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    Mllt10 myeloid/lymphoid or mixed-lineage leukemia; translocated to, 10 [ Mus musculus (house mouse) ]

    Gene ID: 17354, updated on 23-Apr-2024

    Summary

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    Official Symbol
    Mllt10provided by MGI
    Official Full Name
    myeloid/lymphoid or mixed-lineage leukemia; translocated to, 10provided by MGI
    Primary source
    MGI:MGI:1329038
    See related
    Ensembl:ENSMUSG00000026743 AllianceGenome:MGI:1329038
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Af10; mKIAA4140; B130021D15Rik; D630001B22Rik
    Summary
    Predicted to enable histone binding activity and nucleosome binding activity. Predicted to be involved in positive regulation of transcription by RNA polymerase II. Predicted to be located in cytosol and nucleoplasm. Predicted to be part of protein-containing complex. Predicted to be active in nucleus. Is expressed in several structures, including branchial arch; early conceptus; genitourinary system; limb; and maxillary process. Human ortholog(s) of this gene implicated in acute monocytic leukemia and acute myeloid leukemia. Orthologous to human MLLT10 (MLLT10 histone lysine methyltransferase DOT1L cofactor). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in testis adult (RPKM 23.6), thymus adult (RPKM 9.8) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    2 A3; 2 12.84 cM
    Exon count:
    30
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (18059971..18217201)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (18055160..18212390)

    Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA A930004D18 gene Neighboring gene CapStarr-seq enhancer MGSCv37_chr2:17949221-17949330 Neighboring gene STARR-positive B cell enhancer ABC_E11122 Neighboring gene predicted gene, 33085 Neighboring gene predicted gene, 17762 Neighboring gene SKI/DACH domain containing 1 Neighboring gene microRNA 7655 Neighboring gene STARR-seq mESC enhancer starr_03800 Neighboring gene predicted gene, 25147 Neighboring gene heterogeneous nuclear ribonucleoprotein A3 pseudogene Neighboring gene DnaJ heat shock protein family (Hsp40) member C1 Neighboring gene GAR1 ribonucleoprotein homolog pseudogene Neighboring gene STARR-seq mESC enhancer starr_03801 Neighboring gene STARR-seq mESC enhancer starr_03802 Neighboring gene STARR-positive B cell enhancer ABC_E11123 Neighboring gene STARR-seq mESC enhancer starr_03803 Neighboring gene STARR-seq mESC enhancer starr_03805 Neighboring gene STARR-seq mESC enhancer starr_03806 Neighboring gene CapStarr-seq enhancer MGSCv37_chr2:18424168-18424351 Neighboring gene STARR-seq mESC enhancer starr_03808 Neighboring gene STARR-seq mESC enhancer starr_03809 Neighboring gene STARR-seq mESC enhancer starr_03810 Neighboring gene nuclear encoded tRNA asparagine 9 (anticodon GTT)

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. The DOT1L-MLLT10 complex regulates male fertility and promotes histone removal during spermiogenesis. Lin H, et al. Development, 2023 May 1. PMID 37082953,
    2. The role of the PZP domain of AF10 in acute leukemia driven by AF10 translocations. Klein BJ, et al. Nat Commun, 2021 Jul 5. PMID 34226546, Free PMC Article
    3. MLLT10 promotes tumor migration, invasion, and metastasis in human colorectal cancer. Jing X, et al. Scand J Gastroenterol, 2018 Aug. PMID 30102091
    4. Nuclear export signal within CALM is necessary for CALM-AF10-induced leukemia. Suzuki M, et al. Cancer Sci, 2014 Mar. PMID 24397609, Free PMC Article
    5. The clathrin-binding domain of CALM and the OM-LZ domain of AF10 are sufficient to induce acute myeloid leukemia in mice. Deshpande AJ, et al. Leukemia, 2011 Nov. PMID 21681188

