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    GABRA2 gamma-aminobutyric acid type A receptor subunit alpha2 [ Pongo abelii (Sumatran orangutan) ]

    Gene ID: 100173835, updated on 26-Mar-2024

    Summary

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    Gene symbol
    GABRA2
    Gene description
    gamma-aminobutyric acid type A receptor subunit alpha2
    Locus tag
    CR201_G0034629
    See related
    Ensembl:ENSPPYG00000014705
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Pongo abelii
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Pongo
    Annotation information
    Annotation category: partial on reference assembly
    Orthologs
    human mouse all
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    Genomic context

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    Location:
    chromosome: 3
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_02 current NHGRI_mPonAbe1-v2.0_pri (GCF_028885655.2) 3 NC_071988.2 (45723828..45964622, complement)
    RS_2023_04 previous assembly NHGRI_mPonAbe1-v1.1-hic.freeze_pri (GCF_028885655.1) 4 NC_071989.1 (45747752..45992791, complement)

    Chromosome 3 - NC_071988.2Genomic Context describing neighboring genes Neighboring gene transcription factor NF-E4-like Neighboring gene gamma-aminobutyric acid type A receptor subunit gamma1 Neighboring gene uncharacterized LOC129059153 Neighboring gene U6 spliceosomal RNA Neighboring gene cytochrome c oxidase subunit 7B2, mitochondrial

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Clone Names

    • DKFZp459J146, DKFZp459N0431

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables GABA-A receptor activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables GABA-gated chloride ion channel activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables benzodiazepine receptor activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables inhibitory extracellular ligand-gated monoatomic ion channel activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in chloride transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in gamma-aminobutyric acid signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in nervous system process IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in regulation of postsynaptic membrane potential IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in synaptic transmission, GABAergic IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of GABA-A receptor complex IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in dendrite membrane IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in neuron projection IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in postsynapse IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in synapse IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    gamma-aminobutyric acid receptor subunit alpha-2
    Names
    GABA(A) receptor subunit alpha-2
    gamma-aminobutyric acid (GABA) A receptor, alpha 2
    gamma-aminobutyric acid type A receptor alpha2 subunit

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001133357.1 → NP_001126829.1  gamma-aminobutyric acid receptor subunit alpha-2 precursor

      See identical proteins and their annotated locations for NP_001126829.1

      Status: PROVISIONAL

      Source sequence(s)
      CR860987
      UniProtKB/TrEMBL
      A0A2J8TIS8, A0A8I5UDA6
      Related
      ENSPPYP00000016427.3, ENSPPYT00000017096.3
      Conserved Domains (3) summary
      TIGR00860
      Location:25 → 440
      LIC; Cation transporter family protein
      pfam02931
      Location:43 → 250
      Neur_chan_LBD; Neurotransmitter-gated ion-channel ligand binding domain
      pfam02932
      Location:257 → 437
      Neur_chan_memb; Neurotransmitter-gated ion-channel transmembrane region

    RefSeqs of Annotated Genomes: GCF_028885655.2-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference NHGRI_mPonAbe1-v2.0_pri Primary Assembly

    Genomic

    1. NC_071988.2 Reference NHGRI_mPonAbe1-v2.0_pri Primary Assembly

      Range
      45723828..45964622 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q5RCC5.2 GenPept UniProtKB/Swiss-Prot:Q5RCC5

    Gene LinkOut

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