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1. |
ADH1B was not associated with alcohol expectancies or drinking behavior. |
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2. |
ADH1B genotypes were not associated with and did not modify the effect of alcohol on biochemical tests or risk of liver disease. |
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3. |
Despite sufficient statistical power, there was no significant impact of ADH1B on the risk of breast cancer. |
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4. |
Alcohol drinkers carrying both ADH2 G allele and ALDH2 A allele have a higher risk of developing esophageal cancer. |
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5. |
ADH1B polymorphisms are associated with alcohol and tobacco consumption for younger aged esophageal squamous cell carcinoma. |
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6. |
Decreased alcohol dehydrogenase in keratoconus corneal fibroblasts represents a strong marker and possible mediator of keratoconus. |
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7. |
Alleles of ADH7 SNPs were associated with the early stages of alcohol metabolism, with additional effects in the ADH1A, ADH1B and ADH4 regions. |
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8. |
The allele frequency in Koreans were 80.3% for the ADH2 |
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9. |
Findings indicate that functional polymorphism of the gene coding for the ALDH enzyme affects the propensity to develop alcohol dependence. and decreasing the rate of metabolism respectively, thus interacting additively but not synergistically. |
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10. |
review on recent advances in genomic studies of human ADH1B families and alcoholism. |
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11. |
Current data lend support to a role of polymorphisms ADH1B and ALDH2 combined with alcohol consumption in cancer |
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12. |
ADH1B-Arg48His polymorphism affects both alcohol-related flushing in Europeans and alcohol intake. |
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13. |
ALDH2 and ADH1B polymorphisms were associated with changes in blood catecholamine levels and cardiovascular measures after alcohol ingestion. |
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14. |
The fast metabolizing ADH1b 47his allele seemed to be associated with nondrinking in a Caucasian population |
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15. |
ADH1b47his allele frequency is different for European regions. |
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16. |
A high frequency of the ADH1B*47His allele is strongly correlated with certain eastern ethnic groups. |
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17. |
The ADH1B*47His polymorphism reaches high frequencies only in western and eastern Asia |
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18. |
Polymorphisms of the ADH2 and ALDH2 genes are significantly associated with colorectal cancer risk in Chinese males |
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19. |
Variants of this alcohol-metabolizing enzyme appeared in the relation to alcoholic chronic pancreatitis |
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20. |
Genetic polymorphism of the gene is substantially involving in individual variation of susceptibility to alcohol dependence. |
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21. |
Alcohol consumption and polymorphisms in the CYP2E1, ADH1B and ALDH2 genes are important risk factors for esophageal squamous cell carcinoma in Chinese males living in Gansu Province, China. |
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22. |
men and women with ADH1B slow vs fast alcohol degradation drank more alcohol and had a higher risk of everyday drinking, heavy drinking, excessive drinking and of alcoholism. |
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23. |
Single Nucleotide Polymorphism in ADH1B gene is associated with upper aerodigestive cancer. |
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24. |
describes demographic, alcohol use, country of origin, family history of alcohol dependence, and ALDH2 and ADH1b variables to elucidate response to alcohol amont Chinese and Korean-American college students |
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25. |
The low activity ALDH2*2 allele was significantly associated with increased risk for oesophageal cancer amongst the Black subjects |
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26. |
In Japanese men with alcohol dehydrogenase 2*1/1 genotype there was a higher fasting plasma glucose level compared to those without the genotype. |
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27. |
the interplay of the ADH1B and ALDH2 genotypes, in conjunction with a behaved drinking habit and a practiced drinking pattern, along with continued tobacco consumption, plays an important pathogenic role in modulating esophageal SCC risk |
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28. |
erythema following alcohol exposure is alcohol type specific, has a pharmacogenetic basis related to ADHIB haplotype |
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29. |
Observational study, meta-analysis, and HuGE review of genotype prevalence, gene-disease association, and gene-environment interaction. (HuGE Navigator) |
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30. |
Observational study of genetic testing. (HuGE Navigator) |
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31. |
Meta-analysis of gene-disease association. (HuGE Navigator) |
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32. |
Observational study of genotype prevalence and gene-disease association. (HuGE Navigator) |
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33. |
Observational study of genotype prevalence and gene-environment interaction. (HuGE Navigator) |
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34. |
Meta-analysis and HuGE review of gene-disease association. (HuGE Navigator) |
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35. |
Observational study of gene-disease association, gene-gene interaction, and gene-environment interaction. (HuGE Navigator) |
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36. |
Observational study of genotype prevalence. (HuGE Navigator) |
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37. |
Observational study of gene-disease association and gene-environment interaction. (HuGE Navigator) |
