Slc28a3 solute carrier family 28 member 3 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Slc28a3provided by RGD
Official Full Name: solute carrier family 28 member 3provided by RGD
Primary source: RGD:621224
See related: Ensembl:ENSRNOG00000018853 AllianceGenome:RGD:621224
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Cnt3
Summary: Predicted to enable purine-specific nucleoside:sodium symporter activity; pyrimidine- and adenine-specific:sodium symporter activity; and uridine transmembrane transporter activity. Involved in retina homeostasis. Predicted to be located in brush border membrane. Predicted to be integral component of plasma membrane. Orthologous to human SLC28A3 (solute carrier family 28 member 3). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Lung (RPKM 35.4) and Uterus (RPKM 8.4) See more
Orthologs: human mouse all
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Genomic context

Location:: 17p14

Exon count:: 18

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	17	NC_086035.1 (6068034..6120421)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	17	NC_051352.1 (6062563..6112965)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	17	NC_005116.4 (6459024..6509761)

Chromosome 17 - NC_086035.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

There is functional crosstalk between the adenosine transporter CNT3 and purinergic receptors in the cholangiocytes in rats.
Title: Functional crosstalk between the adenosine transporter CNT3 and purinergic receptors in the biliary epithelia.
Diabetes increased CNT1 and CNT3 expression in the glomerulus and insulin treatment decreased it.
Title: Expression of concentrative nucleoside transporters SLC28 (CNT1, CNT2, and CNT3) along the rat nephron: effect of diabetes.

Submit: New GeneRIF Correction

General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables purine-specific nucleoside:sodium symporter activity	IBA Inferred from Biological aspect of Ancestor more info
enables purine-specific nucleoside:sodium symporter activity	IEA Inferred from Electronic Annotation more info
enables purine-specific nucleoside:sodium symporter activity	ISO Inferred from Sequence Orthology more info
enables pyrimidine- and adenosine-specific:sodium symporter activity	IBA Inferred from Biological aspect of Ancestor more info
enables pyrimidine- and adenosine-specific:sodium symporter activity	IEA Inferred from Electronic Annotation more info
enables pyrimidine- and adenosine-specific:sodium symporter activity	ISO Inferred from Sequence Orthology more info
enables uridine transmembrane transporter activity	IEA Inferred from Electronic Annotation more info
enables uridine transmembrane transporter activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in nucleoside transmembrane transport	ISO Inferred from Sequence Orthology more info
involved_in purine nucleobase transmembrane transport	IEA Inferred from Electronic Annotation more info
involved_in purine nucleoside transmembrane transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in purine nucleoside transmembrane transport	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within purine nucleoside transmembrane transport	ISO Inferred from Sequence Orthology more info
involved_in pyrimidine nucleobase transport	IEA Inferred from Electronic Annotation more info
involved_in pyrimidine nucleoside transport	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within pyrimidine nucleoside transport	ISO Inferred from Sequence Orthology more info
involved_in pyrimidine-containing compound transmembrane transport	IEA Inferred from Electronic Annotation more info
involved_in pyrimidine-containing compound transmembrane transport	ISO Inferred from Sequence Orthology more info
involved_in retina homeostasis	IDA Inferred from Direct Assay more info	PubMed
involved_in sodium ion transmembrane transport	IEA Inferred from Electronic Annotation more info
involved_in uridine transmembrane transport	IEA Inferred from Electronic Annotation more info
involved_in uridine transmembrane transport	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in brush border membrane	IEA Inferred from Electronic Annotation more info
located_in brush border membrane	ISO Inferred from Sequence Orthology more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: solute carrier family 28 member 3

Names: CNT 3; concentrative Na(+)-nucleoside cotransporter 3; rCNT3; solute carrier family 28 (concentrative nucleoside transporter), member 3; solute carrier family 28 (sodium-coupled nucleoside transporter), member 3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_080908.2 → NP_543184.2 solute carrier family 28 member 3

Status: PROVISIONAL

Source sequence(s)

JAXUCZ010000017

UniProtKB/Swiss-Prot

Q8VIH3

UniProtKB/TrEMBL

A6KAJ7, G3V8H0

Related

ENSRNOP00000025745.1, ENSRNOT00000025745.4

Conserved Domains (1) summary

TIGR00804
Location:218 → 629

nupC; nucleoside transporter

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086035.1 Reference GRCr8

Range

6068034..6120421

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039095316.2 → XP_038951244.1 solute carrier family 28 member 3 isoform X1

UniProtKB/Swiss-Prot

Q8VIH3

Conserved Domains (1) summary

TIGR00804
Location:218 → 602

nupC; nucleoside transporter