    See all (38) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The DOT1L-MLLT10 complex regulates male fertility and promotes histone removal during spermiogenesis.
      Title: The DOT1L-MLLT10 complex regulates male fertility and promotes histone removal during spermiogenesis.
    2. The role of the PZP domain of AF10 in acute leukemia driven by AF10 translocations.
      Title: The role of the PZP domain of AF10 in acute leukemia driven by AF10 translocations.
    3. Together these data are the first to demonstrate that Af10-dependent H3K79me is essential for development of nasal processes and adjacent tissues, and consequent midfacial formation.
      Title: Mllt10 knockout mouse model reveals critical role of Af10-dependent H3K79 methylation in midfacial development.
    4. In lung metastasis sites, the knockdown of MLLT10 in SW620 cells significantly inhibited Vimentin expression, whereas the E-Cadherin was increased. These results indicate that MLLT10 regulates the metastasis of CRC cells via EMT.
      Title: MLLT10 promotes tumor migration, invasion, and metastasis in human colorectal cancer.
    5. Results provide evidence that transformation driven by MLL fusions as well as the recurrent AML-associated NUP98-NSD1 fusion oncogene is critically dependent on the ability of AF10 to stimulate DOT1L activity.
      Title: AF10 regulates progressive H3K79 methylation and HOX gene expression in diverse AML subtypes.
    6. During leukemogenesis, CALM-AF10 plays critical roles in the cytoplasm.
      Title: Nuclear export signal within CALM is necessary for CALM-AF10-induced leukemia.
    7. In leukemia cells, full-length CALM-AF10 localized to the nucleus with no consistent effect on growth factor endocyctosis, and suppressed histone H3 lysine 79 methylation regardless of the presence of clathrin
      Title: The clathrin-binding domain of CALM-AF10 alters the phenotype of myeloid neoplasms in mice.
    8. further suggest that future approaches to antagonize CALM-AF10-induced transformation should incorporate strategies, which aim at blocking these key domains
      Title: The clathrin-binding domain of CALM and the OM-LZ domain of AF10 are sufficient to induce acute myeloid leukemia in mice.
    9. conclude that Mllt10/Af10-Dot1l are essential, largely dedicated activators of Wnt-dependent transcription, critical for maintenance of intestinal proliferation and homeostasis
      Title: The leukemia-associated Mllt10/Af10-Dot1l are Tcf4/β-catenin coactivators essential for intestinal homeostasis.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (1)  1 citation
    • Endonuclease-mediated (3) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • KIAA4140

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables chromatin binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables histone binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables histone binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nucleosome binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables nucleosome binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in positive regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    part_of protein-containing complex ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    protein AF-10
    Names
    myeloid/lymphoid or mixed lineage-leukemia translocation to 10 homolog
    myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 10

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001252560.1 → NP_001239489.1  protein AF-10 isoform 1

      See identical proteins and their annotated locations for NP_001239489.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes isoform 1. Variants 1 and 2 encode the same isoform.
      Source sequence(s)
      AL928557, AL928589
      Consensus CDS
      CCDS15708.1
      UniProtKB/Swiss-Prot
      O54826, Q6NS43
      UniProtKB/TrEMBL
      Q5DTL6
      Related
      ENSMUSP00000110328.3, ENSMUST00000114680.9
      Conserved Domains (2) summary
      cd15574
      Location:24 → 71
      PHD_AF10_AF17; PHD finger found in protein AF-10 and AF-17
      cd15708
      Location:78 → 206
      ePHD_AF10; Extended PHD finger found in protein AF-10 and similar proteins

    2. NM_001252561.1 → NP_001239490.1  protein AF-10 isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) includes an alternate exon and uses an alternate start codon, compared to variant 1. The encoded isoform (2) is shorter and has a distinct N-terminus, compared to isoform 1.
      Source sequence(s)
      AL928557, AL928589
      Consensus CDS
      CCDS57155.1
      UniProtKB/TrEMBL
      A2AS70, Q5DTL6
      Related
      ENSMUSP00000110319.2, ENSMUST00000114671.8
      Conserved Domains (2) summary
      cd15708
      Location:3 → 128
      ePHD_AF10; Extended PHD finger found in protein AF-10 and similar proteins
      cd20901
      Location:639 → 702
      CC_AF10; coiled coil domain of ALL1-Fused gene from chromosome 10 protein (AF10) and similar proteins

