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    PRKACB protein kinase cAMP-activated catalytic subunit beta [ Pongo abelii (Sumatran orangutan) ]

    Gene ID: 100174748, updated on 3-Apr-2024

    Summary

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    Gene symbol
    PRKACB
    Gene description
    protein kinase cAMP-activated catalytic subunit beta
    Locus tag
    CR201_G0008742
    See related
    Ensembl:ENSPPYG00000001209
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Pongo abelii
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Pongo
    Orthologs
    human mouse all
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    Genomic context

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    Location:
    chromosome: 1
    Exon count:
    16
    Annotation release Status Assembly Chr Location
    RS_2024_02 current NHGRI_mPonAbe1-v2.0_pri (GCF_028885655.2) 1 NC_071985.2 (148759017..148915987, complement)
    RS_2023_04 previous assembly NHGRI_mPonAbe1-v1.1-hic.freeze_pri (GCF_028885655.1) 1 NC_071985.1 (148765925..148922805, complement)

    Chromosome 1 - NC_071985.2Genomic Context describing neighboring genes Neighboring gene small nucleolar RNA SNORA2/SNORA34 family Neighboring gene NEDD8-like Neighboring gene small nucleolar RNA U3 Neighboring gene thioredoxin, mitochondrial Neighboring gene tubulin tyrosine ligase like 7 Neighboring gene uncharacterized LOC129050425

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Clone Names

    • DKFZp459E242, DKFZp469I061, DKFZp459O1932

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables protein serine/threonine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in protein kinase A signaling IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in protein phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    cAMP-dependent protein kinase catalytic subunit beta
    Names
    protein kinase, cAMP-dependent, catalytic, beta
    NP_001127665.1
    NP_001128782.1
    XP_009246811.1
    XP_009246817.1
    XP_054403557.1
    XP_054403567.1
    XP_054403568.1
    XP_054403572.1
    XP_054403573.1
    XP_054403576.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001134193.1 → NP_001127665.1  cAMP-dependent protein kinase catalytic subunit beta isoform 2

      See identical proteins and their annotated locations for NP_001127665.1

      Status: PROVISIONAL

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR and has multiple 5' coding region differences, compared to variant 1. These differences result in translation initiation from a distinct ATG codon and a protein (isoform 2) with a distinct N-terminus, compared to isoform 1.
      Source sequence(s)
      CR861386
      UniProtKB/TrEMBL
      Q5R472, Q5RC73
      Related
      ENSPPYP00000025744.1, ENSPPYT00000040098.1
      Conserved Domains (1) summary
      cd14209
      Location:45 → 334
      STKc_PKA; Catalytic subunit of the Serine/Threonine Kinase, cAMP-dependent protein kinase

    2. NM_001135310.1 → NP_001128782.1  cAMP-dependent protein kinase catalytic subunit beta isoform 1

      See identical proteins and their annotated locations for NP_001128782.1

      Status: PROVISIONAL

      Description
      Transcript Variant: This variant (1) encodes the longer isoform (1).
      Source sequence(s)
      CR859243
      UniProtKB/TrEMBL
      Q5R9Y7, Q5RC73
      Related
      ENSPPYP00000033134.1, ENSPPYT00000060573.1
      Conserved Domains (2) summary
      PTZ00263
      Location:88 → 397
      PTZ00263; protein kinase A catalytic subunit; Provisional
      cd14209
      Location:89 → 378
      STKc_PKA; Catalytic subunit of the Serine/Threonine Kinase, cAMP-dependent protein kinase

    RefSeqs of Annotated Genomes: GCF_028885655.2-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference NHGRI_mPonAbe1-v2.0_pri Primary Assembly

    Genomic

    1. NC_071985.2 Reference NHGRI_mPonAbe1-v2.0_pri Primary Assembly

      Range
      148759017..148915987 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_009248536.4 → XP_009246811.1  cAMP-dependent protein kinase catalytic subunit beta isoform X2

      See identical proteins and their annotated locations for XP_009246811.1

      UniProtKB/TrEMBL
      A0A2J8WQD2, A0A8I5TE79, Q5RC73
      Related
      ENSPPYP00000035196.1
      Conserved Domains (1) summary
      cd14209
      Location:42 → 331
      STKc_PKA; Catalytic subunit of the Serine/Threonine Kinase, cAMP-dependent protein kinase

    2. XM_009248542.3 → XP_009246817.1  cAMP-dependent protein kinase catalytic subunit beta isoform X3

      See identical proteins and their annotated locations for XP_009246817.1

      UniProtKB/TrEMBL
      A0A2J8WQD9, A0A8I5U9M6, A0A8I5YMR3
      Related
      ENSPPYP00000039345.1
      Conserved Domains (1) summary
      cd14209
      Location:30 → 319
      STKc_PKA; Catalytic subunit of the Serine/Threonine Kinase, cAMP-dependent protein kinase

    3. XM_054547582.1 → XP_054403557.1  cAMP-dependent protein kinase catalytic subunit beta isoform X1

      UniProtKB/TrEMBL
      A0A2J8WQG4, A0A8I5YQH4

    4. XM_054547598.2 → XP_054403573.1  cAMP-dependent protein kinase catalytic subunit beta isoform X7

    5. XM_054547592.2 → XP_054403567.1  cAMP-dependent protein kinase catalytic subunit beta isoform X4

    6. XM_054547601.2 → XP_054403576.1  cAMP-dependent protein kinase catalytic subunit beta isoform X8

    7. XM_054547593.2 → XP_054403568.1  cAMP-dependent protein kinase catalytic subunit beta isoform X5

    8. XM_054547597.2 → XP_054403572.1  cAMP-dependent protein kinase catalytic subunit beta isoform X6

    Nucleotide Protein
    Heading Accession and Version

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