMC Article
    2. RanGAP mediates GTP hydrolysis without an arginine finger. Seewald MJ, et al. Nature, 2002 Feb 7. PMID 11832950
    3. The crystal structure of rna1p: a new fold for a GTPase-activating protein. Hillig RC, et al. Mol Cell, 1999 Jun. PMID 10394366
    4. Structure of a Ran-binding domain complexed with Ran bound to a GTP analogue: implications for nuclear transport. Vetter IR, et al. Nature, 1999 Mar 4. PMID 10078529
    5. The acidic C-terminal domain of rna1p is required for the binding of Ran.GTP and for RanGAP activity. Haberland J, et al. J Biol Chem, 1997 Sep 26. PMID 9305944

    See all (18) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. SpRna1 has roles in centromeric silencing and chromosome segregation
      Title: Schizosaccharomyces pombe RanGAP homolog, SpRna1, is required for centromeric silencing and chromosome segregation.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by PomBase

    Function Evidence Code Pubs
    enables GTPase activator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    contributes_to GTPase activator activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables GTPase activator activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables small GTPase binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in activation of GTPase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in nucleocytoplasmic transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein export from nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in cytosol HDA PubMed 
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in nuclear periphery IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in perinuclear region of cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    Ran GAP Rna1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003424.3 Reference assembly

      Range
      5030439..5033261
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001020262.2 → NP_594833.1  Ran GAP Rna1 [Schizosaccharomyces pombe]

      See identical proteins and their annotated locations for NP_594833.1

      Status: PROVISIONAL

      UniProtKB/Swiss-Prot
      P41391
      Conserved Domains (3) summary
      COG5238
      Location:1 → 386
      RNA1; Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Signal transduction mechanisms, RNA processing and modification]
      cd00116
      Location:3 → 332
      LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
      sd00033
      Location:96 → 120
      LRR_RI; leucine-rich repeat [structural motif]
    Nucleotide Protein
    Heading Accession and Version

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