    3. NM_010804.4 → NP_034934.2  protein AF-10 isoform 1

      See identical proteins and their annotated locations for NP_034934.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1 and 2 encode the same isoform (1).
      Source sequence(s)
      BC070475, BY608946, CN534499, CN537566
      Consensus CDS
      CCDS15708.1
      UniProtKB/Swiss-Prot
      O54826, Q6NS43
      UniProtKB/TrEMBL
      Q5DTL6
      Related
      ENSMUSP00000028076.9, ENSMUST00000028076.15
      Conserved Domains (2) summary
      cd15574
      Location:24 → 71
      PHD_AF10_AF17; PHD finger found in protein AF-10 and AF-17
      cd15708
      Location:78 → 206
      ePHD_AF10; Extended PHD finger found in protein AF-10 and similar proteins

    RNA

    1. NR_045538.1 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) uses an alternate splice site compared to variant 1. This variant is represented as non-coding due to the presence of an upstream ORF that is predicted to interfere with translation of the longest ORF; translation of the upstream ORF renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AK045042, AK052207, AL928557, AL928589, BC070475

    2. NR_045539.1 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (5) uses an alternate splice site and contains two alternate internal exons, compared to variant 1. This variant is represented as non-coding due to the presence of an upstream ORF that is predicted to interfere with translation of the longest ORF; translation of the upstream ORF renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AL928557, AL928589

    3. NR_149308.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AK045042, AK158426, AL928557

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000068.8 Reference GRCm39 C57BL/6J

      Range
      18059971..18217201
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030248197.2 → XP_030104057.1  protein AF-10 isoform X13

      UniProtKB/TrEMBL
      Q5DTL6
      Conserved Domains (2) summary
      cd20901
      Location:598 → 661
      CC_AF10; coiled coil domain of ALL1-Fused gene from chromosome 10 protein (AF10) and similar proteins
      cl22851
      Location:1 → 87
      PHD_SF; PHD finger superfamily

    2. XM_030248200.2 → XP_030104060.1  protein AF-10 isoform X15

      UniProtKB/TrEMBL
      Q5DTL6
      Conserved Domains (2) summary
      cd20901
      Location:566 → 629
      CC_AF10; coiled coil domain of ALL1-Fused gene from chromosome 10 protein (AF10) and similar proteins
      cl22851
      Location:1 → 84
      PHD_SF; PHD finger superfamily

    3. XM_030248116.2 → XP_030103976.1  protein AF-10 isoform X1

      UniProtKB/TrEMBL
      Q5DTL6
      Conserved Domains (2) summary
      cd15574
      Location:24 → 71
      PHD_AF10_AF17; PHD finger found in protein AF-10 and AF-17
      cd15708
      Location:78 → 206
      ePHD_AF10; Extended PHD finger found in protein AF-10 and similar proteins

    4. XM_006497389.4 → XP_006497452.1  protein AF-10 isoform X15

      UniProtKB/TrEMBL
      Q5DTL6
      Conserved Domains (2) summary
      cd20901
      Location:566 → 629
      CC_AF10; coiled coil domain of ALL1-Fused gene from chromosome 10 protein (AF10) and similar proteins
      cl22851
      Location:1 → 84
      PHD_SF; PHD finger superfamily

    5. XM_006497390.4 → XP_006497453.1  protein AF-10 isoform X16

      UniProtKB/TrEMBL
      Q5DTL6
      Conserved Domains (1) summary
      cl22851
      Location:1 → 52
      PHD_SF; PHD finger superfamily

    6. XM_006497373.5 → XP_006497436.2  protein AF-10 isoform X1

      UniProtKB/TrEMBL
      Q5DTL6
      Conserved Domains (2) summary
      cd15574
      Location:24 → 71
      PHD_AF10_AF17; PHD finger found in protein AF-10 and AF-17
      cd15708
      Location:78 → 206
      ePHD_AF10; Extended PHD finger found in protein AF-10 and similar proteins

    7. XM_036159019.1 → XP_036014912.1  protein AF-10 isoform X2

      UniProtKB/TrEMBL
      Q5DTL6
      Conserved Domains (3) summary
      cd15574
      Location:24 → 71
      PHD_AF10_AF17; PHD finger found in protein AF-10 and AF-17
      cd15708
      Location:78 → 206
      ePHD_AF10; Extended PHD finger found in protein AF-10 and similar proteins
      cd20901
      Location:706 → 769
      CC_AF10; coiled coil domain of ALL1-Fused gene from chromosome 10 protein (AF10) and similar proteins

