Lyz2 lysozyme 2 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Lyz2provided by RGD
Official Full Name: lysozyme 2provided by RGD
Primary source: RGD:3026
See related: Ensembl:ENSRNOG00000005825 AllianceGenome:RGD:3026
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Lyz; Lysz; Lyz1
Summary: Enables lysozyme activity. Involved in defense response to Gram-negative bacterium and defense response to Gram-positive bacterium. Located in several cellular components, including Golgi cis cisterna; cytoplasmic vesicle; and rough endoplasmic reticulum lumen. Human ortholog(s) of this gene implicated in familial visceral amyloidosis. Orthologous to human LYZ (lysozyme). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Lung (RPKM 51113.8) and Spleen (RPKM 4301.1) See more
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Genomic context

Location:: 7q22

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	7	NC_086025.1 (54792715..54798060, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	7	NC_051342.1 (52906810..52912154, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	7	NC_005106.4 (60335968..60341264, complement)

Chromosome 7 - NC_086025.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Submit: New GeneRIF Correction

General gene information

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Markers

RH127643 (e-PCR)
- UniSTS:210953

D7Wox39 (e-PCR)
- UniSTS:239385

D7MGH22 (e-PCR)
- UniSTS:120500

RH127838 (e-PCR)
- UniSTS:211148

RH94553 (e-PCR)
- UniSTS:119801

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables hydrolase activity, acting on glycosyl bonds	IMP Inferred from Mutant Phenotype more info	PubMed
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables lysozyme activity	IBA Inferred from Biological aspect of Ancestor more info
enables lysozyme activity	IDA Inferred from Direct Assay more info	PubMed
enables lysozyme activity	IEA Inferred from Electronic Annotation more info
enables lysozyme activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables lysozyme activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in defense response to Gram-negative bacterium	IBA Inferred from Biological aspect of Ancestor more info
involved_in defense response to Gram-negative bacterium	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in defense response to Gram-negative bacterium	ISO Inferred from Sequence Orthology more info
involved_in defense response to Gram-positive bacterium	IBA Inferred from Biological aspect of Ancestor more info
involved_in defense response to Gram-positive bacterium	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in defense response to Gram-positive bacterium	ISO Inferred from Sequence Orthology more info
involved_in defense response to bacterium	ISO Inferred from Sequence Orthology more info
involved_in killing of cells of another organism	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in Golgi cis cisterna	IDA Inferred from Direct Assay more info	PubMed
located_in Golgi stack	IDA Inferred from Direct Assay more info	PubMed
located_in endoplasmic reticulum lumen	IDA Inferred from Direct Assay more info	PubMed
located_in extracellular space	ISO Inferred from Sequence Orthology more info
located_in microvillus	IDA Inferred from Direct Assay more info	PubMed
located_in rough endoplasmic reticulum lumen	IDA Inferred from Direct Assay more info	PubMed
located_in secretory granule	IDA Inferred from Direct Assay more info	PubMed
located_in trans-Golgi network transport vesicle	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: lysozyme C-1

Names: 1,4-beta-N-acetylmuramidase C

NP_036903.2

EC 3.2.1.17

XP_038934368.1

EC 3.2.1.17

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_012771.3 → NP_036903.2 lysozyme C-1 precursor

See identical proteins and their annotated locations for NP_036903.2

Status: PROVISIONAL

Source sequence(s)

BC058490

UniProtKB/Swiss-Prot

P00697

UniProtKB/TrEMBL

A0A077S1I6, Q6PDV1

Conserved Domains (1) summary

smart00263
Location:19 → 147

LYZ1; Alpha-lactalbumin / lysozyme C

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086025.1 Reference GRCr8

Range

54792715..54798060 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039078440.2 → XP_038934368.1 lysozyme C-1 isoform X1

UniProtKB/TrEMBL

F1M8E9

Related

ENSRNOP00000007747.5

Conserved Domains (1) summary

smart00263
Location:19 → 191

LYZ1; Alpha-lactalbumin / lysozyme C