Cfh complement factor H [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Cfhprovided by RGD
Official Full Name: complement factor Hprovided by RGD
Primary source: RGD:620428
See related: Ensembl:ENSRNOG00000030715 AllianceGenome:RGD:620428
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Fh; AMBP1; AMBP-1
Summary: Predicted to enable several functions, including complement component C3b binding activity; heparan sulfate proteoglycan binding activity; and heparin binding activity. Involved in several processes, including cellular response to hydrogen peroxide; cellular response to interferon-gamma; and cellular response to lipopolysaccharide. Located in several cellular components, including extracellular space; nucleus; and plasma membrane. Used to study atypical hemolytic-uremic syndrome. Biomarker of amphetamine abuse; membranous glomerulonephritis; obstructive jaundice; proteinuria (multiple); and retinal degeneration. Human ortholog(s) of this gene implicated in several diseases, including atypical hemolytic-uremic syndrome; eye disease (multiple); hemolytic-uremic syndrome; lupus nephritis; and systemic lupus erythematosus. Orthologous to several human genes including CFH (complement factor H). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Liver (RPKM 3870.5), Lung (RPKM 441.2) and 3 other tissues See more
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Genomic context

Location:: 13q13

Exon count:: 22

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	13	NC_086031.1 (54063079..54164523, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	13	NC_051348.1 (51512376..51613829, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	13	NC_005112.4 (56979155..57080540, complement)

Chromosome 13 - NC_086031.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

enhancive miR-146a could upregulate the expression of IL-1beta and downregulate the expression of CFH, whereas reductive miR-146a could downregulate the expression of IL-1beta and upregulate the expression of CFH, in hippocampi of chronic temporal lobe epilepsy rat models.
Title: The role of the microRNA-146a/complement factor H/interleukin-1β-mediated inflammatory loop circuit in the perpetuate inflammation of chronic temporal lobe epilepsy.
These findings suggest that immunopathological deficits associated with temporal lobe epilepsy (TLE) can in part be explained by a generalized miR-146a-mediated down-regulation of CFH that may contribute to epileptogenesis in a rat model of TLE.
Title: Modulation of miR-146a/complement factor H-mediated inflammatory responses in a rat model of temporal lobe epilepsy.
Factor h and properdin recognize different epitopes on renal tubular epithelial heparan sulfate.
Title: Factor h and properdin recognize different epitopes on renal tubular epithelial heparan sulfate.
molecular cloning, sequencing and quantification with a newly established ELISA
Title: Rat complement factor H: molecular cloning, sequencing and quantification with a newly established ELISA.
Complement Factor H is highly expressed in the brain where it could play important roles regulating adrenomedullin actions and contributing to an intracerebral complement system.
Title: Distribution of immunoreactivity for the adrenomedullin binding protein, complement factor H, in the rat brain.
Glomerular epithelial cells(GEC) and glomeruli express factor H mRNA and protein. Up-regulated in membranous nephropathy. Likely direct response of GEC to complement attack and may represent protective response.
Title: Rat glomerular epithelial cells produce and bear factor H on their surface that is up-regulated under complement attack.
expression and regulation in cultured heptocytes, Kupffer cells, and hepatoma cell lines
Title: Constitutive expression and regulation of rat complement factor H in primary cultures of hepatocytes, Kupffer cells, and two hepatoma cell lines.

Submit: New GeneRIF Correction

General gene information

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Markers

Cfh (e-PCR), detects polymorphism
- UniSTS:141324

RH130216 (e-PCR)
- UniSTS:213503

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables complement component C3b binding	IBA Inferred from Biological aspect of Ancestor more info
enables complement component C3b binding	ISO Inferred from Sequence Orthology more info
enables heparan sulfate proteoglycan binding	ISO Inferred from Sequence Orthology more info
enables heparin binding	ISO Inferred from Sequence Orthology more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within ATP metabolic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within activation of membrane attack complex	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within angiogenesis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within bone development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within cartilage development	ISO Inferred from Sequence Orthology more info
involved_in cellular response to hydrogen peroxide	IEP Inferred from Expression Pattern more info	PubMed
involved_in cellular response to lipopolysaccharide	IEP Inferred from Expression Pattern more info	PubMed
acts_upstream_of_or_within cellular response to lipopolysaccharide	ISO Inferred from Sequence Orthology more info
involved_in cellular response to type II interferon	IEP Inferred from Expression Pattern more info	PubMed
involved_in complement activation	IBA Inferred from Biological aspect of Ancestor more info
involved_in complement activation	IEP Inferred from Expression Pattern more info	PubMed
acts_upstream_of_or_within complement activation	ISO Inferred from Sequence Orthology more info
involved_in complement activation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within complement activation, alternative pathway	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within_negative_effect complement activation, alternative pathway	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within determination of adult lifespan	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within gene expression	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within glomerulus development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within immune complex clearance	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within immune response	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within immunoglobulin mediated immune response	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within inflammatory response	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within inflammatory response to wounding	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within kidney development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within mitochondrial DNA metabolic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within mitochondrial gene expression	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within mitochondrion organization	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within monocyte aggregation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within neuromuscular process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within neutrophil homeostasis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within organ or tissue specific immune response	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within organelle localization	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within photoreceptor cell differentiation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within platelet aggregation	ISO Inferred from Sequence Orthology more info
involved_in proteolysis	ISO Inferred from Sequence Orthology more info
involved_in regulation of complement activation	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within regulation of complement activation	ISO Inferred from Sequence Orthology more info
involved_in regulation of complement activation, alternative pathway	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of complement-dependent cytotoxicity	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within response to cytokine	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within response to dietary excess	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within retina development in camera-type eye	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within_positive_effect retina development in camera-type eye	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within retinal pigment epithelium development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within retinal rod cell development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within vascular associated smooth muscle cell differentiation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within visual perception	ISO Inferred from Sequence Orthology more info
involved_in visual perception	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in axon	ISO Inferred from Sequence Orthology more info
located_in external side of plasma membrane	ISO Inferred from Sequence Orthology more info
located_in extracellular region	ISO Inferred from Sequence Orthology more info
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info
located_in extracellular space	IDA Inferred from Direct Assay more info	PubMed
located_in extracellular space	ISO Inferred from Sequence Orthology more info
located_in mitochondrion	IEA Inferred from Electronic Annotation more info
located_in neuronal cell body	ISO Inferred from Sequence Orthology more info
part_of serine-type endopeptidase complex	ISO Inferred from Sequence Orthology more info
located_in symbiont cell surface	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: complement factor H

Names: adrenomedullin binding protein-1; complement component factor H; complement inhibitory factor H; platelet complement factor H

NP_569093.2

EC 4.2.1.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_130409.2 → NP_569093.2 complement factor H precursor

See identical proteins and their annotated locations for NP_569093.2

Status: PROVISIONAL

Source sequence(s)

AJ320522, BC083174, CB816813, CF110979, CK359694

UniProtKB/TrEMBL

A6ICN2, G3V9R2, Q91YB6

Related

ENSRNOP00000056859.2, ENSRNOT00000060111.5

Conserved Domains (4) summary

cd00033
Location:937 → 991

CCP; Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system

smart00032
Location:869 → 932

CCP; Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat (SCR)

PHA02927
Location:1 → 262

PHA02927; secreted complement-binding protein; Provisional

pfam00084
Location:810 → 863

Sushi; Sushi repeat (SCR repeat)