    8. XM_006497375.5 → XP_006497438.2  protein AF-10 isoform X3

      UniProtKB/TrEMBL
      Q5DTL6
      Conserved Domains (2) summary
      cd15574
      Location:24 → 71
      PHD_AF10_AF17; PHD finger found in protein AF-10 and AF-17
      cd15708
      Location:78 → 203
      ePHD_AF10; Extended PHD finger found in protein AF-10 and similar proteins

    9. XM_030248112.2 → XP_030103972.1  protein AF-10 isoform X6

      UniProtKB/TrEMBL
      Q5DTL6
      Conserved Domains (3) summary
      cd15574
      Location:24 → 71
      PHD_AF10_AF17; PHD finger found in protein AF-10 and AF-17
      cd20901
      Location:662 → 725
      CC_AF10; coiled coil domain of ALL1-Fused gene from chromosome 10 protein (AF10) and similar proteins
      cl22851
      Location:81 → 151
      PHD_SF; PHD finger superfamily

    10. XM_006497382.5 → XP_006497445.2  protein AF-10 isoform X5

      UniProtKB/TrEMBL
      Q5DTL6
      Conserved Domains (2) summary
      cd15574
      Location:24 → 71
      PHD_AF10_AF17; PHD finger found in protein AF-10 and AF-17
      cd15708
      Location:78 → 206
      ePHD_AF10; Extended PHD finger found in protein AF-10 and similar proteins

    11. XM_006497377.5 → XP_006497440.2  protein AF-10 isoform X4

      UniProtKB/Swiss-Prot
      O54826, Q6NS43
      UniProtKB/TrEMBL
      Q5DTL6
      Conserved Domains (2) summary
      cd15574
      Location:24 → 71
      PHD_AF10_AF17; PHD finger found in protein AF-10 and AF-17
      cd15708
      Location:78 → 206
      ePHD_AF10; Extended PHD finger found in protein AF-10 and similar proteins

    12. XM_017316073.3 → XP_017171562.1  protein AF-10 isoform X7

      UniProtKB/TrEMBL
      Q5DTL6
      Conserved Domains (3) summary
      sd00025
      Location:66 → 85
      zf-RanBP2; RanBP2-type Zn finger [structural motif]
      cd15574
      Location:24 → 71
      PHD_AF10_AF17; PHD finger found in protein AF-10 and AF-17
      cd15708
      Location:78 → 203
      ePHD_AF10; Extended PHD finger found in protein AF-10 and similar proteins

    13. XM_036159032.1 → XP_036014925.1  protein AF-10 isoform X9

      UniProtKB/TrEMBL
      Q5DTL6
      Conserved Domains (2) summary
      cd15708
      Location:3 → 128
      ePHD_AF10; Extended PHD finger found in protein AF-10 and similar proteins
      cd20901
      Location:639 → 702
      CC_AF10; coiled coil domain of ALL1-Fused gene from chromosome 10 protein (AF10) and similar proteins

    14. XM_030248136.2 → XP_030103996.1  protein AF-10 isoform X8

      UniProtKB/TrEMBL
      Q5DTL6
      Conserved Domains (2) summary
      cd15708
      Location:3 → 128
      ePHD_AF10; Extended PHD finger found in protein AF-10 and similar proteins
      cd20901
      Location:662 → 725
      CC_AF10; coiled coil domain of ALL1-Fused gene from chromosome 10 protein (AF10) and similar proteins

    15. XM_030248168.2 → XP_030104028.1  protein AF-10 isoform X9

      UniProtKB/TrEMBL
      Q5DTL6
      Conserved Domains (2) summary
      cd15708
      Location:3 → 128
      ePHD_AF10; Extended PHD finger found in protein AF-10 and similar proteins
      cd20901
      Location:639 → 702
      CC_AF10; coiled coil domain of ALL1-Fused gene from chromosome 10 protein (AF10) and similar proteins

    16. XM_036159035.1 → XP_036014928.1  protein AF-10 isoform X11

      UniProtKB/TrEMBL
      Q5DTL6
      Conserved Domains (2) summary
      cd15708
      Location:3 → 125
      ePHD_AF10; Extended PHD finger found in protein AF-10 and similar proteins
      cd20901
      Location:607 → 670
      CC_AF10; coiled coil domain of ALL1-Fused gene from chromosome 10 protein (AF10) and similar proteins

