Pgm5 phosphoglucomutase 5 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Pgm5provided by MGI
Official Full Name: phosphoglucomutase 5provided by MGI
Primary source: MGI:MGI:1925668
See related: Ensembl:ENSMUSG00000041731 AllianceGenome:MGI:1925668
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: aciculin; 4833423B07; D830025G17; 9530034F03Rik
Summary: Predicted to enable magnesium ion binding activity. Predicted to be involved in carbohydrate metabolic process; myofibril assembly; and striated muscle tissue development. Predicted to act upstream of or within cell adhesion and glucose metabolic process. Located in Z disc; cell-substrate junction; and sarcolemma. Part of dystrophin-associated glycoprotein complex. Is expressed in tail unsegmented mesenchyme. Orthologous to human PGM5 (phosphoglucomutase 5). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in bladder adult (RPKM 105.7), colon adult (RPKM 13.9) and 6 other tissues See more
Orthologs: human all
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Genomic context

Location:: 19 B; 19 19.78 cM

Exon count:: 11

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	19	NC_000085.7 (24655625..24839206, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	19	NC_000085.6 (24678261..24861842, complement)

Chromosome 19 - NC_000085.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Aciculin interacts with filamin C and Xin and is essential for myofibril assembly.
Title: Aciculin interacts with filamin C and Xin and is essential for myofibril assembly, remodeling and maintenance.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (4)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

NoName (e-PCR)
- UniSTS:487707

NoName (e-PCR)
- UniSTS:237913

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
NOT enables intramolecular phosphotransferase activity	IDA Inferred from Direct Assay more info	PubMed
enables magnesium ion binding	IEA Inferred from Electronic Annotation more info
NOT enables phosphoglucomutase activity	IBA Inferred from Biological aspect of Ancestor more info
NOT enables phosphoglucomutase activity	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in carbohydrate metabolic process	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within cell adhesion	IEA Inferred from Electronic Annotation more info
involved_in myofibril assembly	IBA Inferred from Biological aspect of Ancestor more info
involved_in organic substance metabolic process	IEA Inferred from Electronic Annotation more info
involved_in striated muscle tissue development	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in Z disc	IDA Inferred from Direct Assay more info	PubMed
is_active_in adherens junction	IBA Inferred from Biological aspect of Ancestor more info
located_in adherens junction	ISO Inferred from Sequence Orthology more info
located_in anchoring junction	IEA Inferred from Electronic Annotation more info
is_active_in cell-substrate junction	IBA Inferred from Biological aspect of Ancestor more info
located_in cell-substrate junction	IDA Inferred from Direct Assay more info	PubMed
located_in costamere	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytoplasmic side of plasma membrane	ISO Inferred from Sequence Orthology more info
located_in cytoskeleton	IEA Inferred from Electronic Annotation more info
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info
part_of dystrophin-associated glycoprotein complex	IDA Inferred from Direct Assay more info	PubMed
located_in focal adhesion	ISO Inferred from Sequence Orthology more info
located_in intercalated disc	ISO Inferred from Sequence Orthology more info
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
is_active_in sarcolemma	IBA Inferred from Biological aspect of Ancestor more info
located_in sarcolemma	IDA Inferred from Direct Assay more info	PubMed
located_in sarcolemma	ISO Inferred from Sequence Orthology more info
located_in spot adherens junction	ISO Inferred from Sequence Orthology more info
located_in stress fiber	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: phosphoglucomutase-like protein 5

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_175013.2 → NP_778178.3 phosphoglucomutase-like protein 5

See identical proteins and their annotated locations for NP_778178.3

Status: VALIDATED

Source sequence(s)

AC151413, AK035507

Consensus CDS

CCDS29714.1

UniProtKB/Swiss-Prot

Q8BZF8

Related

ENSMUSP00000036025.5, ENSMUST00000047666.5

Conserved Domains (1) summary

cl03757
Location:10 → 567

phosphohexomutase; The alpha-D-phosphohexomutase superfamily includes several related enzymes that catalyze a reversible intramolecular phosphoryl transfer on their sugar substrates. Members of this family include the phosphoglucomutases (PGM1 and PGM2), phosphoglucosamine ...