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    Gpd1 glycerol-3-phosphate dehydrogenase 1 (soluble) [ Mus musculus (house mouse) ]

    Gene ID: 14555, updated on 11-Apr-2024

    Summary

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    Official Symbol
    Gpd1provided by MGI
    Official Full Name
    glycerol-3-phosphate dehydrogenase 1 (soluble)provided by MGI
    Primary source
    MGI:MGI:95679
    See related
    Ensembl:ENSMUSG00000023019 AllianceGenome:MGI:95679
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Gdc1; GPD-C; Gdc-1; GPDH-C
    Summary
    Enables glycerol-3-phosphate dehydrogenase [NAD+] activity. Acts upstream of or within several processes, including cellular response to cAMP; gluconeogenesis; and glycerophosphate shuttle. Located in mitochondrion. Is expressed in several structures, including alimentary system; genitourinary system; integumental system; liver; and nervous system. Orthologous to human GPD1 (glycerol-3-phosphate dehydrogenase 1). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in mammary gland adult (RPKM 391.7), subcutaneous fat pad adult (RPKM 371.7) and 13 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Gpd1 in Genome Data Viewer
    Location:
    15 F1; 15 56.13 cM
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 15 NC_000081.7 (99615468..99622895)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 15 NC_000081.6 (99717587..99725014)

    Chromosome 15 - NC_000081.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_39720 Neighboring gene predicted gene, 34939 Neighboring gene SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 1 Neighboring gene ribosomal protein S27 pseudogene Neighboring gene predicted gene 16537 Neighboring gene CapStarr-seq enhancer MGSCv37_chr15:99555871-99556054 Neighboring gene cytochrome c oxidase assembly protein 14 Neighboring gene ceramide synthase 5

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. The enhancement of fat oxidation during the active phase and suppression of body weight gain in glycerol-3-phosphate dehydrogenase 1 deficient mice. Sato T, et al. Biosci Biotechnol Biochem, 2020 Nov. PMID 32662756
    2. Glycerol 3-phosphate dehydrogenase 1 deficiency enhances exercise capacity due to increased lipid oxidation during strenuous exercise. Sato T, et al. Biochem Biophys Res Commun, 2015 Feb 20. PMID 25603051
    3. The role of glycerol-3-phosphate dehydrogenase 1 in the progression of fatty liver after acute ethanol administration in mice. Sato T, et al. Biochem Biophys Res Commun, 2014 Feb 21. PMID 24472537
    4. Angiotensin II as a trophic factor of white adipose tissue: stimulation of adipose cell formation. Saint-Marc P, et al. Endocrinology, 2001 Jan. PMID 11145613
    5. Appearance of a second form of hepatic glycerol-3-phosphate dehydrogenase during neonatal development in the mouse. Chan AK, et al. Arch Biochem Biophys, 1981 Mar. PMID 6786227

    See all (81) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Non-bioenergetic roles of mitochondrial GPD2 promote tumor progression.
      Title: Non-bioenergetic roles of mitochondrial GPD2 promote tumor progression.
    2. The enhancement of fat oxidation during the active phase and suppression of body weight gain in glycerol-3-phosphate dehydrogenase 1 deficient mice.
      Title: The enhancement of fat oxidation during the active phase and suppression of body weight gain in glycerol-3-phosphate dehydrogenase 1 deficient mice.
    3. GPD1 null mice showed increased exercise capacity. Exercise-induced lipid oxidation was enhanced in GPD1 null mice.
      Title: Glycerol 3-phosphate dehydrogenase 1 deficiency enhances exercise capacity due to increased lipid oxidation during strenuous exercise.
    4. GPD1 and glycolytic gene expression is up-regulated by ethanol, and GPD1-mediated incorporation of glucose into triglycerides glycerol moieties together with increased lipogenesis plays a role in ethanol-induced hepatic triglycerides accumulation.
      Title: The role of glycerol-3-phosphate dehydrogenase 1 in the progression of fatty liver after acute ethanol administration in mice.
    5. Knockout mice deficient in both cytosolic and mitochondrial GPD have lethal hypoglycemic ketosis and glyceroluria.
      Title: Lethal hypoglycemic ketosis and glyceroluria in mice lacking both the mitochondrial and the cytosolic glycerol phosphate dehydrogenases.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Spontaneous (1)  1 citation
    • Endonuclease-mediated (3) 

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • KIAA4010

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables NAD binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables glycerol-3-phosphate dehydrogenase (quinone) activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables glycerol-3-phosphate dehydrogenase [NAD(P)+] activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables oxidoreductase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein homodimerization activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in NADH metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in NADH oxidation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within NADH oxidation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in NADH oxidation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in carbohydrate metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within cellular response to cAMP IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within cellular response to tumor necrosis factor IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within gluconeogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in glyceraldehyde-3-phosphate biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    involved_in glycerol-3-phosphate catabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in glycerol-3-phosphate metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within glycerol-3-phosphate metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in glycerol-3-phosphate metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in glycerolipid metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within glycerophosphate shuttle IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within positive regulation of glycolytic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of glycerol-3-phosphate dehydrogenase (FAD) complex TAS
    Traceable Author Statement
    more info
    		 PubMed 
    located_in mitochondrion HDA PubMed 

    General protein information

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    Preferred Names
    glycerol-3-phosphate dehydrogenase [NAD(+)], cytoplasmic
    Names
    glycerolphosphate dehydrogenase 1, cytoplasmic adult
    NP_034401.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_010271.3 → NP_034401.1  glycerol-3-phosphate dehydrogenase [NAD(+)], cytoplasmic

      See identical proteins and their annotated locations for NP_034401.1

      Status: VALIDATED

      Source sequence(s)
      AK018733, AK137134
      Consensus CDS
      CCDS27828.1
      UniProtKB/Swiss-Prot
      P13707, Q3UVM3, Q5DTS5
      UniProtKB/TrEMBL
      E0CXN5
      Related
      ENSMUSP00000023760.7, ENSMUST00000023760.13
      Conserved Domains (3) summary
      TIGR03376
      Location:5 → 342
      glycerol3P_DH; glycerol-3-phosphate dehydrogenase (NAD(+))
      pfam01210
      Location:5 → 172
      NAD_Gly3P_dh_N; NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus
      pfam07479
      Location:194 → 335
      NAD_Gly3P_dh_C; NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000081.7 Reference GRCm39 C57BL/6J

      Range
      99615468..99622895
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P13707.3 GenPept UniProtKB/Swiss-Prot:P13707

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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