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    Cd247 Cd247 molecule [ Rattus norvegicus (Norway rat) ]

    Gene ID: 25300, updated on 13-Apr-2024

    Summary

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    Official Symbol
    Cd247provided by RGD
    Official Full Name
    Cd247 moleculeprovided by RGD
    Primary source
    RGD:2305
    See related
    Ensembl:ENSRNOG00000003298 AllianceGenome:RGD:2305
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Cd3z; TCRzeta
    Summary
    Predicted to enable identical protein binding activity and protein tyrosine kinase binding activity. Involved in cell surface receptor signaling pathway. Part of T cell receptor complex. Human ortholog(s) of this gene implicated in immunodeficiency 25. Orthologous to human CD247 (CD247 molecule). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Thymus (RPKM 929.3), Spleen (RPKM 119.9) and 1 other tissue See more
    Orthologs
    human mouse all
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    Genomic context

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    Location:
    13q23
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 13 NC_086031.1 (80576264..80651422)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 13 NC_051348.1 (78043302..78118437)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 13 NC_005112.4 (83996045..84071408)

    Chromosome 13 - NC_086031.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC120096305 Neighboring gene cellular repressor of E1A-stimulated genes 1 Neighboring gene POU class 2 homeobox 1 Neighboring gene uncharacterized LOC134481526

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. CD247 modulates blood pressure by altering T-lymphocyte infiltration in the kidney. Rudemiller N, et al. Hypertension, 2014 Mar. PMID 24343121, Free PMC Article
    2. Ectopic expression of the immune adaptor protein CD3zeta in neural stem/progenitor cells disrupts cell-fate specification. Angibaud J, et al. J Mol Neurosci, 2012 Feb. PMID 21809042
    3. The signaling adaptor protein CD3zeta is a negative regulator of dendrite development in young neurons. Baudouin SJ, et al. Mol Biol Cell, 2008 Jun. PMID 18367546, Free PMC Article
    4. Effect of TNF-alpha on CD3-zeta and MHC-I in postnatal rat hippocampus. Sourial-Bassillious N, et al. Pediatr Res, 2006 Oct. PMID 16940250
    5. Changes in Expressions of Major Histocompatibility Complex Class I, Paired-Immunoglobulin-Like Receptor B, and Cluster of Differentiation 3ζ in Motor Cortical Representations of the Brachial Plexus After Avulsion in Rats. Zhang J, et al. World Neurosurg, 2017 Oct. PMID 28669876

    See all (22) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. In the original motor cortical representations of the brachial plexus, mRNA and protein expression levels of MHCI, PirB, and CD3zeta were down-regulated 7 days post brachial plexus injury compared with control. Interestingly, mRNA and protein expression levels of these factors were up-regulated at 3 months compared with 7 days, excepting PirB protein, whose expression was not increasing.
      Title: Changes in Expressions of Major Histocompatibility Complex Class I, Paired-Immunoglobulin-Like Receptor B, and Cluster of Differentiation 3ζ in Motor Cortical Representations of the Brachial Plexus After Avulsion in Rats.
    2. functional T cells are required for the full development of Dahl salt-sensitive hypertension and indicate that the association between CD247 and hypertension in humans may be related to altered immune cell function.
      Title: CD247 modulates blood pressure by altering T-lymphocyte infiltration in the kidney.
    3. ectopic CD3zeta expression in neural precursor stem cells impaired their normal cell-fate specification. Variations of CD3zeta expression in the developing CNS might result in neurodevelopmental anomalies.
      Title: Ectopic expression of the immune adaptor protein CD3zeta in neural stem/progenitor cells disrupts cell-fate specification.
    4. The transmembrane adaptor signaling protein CD3zeta, first described in the immune system, has a previously uncharacterized role in regulating neuronal development.
      Title: The signaling adaptor protein CD3zeta is a negative regulator of dendrite development in young neurons.
    5. Tere is a robust postnatal up-regulation of CD3-zeta in rat hippocampus in early postnatal period.
      Title: Effect of TNF-alpha on CD3-zeta and MHC-I in postnatal rat hippocampus.
    6. experimental, computational and evolutionary approaches predicts the presence of a tetrameric form for CD3-zeta
      Title: Convergence of experimental, computational and evolutionary approaches predicts the presence of a tetrameric form for CD3-zeta.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein heterodimerization activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein homodimerization activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein tyrosine kinase binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables transmembrane signaling receptor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in Fc-gamma receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in T cell receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within T cell receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in cell surface receptor signaling pathway IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within positive regulation of protein localization to cell surface ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein complex oligomerization ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein-containing complex assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    part_of Fc-gamma receptor III complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in Golgi apparatus ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of T cell receptor complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of T cell receptor complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of alpha-beta T cell receptor complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of alpha-beta T cell receptor complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    T-cell surface glycoprotein CD3 zeta chain
    Names
    CD247 antigen
    CD3 antigen, zeta polypeptide
    T-cell receptor CD3, subunit zeta

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001205304.1 → NP_001192233.1  T-cell surface glycoprotein CD3 zeta chain isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an in-frame coding exon, as compared to variant 1. The resulting isoform (2) lacks an internal segment, compared to isoform 1.
      Source sequence(s)
      BC097933, CO562119, JAXUCZ010000013
      UniProtKB/TrEMBL
      M0R576, Q4V7G0
      Conserved Domains (2) summary
      pfam02189
      Location:112 → 131
      ITAM; Immunoreceptor tyrosine-based activation motif
      pfam11628
      Location:28 → 58
      TCR_zetazeta; T-cell surface glycoprotein CD3 zeta chain

    2. NM_170789.2 → NP_740770.2  T-cell surface glycoprotein CD3 zeta chain isoform 1

      See identical proteins and their annotated locations for NP_740770.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longer isoform (1).
      Source sequence(s)
      BC097933, JAXUCZ010000013
      UniProtKB/TrEMBL
      A6IDI4, F7FGL4, Q4V7G0
      Related
      ENSRNOP00000004403.5, ENSRNOT00000004403.9
      Conserved Domains (3) summary
      smart00077
      Location:69 → 89
      ITAM; Immunoreceptor tyrosine-based activation motif
      pfam02189
      Location:139 → 158
      ITAM; Immunoreceptor tyrosine-based activation motif
      pfam11628
      Location:28 → 58
      TCR_zetazeta; T-cell surface glycoprotein CD3 zeta chain

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086031.1 Reference GRCr8

      Range
      80576264..80651422
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006250147.4 → XP_006250209.1  T-cell surface glycoprotein CD3 zeta chain isoform X1

      UniProtKB/TrEMBL
      A6IDI4
      Conserved Domains (3) summary
      smart00077
      Location:69 → 89
      ITAM; Immunoreceptor tyrosine-based activation motif
      pfam02189
      Location:138 → 157
      ITAM; Immunoreceptor tyrosine-based activation motif
      pfam11628
      Location:28 → 58
      TCR_zetazeta; T-cell surface glycoprotein CD3 zeta chain
    Nucleotide Protein Strain
    Heading Accession and Version

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