Kirrel2 kirre like nephrin family adhesion molecule 2 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Kirrel2provided by RGD
Official Full Name: kirre like nephrin family adhesion molecule 2provided by RGD
Primary source: RGD:1308456
See related: Ensembl:ENSRNOG00000020864 AllianceGenome:RGD:1308456
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable cell adhesion molecule binding activity and identical protein binding activity. Predicted to be involved in cell-cell adhesion. Predicted to act upstream of or within negative regulation of protein phosphorylation. Predicted to be located in plasma membrane and slit diaphragm. Predicted to be active in cell-cell junction. Predicted to be integral component of plasma membrane. Orthologous to human KIRREL2 (kirre like nephrin family adhesion molecule 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Brain (RPKM 3.3), Kidney (RPKM 2.8) and 8 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 1q21

Exon count:: 15

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	1	NC_086019.1 (94836243..94846119, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	1	NC_051336.1 (85708793..85718670, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	1	NC_005100.4 (88909829..88921154, complement)

Chromosome 1 - NC_086019.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables cell adhesion molecule binding	IBA Inferred from Biological aspect of Ancestor more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in cell-cell adhesion	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within cell-cell adhesion	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of protein phosphorylation	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in cell-cell junction	IBA Inferred from Biological aspect of Ancestor more info
located_in cell-cell junction	ISO Inferred from Sequence Orthology more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in slit diaphragm	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: kin of IRRE-like protein 2

Names: kin of IRRE like 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001271398.1 → NP_001258327.1 kin of IRRE-like protein 2 precursor

See identical proteins and their annotated locations for NP_001258327.1

Status: PROVISIONAL

Source sequence(s)

JAXUCZ010000001

UniProtKB/TrEMBL

A0A8I6AAI0, D4A934

Related

ENSRNOP00000028306.5, ENSRNOT00000028306.7

Conserved Domains (4) summary

smart00410
Location:27 → 116

IG_like; Immunoglobulin like

pfam07679
Location:314 → 392

I-set; Immunoglobulin I-set domain

pfam13927
Location:227 → 292

Ig_3; Immunoglobulin domain

cl11960
Location:394 → 498

Ig; Immunoglobulin domain