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Aberrant methylation of the netrin-1 receptor genes UNC5C and DCC detected in advanced colorectal cancer. |
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Treatment with the demethylating agent 5-aza-2'-deoxycytidine, but not with the histone deacetylase inhibitor trichostatin A exclusively restored DCC expression in CRC cell lines. |
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DCC can be found in raft and non-raft portions of the plasma membrane. |
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the transcriptionally active TAp73alpha tumor suppressor is implicated in the apoptosis induced by netrin-1 in a p53-independent and DCC/ubiquitin-proteasome dependent manner. |
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Observational study of gene-disease association and gene-gene interaction. (HuGE Navigator) |
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DCC methylation is a frequent and cancer-specific event in primary ESCCs (esophageal squamous cell carcinoma), suggesting that DCC and associated pathways may represent a new diagnostical therapeutic target. |
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Multiple aberrations involving the DCC locus may play a role in the progression of nephroblastomas, and hence confer a poorer prognosis. |
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8. |
Observational study of gene-disease association and gene-environment interaction. (HuGE Navigator) |
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9. |
Observational study of gene-disease association. (HuGE Navigator) |
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10. |
study provides evidence that most colorectal cancers have alterations in both UNC5C and DCC netrin receptors; while UNC5C expression is regulated primarily via epigenetic regulation, DCC defects are mediated through allelic deletions |
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11. |
DCC is a putative conditional tumor-suppressor gene that is epigenetically inactivated by promoter hypermethylation in a majority of head-and-neck squamous cell carcinomas. |
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DCC in both commissural neurons and immortalized cells, is partially associated with cholesterol- and sphingolipid-enriched membrane domains named lipid rafts. |
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the localization of DCC to lipid rafts is a prerequisite for its proapoptotic activity, both in immortalized cells and in primary neurons |
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The netrin-1 receptor DCC promotes filopodia formation and cell spreading by activating Cdc42 and Rac1. |
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Deletions in this gene are found in colorectal and gastric cancers |
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Prognostic significance of the DCC gene protein expression in high-risk resected gastric carcinoma |
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DCC expression appears not to be predictive in poor survival outcome in patients with stage II or III colorectal cancer. |
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18. |
Altered expression of DCC protein is detectable in gastric carcinomas, an event that may have a role in the development of the disease. |
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DCC binds netrin through the fourth fibronectin type III domain. |
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20. |
data suggest that the codon 201 polymorphism of the DCC gene was a target of LOH, and predicted prognosis in colorectal cancer patients |
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21. |
Loss of dcc gene expression is associated with acute myelogenous leukemia |
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22. |
DCC binds to netrin, which regulates its interactions with heparin |
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23. |
Binding of netrin-1 to its receptors inhibits tumour suppressor p53-dependent apoptosis (review) |
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24. |
loss of DCC expression occurs in some colon adenomas, but is insufficient to drive the adenoma to carcinoma progression. |
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25. |
DCC/netrin-1 signaling may commit cells to the transition of endometrial gland architecture or function from a proliferating to a secretory phase. |
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26. |
The present study points to a potential influence of folates in regulating DCC expression at multiple levels involving post-transcriptional pathways. |
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27. |
Finds a linkage between the chromosome 18 near marker D18S851 at the third time point and the levels of HDL cholesterol in human males. |
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28. |
Overexpression of the DDC gene in the LNCaP prostate cancer cell line leads to differential expression of a total of 35 genes. |
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29. |
Results suggest that DCC could regulate cell adhesion and migration through its association with ERM-M (ezrin/radixin/moesin and merlin) proteins. |
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30. |
Patients with low nuclear DCC expression had a 3-year progression-free survival (PFS) rate of 0% compared with 33% of those with high DCC expression (P = 0.0067). |