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    ppt-1 Palmitoyl-protein thioesterase 1 [ Caenorhabditis elegans ]

    Gene ID: 191744, updated on 11-Apr-2024

    Summary

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    Gene symbol
    ppt-1
    Gene description
    Palmitoyl-protein thioesterase 1
    Primary source
    WormBase:WBGene00004092
    Locus tag
    CELE_F44C4.5
    See related
    AllianceGenome:WB:WBGene00004092
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Enables palmitoyl-(protein) hydrolase activity. Involved in several processes, including cellular protein catabolic process; mitochondrion organization; and oviposition. Predicted to be active in lysosome. Used to study neuronal ceroid lipofuscinosis. Human ortholog(s) of this gene implicated in neuronal ceroid lipofuscinosis 1. Orthologous to human PPT1 (palmitoyl-protein thioesterase 1). [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    Location:
    chromosome: V
    Exon count:
    6
    Sequence:
    Chromosome: V; NC_003283.11 (6624701..6626344, complement)

    Chromosome V - NC_003283.11Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene Nuclear Hormone Receptor family Neighboring gene ncRNA Neighboring gene ALK tyrosine kinase receptor homolog scd-2 Neighboring gene G_PROTEIN_RECEP_F1_2 domain-containing protein Neighboring gene EF-hand domain-containing protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003283.11

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Identification and characterization of Caenorhabditis elegans palmitoyl protein thioesterase1. Porter MY, et al. J Neurosci Res, 2005 Mar 15. PMID 15672447
    2. A systematic analysis of protein palmitoylation in Caenorhabditis elegans. Edmonds MJ, et al. BMC Genomics, 2014 Oct 2. PMID 25277130, Free PMC Article
    3. Subcellular Nanorheology Reveals Lysosomal Viscosity as a Reporter for Lysosomal Storage Diseases. Devany J, et al. Nano Lett, 2018 Feb 14. PMID 29313356
    4. Comparative genomics and functional study of lipid metabolic genes in Caenorhabditis elegans. Zhang Y, et al. BMC Genomics, 2013 Mar 12. PMID 23496871, Free PMC Article
    5. Novel LOTUS-domain proteins are organizational hubs that recruit C. elegans Vasa to germ granules. Cipriani PG, et al. Elife, 2021 Jul 5. PMID 34223818, Free PMC Article

    See all (9) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables palmitoyl hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables palmitoyl-(protein) hydrolase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables palmitoyl-(protein) hydrolase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables palmitoyl-(protein) hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in egg-laying behavior IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in macromolecule depalmitoylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in mitochondrion organization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in post-embryonic development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein catabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein depalmitoylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in receptor-mediated endocytosis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in lysosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in lysosome ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    Palmitoyl-protein thioesterase 1
    NP_504684.2
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003283.11 Reference assembly

      Range
      6624701..6626344 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_072283.6 → NP_504684.2  Palmitoyl-protein thioesterase 1 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_504684.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q20390, Q68GX0
      Conserved Domains (1) summary
      cl21494
      Location:25 → 293
      Abhydrolase; alpha/beta hydrolases
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q20390.2

    Gene LinkOut

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