    17. XM_030248178.2 → XP_030104038.1  protein AF-10 isoform X9

      UniProtKB/TrEMBL
      Q5DTL6
      Conserved Domains (2) summary
      cd15708
      Location:3 → 128
      ePHD_AF10; Extended PHD finger found in protein AF-10 and similar proteins
      cd20901
      Location:639 → 702
      CC_AF10; coiled coil domain of ALL1-Fused gene from chromosome 10 protein (AF10) and similar proteins

    18. XM_030248113.2 → XP_030103973.1  protein AF-10 isoform X1

      UniProtKB/TrEMBL
      Q5DTL6
      Conserved Domains (2) summary
      cd15574
      Location:24 → 71
      PHD_AF10_AF17; PHD finger found in protein AF-10 and AF-17
      cd15708
      Location:78 → 206
      ePHD_AF10; Extended PHD finger found in protein AF-10 and similar proteins

    19. XM_030248120.2 → XP_030103980.1  protein AF-10 isoform X3

      UniProtKB/TrEMBL
      Q5DTL6
      Conserved Domains (2) summary
      cd15574
      Location:24 → 71
      PHD_AF10_AF17; PHD finger found in protein AF-10 and AF-17
      cd15708
      Location:78 → 203
      ePHD_AF10; Extended PHD finger found in protein AF-10 and similar proteins

    20. XM_036159034.1 → XP_036014927.1  protein AF-10 isoform X10

      UniProtKB/TrEMBL
      Q5DTL6
      Conserved Domains (3) summary
      cd15574
      Location:24 → 71
      PHD_AF10_AF17; PHD finger found in protein AF-10 and AF-17
      cd20901
      Location:630 → 693
      CC_AF10; coiled coil domain of ALL1-Fused gene from chromosome 10 protein (AF10) and similar proteins
      cl22851
      Location:81 → 148
      PHD_SF; PHD finger superfamily

    21. XM_036159027.1 → XP_036014920.1  protein AF-10 isoform X8

      UniProtKB/TrEMBL
      Q5DTL6
      Conserved Domains (2) summary
      cd15708
      Location:3 → 128
      ePHD_AF10; Extended PHD finger found in protein AF-10 and similar proteins
      cd20901
      Location:662 → 725
      CC_AF10; coiled coil domain of ALL1-Fused gene from chromosome 10 protein (AF10) and similar proteins

    22. XM_030248154.2 → XP_030104014.1  protein AF-10 isoform X8

      UniProtKB/TrEMBL
      Q5DTL6
      Conserved Domains (2) summary
      cd15708
      Location:3 → 128
      ePHD_AF10; Extended PHD finger found in protein AF-10 and similar proteins
      cd20901
      Location:662 → 725
      CC_AF10; coiled coil domain of ALL1-Fused gene from chromosome 10 protein (AF10) and similar proteins

    23. XM_030248187.2 → XP_030104047.1  protein AF-10 isoform X9

      UniProtKB/TrEMBL
      Q5DTL6
      Conserved Domains (2) summary
      cd15708
      Location:3 → 128
      ePHD_AF10; Extended PHD finger found in protein AF-10 and similar proteins
      cd20901
      Location:639 → 702
      CC_AF10; coiled coil domain of ALL1-Fused gene from chromosome 10 protein (AF10) and similar proteins

    24. XM_036159033.1 → XP_036014926.1  protein AF-10 isoform X9

      UniProtKB/TrEMBL
      Q5DTL6
      Conserved Domains (2) summary
      cd15708
      Location:3 → 128
      ePHD_AF10; Extended PHD finger found in protein AF-10 and similar proteins
      cd20901
      Location:639 → 702
      CC_AF10; coiled coil domain of ALL1-Fused gene from chromosome 10 protein (AF10) and similar proteins

