TNFRSF12A TNF receptor superfamily member 12A [Sus scrofa (pig)] - Gene

Summary

Official Symbol: TNFRSF12Aprovided by VGNC
Official Full Name: TNF receptor superfamily member 12Aprovided by VGNC
Primary source: VGNC:VGNC:94258
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Sus scrofa
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Suina; Suidae; Sus
Also known as: Fn14; TWEAKR
Expression: Broad expression in longissimus dorsi muscle (RPKM 71.3), heart (RPKM 67.6) and 7 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 3

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
106	current	Sscrofa11.1 (GCF_000003025.6)	3	NC_010445.4 (39166288..39168294, complement)
105	previous assembly	Sscrofa10.2 (GCF_000003025.5)	3	NC_010445.3 (40531414..40533682)

Chromosome 3 - NC_010445.4 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Transcriptome data used for gene annotation
Description: Nine kinds of tissues and a mixture of multiple tissues were sequenced for genome annotation
BioProject: PRJNA311523
Publication: PMID 27646534
Analysis date: Thu Dec 14 17:10:49 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The TWEAK-independent Fn14 activation augments TLR4-mediated inflammatory responses in the intestine of piglets.
Title: Lipopolysaccharide Upregulated Intestinal Epithelial Cell Expression of Fn14 and Activation of Fn14 Signaling Amplify Intestinal TLR4-Mediated Inflammation.

Submit: New GeneRIF Correction

General gene information

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Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables protein binding	IEA Inferred from Electronic Annotation more info	PubMed

Process	Evidence Code	Pubs
involved_in positive regulation of apoptotic process	IEA Inferred from Electronic Annotation more info	PubMed

Component	Evidence Code	Pubs
located_in plasma membrane	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

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Preferred Names: tumor necrosis factor receptor superfamily member 12A

Names: fibroblast growth factor-inducible 14

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001142839.2 → NP_001136311.1 tumor necrosis factor receptor superfamily member 12A precursor

See identical proteins and their annotated locations for NP_001136311.1

Status: VALIDATED

Source sequence(s)

AEMK02000018, EW508106

UniProtKB/TrEMBL

B7SLY2

Conserved Domains (2) summary

cd13413
Location:36 → 104

TNFRSF12A; CRD2 [structural motif]

pfam12191
Location:23 → 129

stn_TNFRSF12A; Tumour necrosis factor receptor stn_TNFRSF12A_TNFR domain