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    Slc9c1 solute carrier family 9, subfamily C (Na+-transporting carboxylic acid decarboxylase), member 1 [ Mus musculus (house mouse) ]

    Gene ID: 208169, updated on 11-Apr-2024

    Summary

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    Official Symbol
    Slc9c1provided by MGI
    Official Full Name
    solute carrier family 9, subfamily C (Na+-transporting carboxylic acid decarboxylase), member 1provided by MGI
    Primary source
    MGI:MGI:2685456
    See related
    Ensembl:ENSMUSG00000033210 AllianceGenome:MGI:2685456
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    sNHE; Gm610; NHE-10; Slc9a10; spermNHE
    Summary
    Predicted to enable potassium:proton antiporter activity and sodium:proton antiporter activity. Acts upstream of or within flagellated sperm motility. Located in motile cilium. Orthologous to human SLC9C1 (solute carrier family 9 member C1). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Restricted expression toward testis adult (RPKM 10.4) See more
    Orthologs
    human all
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    Genomic context

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    See Slc9c1 in Genome Data Viewer
    Location:
    16 B5; 16 29.53 cM
    Exon count:
    28
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 16 NC_000082.7 (45355629..45427364)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 16 NC_000082.6 (45535266..45607001)

    Chromosome 16 - NC_000082.7Genomic Context describing neighboring genes Neighboring gene CD200 molecule like 2 Neighboring gene TNF receptor associated factor 4 pseudogene Neighboring gene germinal center associated, signaling and motility Neighboring gene cDNA sequence, BC016579

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Hyperpolarization induces cytosolic alkalization of mouse sperm flagellum probably through sperm Na+/H+ exchanger. Hernández-Garduño S, et al. Reproduction, 2022 Oct 1. PMID 35900329
    2. Controlling fertilization and cAMP signaling in sperm by optogenetics. Jansen V, et al. Elife, 2015 Jan 20. PMID 25601414, Free PMC Article
    3. A sperm-specific Na+/H+ exchanger (sNHE) is critical for expression and in vivo bicarbonate regulation of the soluble adenylyl cyclase (sAC). Wang D, et al. Proc Natl Acad Sci U S A, 2007 May 29. PMID 17517652, Free PMC Article
    4. A new sperm-specific Na+/H+ exchanger required for sperm motility and fertility. Wang D, et al. Nat Cell Biol, 2003 Dec. PMID 14634667
    5. Molecular Mechanism Underlying the Action of Zona-pellucida Glycoproteins on Mouse Sperm. Balbach M, et al. Front Cell Dev Biol, 2020. PMID 32984353, Free PMC Article

    See all (16) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. sperm-specific Na+/H+ exchanger is required for the expression of full-length soluble adenylyl cyclase
      Title: A sperm-specific Na+/H+ exchanger (sNHE) is critical for expression and in vivo bicarbonate regulation of the soluble adenylyl cyclase (sAC).
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables antiporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables monoatomic ion channel activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables potassium:proton antiporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables sodium:proton antiporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables sodium:proton antiporter activity TAS
    Traceable Author Statement
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within cell differentiation IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within flagellated sperm motility IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in monoatomic cation transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within monoatomic ion transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in monoatomic ion transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within multicellular organism development IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in potassium ion transmembrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in proton transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of intracellular pH IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in sodium ion import across plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within sodium ion transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within spermatogenesis IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cell projection IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in ciliary membrane TAS
    Traceable Author Statement
    more info
    		  
    located_in cilium IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in motile cilium IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    sodium/hydrogen exchanger 10
    Names
    Na(+)/H(+) exchanger 10
    solute carrier family 10 member 10
    solute carrier family 9 member C1
    solute carrier family 9, member 10
    sperm-specific Na(+)/H(+) exchanger
    sperm-specific sodium proton exchanger

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_198106.4 → NP_932774.3  sodium/hydrogen exchanger 10

      See identical proteins and their annotated locations for NP_932774.3

      Status: VALIDATED

      Source sequence(s)
      AC124636
      Consensus CDS
      CCDS28198.2
      UniProtKB/Swiss-Prot
      E0CX34, Q6UJY2, Q7M6Y7
      Related
      ENSMUSP00000124969.2, ENSMUST00000159945.8
      Conserved Domains (3) summary
      COG0664
      Location:885 → 1035
      Crp; cAMP-binding domain of CRP or a regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]
      cd00038
      Location:895 → 1019
      CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...
      cl01133
      Location:40 → 459
      Na_H_Exchanger; Sodium/hydrogen exchanger family

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000082.7 Reference GRCm39 C57BL/6J

      Range
      45355629..45427364
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017316906.2 → XP_017172395.1  sodium/hydrogen exchanger 10 isoform X3

      Conserved Domains (2) summary
      cd00038
      Location:847 → 971
      CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...
      cl01133
      Location:41 → 309
      Na_H_Exchanger; Sodium/hydrogen exchanger family

    2. XM_017316905.2 → XP_017172394.1  sodium/hydrogen exchanger 10 isoform X2

      Conserved Domains (2) summary
      cd00038
      Location:853 → 977
      CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...
      cl01133
      Location:40 → 417
      Na_H_Exchanger; Sodium/hydrogen exchanger family

    3. XM_017316904.2 → XP_017172393.1  sodium/hydrogen exchanger 10 isoform X1

      Conserved Domains (2) summary
      cd00038
      Location:874 → 998
      CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...
      cl01133
      Location:40 → 438
      Na_H_Exchanger; Sodium/hydrogen exchanger family
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q6UJY2.3 GenPept UniProtKB/Swiss-Prot:Q6UJY2

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