    25. XM_030248193.2 → XP_030104053.1  protein AF-10 isoform X11

      UniProtKB/TrEMBL
      Q5DTL6
      Conserved Domains (2) summary
      cd15708
      Location:3 → 125
      ePHD_AF10; Extended PHD finger found in protein AF-10 and similar proteins
      cd20901
      Location:607 → 670
      CC_AF10; coiled coil domain of ALL1-Fused gene from chromosome 10 protein (AF10) and similar proteins

    26. XM_030248114.2 → XP_030103974.1  protein AF-10 isoform X1

      UniProtKB/TrEMBL
      Q5DTL6
      Conserved Domains (2) summary
      cd15574
      Location:24 → 71
      PHD_AF10_AF17; PHD finger found in protein AF-10 and AF-17
      cd15708
      Location:78 → 206
      ePHD_AF10; Extended PHD finger found in protein AF-10 and similar proteins

    27. XM_030248127.2 → XP_030103987.1  protein AF-10 isoform X3

      UniProtKB/TrEMBL
      Q5DTL6
      Conserved Domains (2) summary
      cd15574
      Location:24 → 71
      PHD_AF10_AF17; PHD finger found in protein AF-10 and AF-17
      cd15708
      Location:78 → 203
      ePHD_AF10; Extended PHD finger found in protein AF-10 and similar proteins

    28. XM_036159031.1 → XP_036014924.1  protein AF-10 isoform X6

      UniProtKB/TrEMBL
      Q5DTL6
      Conserved Domains (3) summary
      cd15574
      Location:24 → 71
      PHD_AF10_AF17; PHD finger found in protein AF-10 and AF-17
      cd20901
      Location:662 → 725
      CC_AF10; coiled coil domain of ALL1-Fused gene from chromosome 10 protein (AF10) and similar proteins
      cl22851
      Location:81 → 151
      PHD_SF; PHD finger superfamily

    29. XM_030248156.2 → XP_030104016.1  protein AF-10 isoform X8

      UniProtKB/TrEMBL
      Q5DTL6
      Conserved Domains (2) summary
      cd15708
      Location:3 → 128
      ePHD_AF10; Extended PHD finger found in protein AF-10 and similar proteins
      cd20901
      Location:662 → 725
      CC_AF10; coiled coil domain of ALL1-Fused gene from chromosome 10 protein (AF10) and similar proteins

    30. XM_036159037.1 → XP_036014930.1  protein AF-10 isoform X13

      UniProtKB/TrEMBL
      Q5DTL6
      Conserved Domains (2) summary
      cd20901
      Location:598 → 661
      CC_AF10; coiled coil domain of ALL1-Fused gene from chromosome 10 protein (AF10) and similar proteins
      cl22851
      Location:1 → 87
      PHD_SF; PHD finger superfamily

    31. XM_036159048.1 → XP_036014941.1  protein AF-10 isoform X17

      UniProtKB/TrEMBL
      Q5DTL6
      Conserved Domains (2) summary
      cd20901
      Location:552 → 615
      CC_AF10; coiled coil domain of ALL1-Fused gene from chromosome 10 protein (AF10) and similar proteins
      cl22851
      Location:3 → 70
      PHD_SF; PHD finger superfamily

    32. XM_030248195.2 → XP_030104055.1  protein AF-10 isoform X13

      UniProtKB/TrEMBL
      Q5DTL6
      Conserved Domains (2) summary
      cd20901
      Location:598 → 661
      CC_AF10; coiled coil domain of ALL1-Fused gene from chromosome 10 protein (AF10) and similar proteins
      cl22851
      Location:1 → 87
      PHD_SF; PHD finger superfamily

    33. XM_036159041.1 → XP_036014934.1  protein AF-10 isoform X15

      UniProtKB/TrEMBL
      Q5DTL6
      Conserved Domains (2) summary
      cd20901
      Location:566 → 629
      CC_AF10; coiled coil domain of ALL1-Fused gene from chromosome 10 protein (AF10) and similar proteins
      cl22851
      Location:1 → 84
      PHD_SF; PHD finger superfamily

    34. XM_036159038.1 → XP_036014931.1  protein AF-10 isoform X14

      UniProtKB/TrEMBL
      Q5DTL6
      Conserved Domains (2) summary
      cd20901
      Location:584 → 647
      CC_AF10; coiled coil domain of ALL1-Fused gene from chromosome 10 protein (AF10) and similar proteins
      cl22851
      Location:3 → 73
      PHD_SF; PHD finger superfamily

