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    TJP3 tight junction protein 3 [ Sus scrofa (pig) ]

    Gene ID: 100626455, updated on 8-Mar-2024

    Summary

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    Official Symbol
    TJP3provided by VGNC
    Official Full Name
    tight junction protein 3provided by VGNC
    Primary source
    VGNC:VGNC:94006
    See related
    Ensembl:ENSSSCG00000013491
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Sus scrofa
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Suina; Suidae; Sus
    Expression
    Biased expression in lung (RPKM 4.3), kidney (RPKM 2.0) and 3 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    Location:
    chromosome: 2
    Exon count:
    22
    Annotation release Status Assembly Chr Location
    106 current Sscrofa11.1 (GCF_000003025.6) 2 NC_010444.4 (74938153..74971431, complement)
    105 previous assembly Sscrofa10.2 (GCF_000003025.5) 2 NC_010444.3 (75529624..75562870, complement)

    Chromosome 2 - NC_010444.4Genomic Context describing neighboring genes Neighboring gene megakaryocyte-associated tyrosine kinase Neighboring gene mitochondrial ribosomal protein L54 Neighboring gene retina and anterior neural fold homeobox 2 Neighboring gene amyloid beta precursor protein binding family A member 3 Neighboring gene phosphatidylinositol-4-phosphate 5-kinase type 1 gamma Neighboring gene cactin, spliceosome C complex subunit

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Transcriptome data used for gene annotation
    • Description: Nine kinds of tissues and a mixture of multiple tissues were sequenced for genome annotation
    • BioProject: PRJNA311523
    • Publication: PMID 27646534
    • Analysis date: Thu Dec 14 17:10:49 2017

    Bibliography

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    Related articles in PubMed

    1. Exosomal miRNA-328-3p targets ZO-3 and inhibits porcine epidemic diarrhea virus proliferation. Zhao H, et al. Arch Virol, 2022 Mar. PMID 35147806

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Exosomal miRNA-328-3p targets ZO-3 and inhibits porcine epidemic diarrhea virus proliferation.
      Title: Exosomal miRNA-328-3p targets ZO-3 and inhibits porcine epidemic diarrhea virus proliferation.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables cell adhesion molecule binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in cell-cell adhesion IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in cell-cell junction organization IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in establishment of endothelial intestinal barrier IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in positive regulation of blood-brain barrier permeability IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in protein localization to cell-cell junction IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in bicellular tight junction IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    tight junction protein ZO-3
    Names
    tight junction protein 3 (zona occludens 3)

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: Sus scrofa Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference Sscrofa11.1 Primary Assembly

    Genomic

    1. NC_010444.4 Reference Sscrofa11.1 Primary Assembly

      Range
      74938153..74971431 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005661351.3 → XP_005661408.1  tight junction protein ZO-3 isoform X1

      UniProtKB/TrEMBL
      A0A8D1B914, A0A8D1F949
      Related
      ENSSSCP00000040763.2, ENSSSCT00000056554.3
      Conserved Domains (4) summary
      smart00072
      Location:582 → 758
      GuKc; Guanylate kinase homologues
      cd00992
      Location:375 → 454
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      pfam00625
      Location:613 → 757
      Guanylate_kin; Guanylate kinase
      cl17036
      Location:470 → 540
      SH3; Src Homology 3 domain superfamily

    2. XM_013994777.2 → XP_013850231.1  tight junction protein ZO-3 isoform X2

      UniProtKB/TrEMBL
      A0A480E3X0, A0A8D0KLP7
      Conserved Domains (4) summary
      smart00072
      Location:591 → 767
      GuKc; Guanylate kinase homologues
      cd00992
      Location:384 → 463
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      pfam00625
      Location:622 → 766
      Guanylate_kin; Guanylate kinase
      cl17036
      Location:479 → 549
      SH3; Src Homology 3 domain superfamily

    3. XM_005661349.3 → XP_005661406.1  tight junction protein ZO-3 isoform X3

      UniProtKB/TrEMBL
      A0A8D0KLP7
      Related
      ENSSSCP00000014339.5, ENSSSCT00000014737.5
      Conserved Domains (4) summary
      smart00072
      Location:587 → 763
      GuKc; Guanylate kinase homologues
      cd00992
      Location:380 → 459
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      pfam00625
      Location:618 → 762
      Guanylate_kin; Guanylate kinase
      cl17036
      Location:475 → 545
      SH3; Src Homology 3 domain superfamily
    Nucleotide Protein
    Heading Accession and Version

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