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    Psmg2 proteasome (prosome, macropain) assembly chaperone 2 [ Mus musculus (house mouse) ]

    Gene ID: 107047, updated on 5-Mar-2024

    Summary

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    Official Symbol
    Psmg2provided by MGI
    Official Full Name
    proteasome (prosome, macropain) assembly chaperone 2provided by MGI
    Primary source
    MGI:MGI:1922901
    See related
    Ensembl:ENSMUSG00000024537 AllianceGenome:MGI:1922901
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Clast3; Tnfsf5ip1; 1700017I17Rik
    Summary
    Predicted to enable molecular adaptor activity. Acts upstream of or within mitotic spindle assembly checkpoint signaling and negative regulation of apoptotic process. Located in nucleus. Orthologous to human PSMG2 (proteasome assembly chaperone 2). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in liver E14 (RPKM 23.8), CNS E11.5 (RPKM 21.8) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    18 E1; 18 40.05 cM
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 18 NC_000084.7 (67774657..67787251)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 18 NC_000084.6 (67641587..67654181)

    Chromosome 18 - NC_000084.7Genomic Context describing neighboring genes Neighboring gene spire type actin nucleation factor 1 Neighboring gene STARR-seq mESC enhancer starr_44907 Neighboring gene predicted gene, 17669 Neighboring gene STARR-positive B cell enhancer mm9_chr18:67771962-67772263 Neighboring gene centrosomal protein 76 Neighboring gene protein tyrosine phosphatase, non-receptor type 2 Neighboring gene STARR-positive B cell enhancer ABC_E11000 Neighboring gene STARR-positive B cell enhancer ABC_E8723 Neighboring gene STARR-seq mESC enhancer starr_44912 Neighboring gene predicted gene, 46626

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Growth retardation, polyploidy, and multinucleation induced by Clast3, a novel cell cycle-regulated protein. Bahar R, et al. J Biol Chem, 2002 Oct 18. PMID 12147697
    2. PAC1 gene knockout reveals an essential role of chaperone-mediated 20S proteasome biogenesis and latent 20S proteasomes in cellular homeostasis. Sasaki K, et al. Mol Cell Biol, 2010 Aug. PMID 20498273, Free PMC Article
    3. Congenital asplenia in mice and humans with mutations in a Pbx/Nkx2-5/p15 module. Koss M, et al. Dev Cell, 2012 May 15. PMID 22560297, Free PMC Article
    4. The TRIM9/TRIM67 neuronal interactome reveals novel activators of morphogenesis. Menon S, et al. Mol Biol Cell, 2021 Feb 15. PMID 33378226, Free PMC Article
    5. An Interaction Landscape of Ubiquitin Signaling. Zhang X, et al. Mol Cell, 2017 Mar 2. PMID 28190767

    See all (22) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables molecular adaptor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in chaperone-mediated protein complex assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within mitotic spindle assembly checkpoint signaling IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within negative regulation of apoptotic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in proteasome assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within regulation of cell cycle IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of protein folding chaperone complex ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    proteasome assembly chaperone 2
    Names
    CD40 ligand-activated specific transcript 3
    tumor necrosis factor superfamily, member 5-induced protein 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001368147.1 → NP_001355076.1  proteasome assembly chaperone 2 isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (2) is shorter at the N-terminus compared to isoform 1.
      Source sequence(s)
      AC108434, AC120410
      Consensus CDS
      CCDS89268.1
      Related
      ENSMUSP00000157785.2, ENSMUST00000235799.2

    2. NM_134138.2 → NP_598899.1  proteasome assembly chaperone 2 isoform 1

      See identical proteins and their annotated locations for NP_598899.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longer isoform (1).
      Source sequence(s)
      AK077569, AW123048, BY012642
      Consensus CDS
      CCDS29324.1
      UniProtKB/Swiss-Prot
      Q3TII5, Q3UXH7, Q8C1R5, Q91YJ0, Q9EST4
      Related
      ENSMUSP00000025418.4, ENSMUST00000025418.4
      Conserved Domains (1) summary
      pfam09754
      Location:17 → 126
      PAC2; PAC2 family

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000084.7 Reference GRCm39 C57BL/6J

      Range
      67774657..67787251
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9EST4.1 GenPept UniProtKB/Swiss-Prot:Q9EST4

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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