    35. XM_036159040.1 → XP_036014933.1  protein AF-10 isoform X15

      UniProtKB/TrEMBL
      Q5DTL6
      Conserved Domains (2) summary
      cd20901
      Location:566 → 629
      CC_AF10; coiled coil domain of ALL1-Fused gene from chromosome 10 protein (AF10) and similar proteins
      cl22851
      Location:1 → 84
      PHD_SF; PHD finger superfamily

    36. XM_036159044.1 → XP_036014937.1  protein AF-10 isoform X15

      UniProtKB/TrEMBL
      Q5DTL6
      Conserved Domains (2) summary
      cd20901
      Location:566 → 629
      CC_AF10; coiled coil domain of ALL1-Fused gene from chromosome 10 protein (AF10) and similar proteins
      cl22851
      Location:1 → 84
      PHD_SF; PHD finger superfamily

    37. XM_017316080.3 → XP_017171569.1  protein AF-10 isoform X16

      UniProtKB/TrEMBL
      Q5DTL6
      Conserved Domains (1) summary
      cl22851
      Location:1 → 52
      PHD_SF; PHD finger superfamily

    38. XM_036159039.1 → XP_036014932.1  protein AF-10 isoform X14

      UniProtKB/TrEMBL
      Q5DTL6
      Conserved Domains (2) summary
      cd20901
      Location:584 → 647
      CC_AF10; coiled coil domain of ALL1-Fused gene from chromosome 10 protein (AF10) and similar proteins
      cl22851
      Location:3 → 73
      PHD_SF; PHD finger superfamily

    39. XM_036159049.1 → XP_036014942.1  protein AF-10 isoform X17

      UniProtKB/TrEMBL
      Q5DTL6
      Conserved Domains (2) summary
      cd20901
      Location:552 → 615
      CC_AF10; coiled coil domain of ALL1-Fused gene from chromosome 10 protein (AF10) and similar proteins
      cl22851
      Location:3 → 70
      PHD_SF; PHD finger superfamily

    40. XM_030248196.2 → XP_030104056.1  protein AF-10 isoform X13

      UniProtKB/TrEMBL
      Q5DTL6
      Conserved Domains (2) summary
      cd20901
      Location:598 → 661
      CC_AF10; coiled coil domain of ALL1-Fused gene from chromosome 10 protein (AF10) and similar proteins
      cl22851
      Location:1 → 87
      PHD_SF; PHD finger superfamily

    41. XM_036159042.1 → XP_036014935.1  protein AF-10 isoform X15

      UniProtKB/TrEMBL
      Q5DTL6
      Conserved Domains (2) summary
      cd20901
      Location:566 → 629
      CC_AF10; coiled coil domain of ALL1-Fused gene from chromosome 10 protein (AF10) and similar proteins
      cl22851
      Location:1 → 84
      PHD_SF; PHD finger superfamily

    42. XM_030248194.2 → XP_030104054.1  protein AF-10 isoform X12

      UniProtKB/TrEMBL
      A2AS70, Q5DTL6
      Conserved Domains (2) summary
      cd15708
      Location:3 → 128
      ePHD_AF10; Extended PHD finger found in protein AF-10 and similar proteins
      cd20901
      Location:639 → 702
      CC_AF10; coiled coil domain of ALL1-Fused gene from chromosome 10 protein (AF10) and similar proteins

    43. XM_036159036.1 → XP_036014929.1  protein AF-10 isoform X12

      UniProtKB/TrEMBL
      A2AS70, Q5DTL6
      Conserved Domains (2) summary
      cd15708
      Location:3 → 128
      ePHD_AF10; Extended PHD finger found in protein AF-10 and similar proteins
      cd20901
      Location:639 → 702
      CC_AF10; coiled coil domain of ALL1-Fused gene from chromosome 10 protein (AF10) and similar proteins

    44. XM_030248210.2 → XP_030104070.1  protein AF-10 isoform X18

      UniProtKB/TrEMBL
      Q5DTL6
      Conserved Domains (1) summary
      cl22851
      Location:3 → 73
      PHD_SF; PHD finger superfamily
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O54826.2 GenPept UniProtKB/Swiss-Prot:O54826

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