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    Slc22a7 solute carrier family 22 (organic anion transporter), member 7 [ Mus musculus (house mouse) ]

    Gene ID: 108114, updated on 11-Apr-2024

    Summary

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    Official Symbol
    Slc22a7provided by MGI
    Official Full Name
    solute carrier family 22 (organic anion transporter), member 7provided by MGI
    Primary source
    MGI:MGI:1859559
    See related
    Ensembl:ENSMUSG00000067144 AllianceGenome:MGI:1859559
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    NLT; OAT2
    Summary
    Enables organic anion transmembrane transporter activity. Acts upstream of or within response to stilbenoid. Predicted to be located in basolateral plasma membrane. Is expressed in metanephros. Orthologous to human SLC22A7 (solute carrier family 22 member 7). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Restricted expression toward kidney adult (RPKM 85.4) See more
    Orthologs
    human all
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    Genomic context

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    Location:
    17 C; 17 22.9 cM
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (46743111..46749403, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (46432185..46438477, complement)

    Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene zinc finger protein 318 Neighboring gene predicted gene 9706 Neighboring gene cysteine-rich protein 3 Neighboring gene predicted gene, 36541 Neighboring gene ribosomal protein L11 pseudogene Neighboring gene tau tubulin kinase 1 Neighboring gene STARR-seq mESC enhancer starr_42667

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Mouse organic anion transporter 2 (mOat2) mediates the transport of short chain fatty acid propionate. Islam R, et al. J Pharmacol Sci, 2008 Mar. PMID 18344607
    2. Isolation, characterization and differential gene expression of multispecific organic anion transporter 2 in mice. Kobayashi Y, et al. Mol Pharmacol, 2002 Jul. PMID 12065749
    3. Renal expression of organic anion transporter OAT2 in rats and mice is regulated by sex hormones. Ljubojević M, et al. Am J Physiol Renal Physiol, 2007 Jan. PMID 16885152
    4. Mouse organic anion transporter 2 and 3 (mOAT2/3[Slc22a7/8]) mediates the renal transport of bumetanide. Kobayashi Y, et al. Eur J Pharmacol, 2005 Nov 7. PMID 16256982
    5. Epigenetic regulation of an IAP retrotransposon in the aging mouse: progressive demethylation and de-silencing of the element by its repetitive induction. Barbot W, et al. Nucleic Acids Res, 2002 Jun 1. PMID 12034823, Free PMC Article

    See all (22) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. propionate (3-carbon SCFA) was transported by mOat2 in a time-dependent manner.
      Title: Mouse organic anion transporter 2 (mOat2) mediates the transport of short chain fatty acid propionate.
    2. there exists a sex- and species-related differential gene expression of the OAT2 isoform.
      Title: Isolation, characterization and differential gene expression of multispecific organic anion transporter 2 in mice.
    3. OAT2 in mouse kidney exhibiting gender differences (F > M) that appear in puberty and are caused by strong androgen inhibition and weak estrogen and progesterone stimulation
      Title: Renal expression of organic anion transporter OAT2 in rats and mice is regulated by sex hormones.
    4. Results indicate that mOAT2 plays a role for the transport of bumetanide on the luminal membranes of kidney proximal tubules.
      Title: Mouse organic anion transporter 2 and 3 (mOAT2/3[Slc22a7/8]) mediates the renal transport of bumetanide.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (3) 

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Clone Names

    • MGC18877

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables alpha-ketoglutarate transmembrane transporter activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables alpha-ketoglutarate transmembrane transporter activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables organic anion transmembrane transporter activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables organic anion transmembrane transporter activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables organic anion transmembrane transporter activity TAS
    Traceable Author Statement
    more info
    		 PubMed 
    enables prostaglandin transmembrane transporter activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables prostaglandin transmembrane transporter activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables sodium-independent organic anion transmembrane transporter activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables transmembrane transporter activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in alpha-ketoglutarate transport IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in alpha-ketoglutarate transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within monoatomic ion transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in organic anion transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within organic anion transport TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in prostaglandin transport IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in prostaglandin transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in response to stilbenoid IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in apical plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in apical plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in basal plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in basolateral plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in plasma membrane TAS
    Traceable Author Statement
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    solute carrier family 22 member 7
    Names
    mOAT2
    organic anion transporter 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_144856.2 → NP_659105.2  solute carrier family 22 member 7

      See identical proteins and their annotated locations for NP_659105.2

      Status: VALIDATED

      Source sequence(s)
      AK082865, AK143949
      Consensus CDS
      CCDS28829.1
      UniProtKB/Swiss-Prot
      Q3UNX2, Q8BUQ9, Q8K4S9, Q8R0M7, Q8R125, Q91WU2
      UniProtKB/TrEMBL
      A0A0R4J122
      Related
      ENSMUSP00000084234.6, ENSMUST00000087012.7
      Conserved Domains (2) summary
      cd06174
      Location:146 → 511
      MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...
      TIGR00898
      Location:11 → 521
      2A0119; cation transport protein

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000083.7 Reference GRCm39 C57BL/6J

      Range
      46743111..46749403 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q91WU2.1 GenPept UniProtKB/Swiss-Prot:Q91WU2

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Other Literature Sources
    Chemical Information
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