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38. |
Observational study of gene-disease association and gene-gene interaction. (HuGE Navigator) |
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39. |
Observational study of gene-disease association. (HuGE Navigator) |
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40. |
Polymorphisms in ADH1B is associated with breast cancer |
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41. |
ADH2 and ALDH2 genotypes are associated with esophageal cancer risk. ADH2 1 allele and ALDH2 2 allele carriers have a much higher risk of developing esophageal cancer, especially among alcohol drinkers. |
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42. |
the eNOS gene T-786C mutation and the fast form of ADH2 Arg47His polymorphism may have an additive interaction on the risk of premature coronary artery disease in Chinese population |
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43. |
This study suggests that the ALDH2*A allele status may correlate with variations in alcohol consumption patterns among Jews, independent of the effect of ADH1B genotype. |
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44. |
Alcohol dehydrogenase 2 genotype and allelic variants are not associated with the risk for essential tremor. |
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45. |
Higher levels of ethanol persisted in the blood for longer periods in ADH1B*1/*1 carriers (n = 25) than in ADH1B*2 allele carriers after adjustment for the amount and time of the preceding alcohol consumption and body weight |
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46. |
increased risk of fetal alcohol syndrome for the maternal and possibly fetal ADH1B/ADH1B genotype |
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47. |
Risk of cerebral infarction is increased by the ADH2*1 allele. |
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48. |
Effect modification suggested of association between alcohol consumption and breast cancer risk by ADH1B genotype |
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49. |
polymorphisms in ADH1C and ADH1B may have roles in the risk of alcoholism |
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50. |
Sructural aspects that influence dimer-tetramer formation |
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51. |
Polymorphisms of the alcohol metabolism-related ADH2 gene are significantly different in Korean patients with alcoholism and Korean control subjects without alcoholism. |
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52. |
The alcohol-BP relationship was significantly stronger in men with ADH21/21 than in men with ADH21/22 or 22/22 in this Japanese rural population. |
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53. |
Heterozygous alcohol dehydrogenase 2 genotype (ADH2*1/2*2) exhibited an association with the scant pancreatitis subgroup (P = 0.02). |
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54. |
No effects of the ADH1B*47His alleles on in vivo ethanol metabolism were observed. This implies that there is a major determinant of variation for in vivo alcohol metabolism in the ADH region that is not accounted for by this polymorphism. |
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55. |
There is no significant interaction between alcohol consumption and ADH2 genotype. |
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56. |
The metabolism of all-trans- and 9-cis-retinol/ retinaldehyde has been investigated with focus on the activities of human, mouse and rat alcohol dehydrogenase 2 (ADH2), an intriguing enzyme with apparently different functions in human and rodents. |
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57. |
47Arg polymorphism in the ADH2 may act to suppress osteophyte formation unaffected by disc degeneration |
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58. |
There was a gene-environment interaction between the ADH2 polymorphism, alcohol consumption, and breast cancer risk. Breast cancer risk associated with alcohol consumption vary with the ADH2 polymorphism, probably due to differences in EtOH metabolism. |
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59. |
Polymorphisms of alcohol-metabolizing enzymes: analyses of mutations on the CYP2E1, ADH2, ADH3 and ALDH2 genes in a Mexican-American population living in the Los Angeles area. |
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60. |
The ADH1B gene may interact with the dopamine D2 receptor (DRD2) gene in the development of anxiety-depressive alcohol dependence in the Taiwan Han Chinese population. |
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61. |
interaction between ALDH2 and ADH2 polymorphisms may have a role in colorectal cancer in Japan |
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62. |
Results suggest that ADH1B polymorphisms play a pivotal role on esophageal cancer and that the effect of these polymorphisms was modified by the amount of alcohol consumed. |
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63. |
Data are consistent with the hypothesis that the maternal ADH1B*3 allele provides some protection to the fetus from prenatal alcohol exposure. |
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64. |
ADH1B*2 allele has been associated with lowr rates of alcohol dependence. |
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65. |
findings suggest that the alcohol dehydrogenase IB and IC genes are regulated by epigenetic mechanisms in human hepatoma cells |
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66. |
Results suggest, in this sample of Trinidadians, that the ADH1B(*)3 allele is associated with protection from the development of alcoholism and enhanced risk for elevated serum ALT levels in those individuals who do become alcohol dependent. |
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67. |
The ADH2*2 allele protects against alcohol dependence severity in Jewish samples. |
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68. |
Polymorphism is not associated with laryngeal cancer risk in Caucasians. |
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69. |
Mutations that contribute to the risk of alcoholism affect European, Chinese, and Japanese populations differently. |
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70. |
Genetic polymorphisms of ADH1B is associated with oral and pharyngeal squamous cell carcinoma |
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71. |
Low levels of alcohol are associated with a modest increase in breast cancer risk that is not altered by known functional allelic variants of the ADH1B gene. |