HACE1 HECT domain and ankyrin repeat containing E3 ubiquitin protein ligase 1 [Ailuropoda melanoleuca (giant panda)] - Gene

Summary

Gene symbol: HACE1
Gene description: HECT domain and ankyrin repeat containing E3 ubiquitin protein ligase 1
Locus tag: PANDA_005263
See related: Ensembl:ENSAMEG00000011456
Gene type: protein coding
RefSeq status: MODEL
Organism: Ailuropoda melanoleuca
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Ursidae; Ailuropoda
Orthologs: human mouse all
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Annotation release	Status	Assembly	Chr	Location
103	current	ASM200744v2 (GCF_002007445.1)	10	NC_048227.1 (55080521..55184461, complement)
102	previous assembly	AilMel_1.0 (GCF_000004335.2)	Unplaced Scaffold	NW_003217461.1 (754210..855290)

Chromosome 10 - NC_048227.1 Genomic Context describing neighboring genes

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Submit: New GeneRIF Correction

Function	Evidence Code	Pubs
enables protein binding	IEA Inferred from Electronic Annotation more info	PubMed
enables ubiquitin-protein transferase activity	IEA Inferred from Electronic Annotation more info	PubMed

Process	Evidence Code	Pubs
involved_in positive regulation of protein catabolic process	IEA Inferred from Electronic Annotation more info	PubMed
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process	IEA Inferred from Electronic Annotation more info	PubMed
involved_in protein polyubiquitination	IEA Inferred from Electronic Annotation more info	PubMed

Component	Evidence Code	Pubs
located_in nucleus	IEA Inferred from Electronic Annotation more info	PubMed

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The following sections contain reference sequences that belong to a specific genome build. Explain

XM_019797279.2 → XP_019652838.1 E3 ubiquitin-protein ligase HACE1 isoform X2

UniProtKB/TrEMBL

D2H5S3
XM_002917046.4 → XP_002917092.1 E3 ubiquitin-protein ligase HACE1 isoform X1

UniProtKB/TrEMBL

D2H5S3, G1LYF1

Related

ENSAMEP00000012107.2, ENSAMET00000012624.2

Conserved Domains (7) summary

smart00248
Location:66 → 93

ANK; ankyrin repeats

smart00119
Location:579 → 902

HECTc; Domain Homologous to E6-AP Carboxyl Terminus with

cd00078
Location:554 → 903

HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...

cd00204
Location:92 → 217

ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...

pfam12796
Location:69 → 194

Ank_2; Ankyrin repeats (3 copies)

pfam13637
Location:199 → 249

Ank_4; Ankyrin repeats (many copies)

sd00045
Location:97 → 128

ANK; ANK repeat [structural motif]
XM_019797280.2 → XP_019652839.1 E3 ubiquitin-protein ligase HACE1 isoform X3