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    AGO2 argonaute RISC catalytic component 2 [ Ailuropoda melanoleuca (giant panda) ]

    Gene ID: 100464244, updated on 8-Mar-2024

    Summary

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    Gene symbol
    AGO2
    Gene description
    argonaute RISC catalytic component 2
    Locus tag
    PANDA_009461
    See related
    Ensembl:ENSAMEG00000005019
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Ailuropoda melanoleuca
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Ursidae; Ailuropoda
    Also known as
    EIF2C2
    Orthologs
    human mouse all
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    Genomic context

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    Location:
    chromosome: 9
    Exon count:
    20
    Annotation release Status Assembly Chr Location
    103 current ASM200744v2 (GCF_002007445.1) 9 NC_048226.1 (100579897..100678545, complement)
    102 previous assembly AilMel_1.0 (GCF_000004335.2) Unplaced Scaffold NW_003217720.1 (1151065..1238546, complement)

    Chromosome 9 - NC_048226.1Genomic Context describing neighboring genes Neighboring gene potassium two pore domain channel subfamily K member 9 Neighboring gene trafficking protein particle complex subunit 9 Neighboring gene tropomyosin alpha-3 chain-like Neighboring gene chromatin accessibility complex subunit 1 Neighboring gene U12 minor spliceosomal RNA Neighboring gene protein tyrosine kinase 2 Neighboring gene DENN domain containing 3

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The sequence and de novo assembly of the giant panda genome. Li R, et al. Nature, 2010 Jan 21. PMID 20010809, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables RNA binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables endoribonuclease activity, cleaving siRNA-paired mRNA IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables protein binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in regulation of DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in regulatory ncRNA-mediated gene silencing IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of RISC complex IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    protein argonaute-2
    Names
    argonaute 2, RISC catalytic component
    eukaryotic translation initiation factor 2C, 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: Ailuropoda melanoleuca Annotation Release 103 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ASM200744v2 Primary Assembly

    Genomic

    1. NC_048226.1 Reference ASM200744v2 Primary Assembly

      Range
      100579897..100678545 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_019801181.2 → XP_019656740.1  protein argonaute-2 isoform X3

      UniProtKB/TrEMBL
      D2HF39

    2. XM_019801180.2 → XP_019656739.1  protein argonaute-2 isoform X1

      UniProtKB/TrEMBL
      D2HF39

    3. XM_011226774.3 → XP_011225076.1  protein argonaute-2 isoform X2

      UniProtKB/TrEMBL
      G1LEP7
      Related
      ENSAMEP00000005384.2, ENSAMET00000005606.2
      Conserved Domains (5) summary
      PLN03202
      Location:83 → 893
      PLN03202; protein argonaute; Provisional
      cd02846
      Location:285 → 405
      PAZ_argonaute_like; PAZ domain, argonaute_like subfamily. Argonaute is part of the RNA-induced silencing complex (RISC), and is an endonuclease that plays a key role in the RNA interference pathway. The PAZ domain has been named after the proteins Piwi,Argonaut, and Zwille. ...
      cd04657
      Location:450 → 852
      Piwi_ago-like; Piwi_ago-like: PIWI domain, Argonaute-like subfamily. Argonaute is the central component of the RNA-induced silencing complex (RISC) and related complexes. The PIWI domain is the C-terminal portion of Argonaute and consists of two subdomains, one of ...
      pfam08699
      Location:235 → 284
      ArgoL1; Argonaute linker 1 domain
      pfam16486
      Location:86 → 224
      ArgoN; N-terminal domain of argonaute
    Nucleotide Protein
    Heading Accession and Version

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