SPARC secreted protein acidic and cysteine rich [Pongo abelii (Sumatran orangutan)] - Gene

Summary

Gene symbol: SPARC
Gene description: secreted protein acidic and cysteine rich
Locus tag: CR201_G0004551
See related: Ensembl:ENSPPYG00000030691
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Pongo abelii
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Pongo
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 4

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	NHGRI_mPonAbe1-v2.0_pri (GCF_028885655.2)	4	NC_071989.2 (160341653..160366408, complement)
RS_2023_04	previous assembly	NHGRI_mPonAbe1-v1.1-hic.freeze_pri (GCF_028885655.1)	5	NC_071990.1 (160176757..160201280, complement)

Chromosome 4 - NC_071989.2 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Markers

SHGC-84435 (e-PCR)
- UniSTS:104737

RH68620 (e-PCR)
- UniSTS:52073

234 (e-PCR), detects polymorphism
- UniSTS:34189

GDB:201800 (e-PCR)
- UniSTS:156061

RH71413 (e-PCR)
- UniSTS:75456

RH65614 (e-PCR)
- UniSTS:53202

RH47515 (e-PCR)
- UniSTS:89827

SPARC_1369 (e-PCR)
- UniSTS:462567

GDB:294200 (e-PCR)
- UniSTS:156392

D5S444E (e-PCR)
- UniSTS:6399

Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables calcium ion binding	IEA Inferred from Electronic Annotation more info	PubMed
enables collagen binding	IEA Inferred from Electronic Annotation more info	PubMed
enables extracellular matrix binding	IEA Inferred from Electronic Annotation more info	PubMed
enables protein binding	IEA Inferred from Electronic Annotation more info	PubMed

Process	Evidence Code	Pubs
involved_in anatomical structure development	IEA Inferred from Electronic Annotation more info	PubMed

Component	Evidence Code	Pubs
located_in extracellular space	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

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Preferred Names: SPARC

Names: ON; osteonectin; secreted protein acidic and rich in cysteine; secreted protein, acidic, cysteine-rich (osteonectin)

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001133570.1 → NP_001127042.1 SPARC precursor

See identical proteins and their annotated locations for NP_001127042.1

Status: PROVISIONAL

Source sequence(s)

CR861427

UniProtKB/TrEMBL

A0A8I5T153

Related

ENSPPYP00000032437.1, ENSPPYT00000057620.1

Conserved Domains (3) summary

cd00252
Location:154 → 301

SPARC_EC; SPARC_EC; extracellular Ca2+ binding domain (containing 2 EF-hand motifs) of SPARC and related proteins (QR1, SC1/hevin, testican and tsc-36/FRP). SPARC (BM-40) is a multifunctional glycoprotein, a matricellular protein, that functions to regulate ...

cd01328
Location:71 → 152

FSL_SPARC; Follistatin-like SPARC (secreted protein, acidic, and rich in cysteines) domain; SPARC/BM-40/osteonectin is a multifunctional glycoprotein which modulates cellular interaction with the extracellular matrix by its binding to structural matrix proteins ...

pfam10591
Location:153 → 287

SPARC_Ca_bdg; Secreted protein acidic and rich in cysteine Ca binding region

RefSeqs of Annotated Genomes: GCF_028885655.2-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference NHGRI_mPonAbe1-v2.0_pri Primary Assembly

Genomic

NC_071989.2 Reference NHGRI_mPonAbe1-v2.0_pri Primary Assembly

Range

160341653..160366408 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_063723944.1 → XP_063580014.1 SPARC isoform X1
XM_024246770.3 → XP_024102538.1 SPARC isoform X2

UniProtKB/TrEMBL

A0A8I5T153

Conserved Domains (2) summary

cd01328
Location:70 → 151

FSL_SPARC; Follistatin-like SPARC (secreted protein, acidic, and rich in cysteines) domain; SPARC/BM-40/osteonectin is a multifunctional glycoprotein which modulates cellular interaction with the extracellular matrix by its binding to structural matrix proteins ...

cd16231
Location:154 → 293

EFh_SPARC_like; EF-hand, extracellular calcium-binding (EC) motif, found in secreted protein acidic and rich in cysteine (SPARC) and similar proteins