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    myd88 MYD88 innate immune signal transduction adaptor [ Salmo salar (Atlantic salmon) ]

    Gene ID: 100169859, updated on 8-Mar-2024

    Summary

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    Gene symbol
    myd88
    Gene description
    MYD88 innate immune signal transduction adaptor
    See related
    Ensembl:ENSSSAG00000067007
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Salmo salar
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Protacanthopterygii; Salmoniformes; Salmonidae; Salmoninae; Salmo
    Orthologs
    human zebrafish all
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    Genomic context

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    See myd88 in Genome Data Viewer
    Location:
    chromosome: ssa29
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    102 current Ssal_v3.1 (GCF_905237065.1) ssa29 NC_059470.1 (41557784..41576332, complement)
    100 previous assembly ICSASG_v2 (GCF_000233375.1) ssa29 NC_027328.1 (41256314..41268193)

    Chromosome ssa29 - NC_059470.1Genomic Context describing neighboring genes Neighboring gene cysteine-serine-rich nuclear protein 1b Neighboring gene uncharacterized LOC123731540 Neighboring gene uncharacterized LOC106590690 Neighboring gene mitogen-activated protein kinase kinase kinase 22 Neighboring gene 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Double-stranded RNA- and CpG DNA-induced immune responses in Atlantic salmon: comparison and synergies. Strandskog G, et al. Vaccine, 2008 Aug 26. PMID 18602433
    2. Identification and characterization of TLR8 and MyD88 homologs in Atlantic salmon (Salmo salar). Skjaeveland I, et al. Dev Comp Immunol, 2009 Sep. PMID 19422846
    3. MyD88 interacts with interferon regulatory factor (IRF) 3 and IRF7 in Atlantic salmon (Salmo salar): transgenic SsMyD88 modulates the IRF-induced type I interferon response and accumulates in aggresomes. Iliev DB, et al. J Biol Chem, 2011 Dec 9. PMID 21990356, Free PMC Article

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. MyD88 interacts with interferon regulatory factor (IRF) 3 and IRF7 in Atlantic salmon (Salmo salar)
      Title: MyD88 interacts with interferon regulatory factor (IRF) 3 and IRF7 in Atlantic salmon (Salmo salar): transgenic SsMyD88 modulates the IRF-induced type I interferon response and accumulates in aggresomes.
    2. the salmon MyD88 was cloned and its expression was analysed.
      Title: Identification and characterization of TLR8 and MyD88 homologs in Atlantic salmon (Salmo salar).
    Submit: New GeneRIF Correction

    General gene information

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    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables TIR domain binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables Toll-like receptor binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in MyD88-dependent toll-like receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in Toll signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in defense response to Gram-positive bacterium IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in innate immune response IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in positive regulation of canonical NF-kappaB signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    myeloid differentiation primary response protein MyD88
    Names
    myeloid differentiation factor 88
    myeloid differentiation primary response 88
    myeloid differentiation primary response gene (88)

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001136545.1 → NP_001130017.1  myeloid differentiation primary response protein MyD88

      See identical proteins and their annotated locations for NP_001130017.1

      Status: PROVISIONAL

      Source sequence(s)
      EF672332
      UniProtKB/Swiss-Prot
      B3SRQ2
      UniProtKB/TrEMBL
      A0A1S2WZ01
      Related
      ENSSSAP00000080060.2, ENSSSAT00000113719.2
      Conserved Domains (2) summary
      smart00255
      Location:148 → 283
      TIR; Toll - interleukin 1 - resistance
      cd08312
      Location:19 → 97
      Death_MyD88; Death domain of Myeloid Differentation primary response protein MyD88

    RefSeqs of Annotated Genomes: Salmo salar Annotation Release 102 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference Ssal_v3.1

    Genomic

    1. NC_059470.1 Reference Ssal_v3.1

      Range
      41557784..41576332 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_045710471.1 → XP_045566427.1  myeloid differentiation primary response protein MyD88 isoform X1

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    B3SRQ2.1 GenPept UniProtKB/Swiss-Prot:B3SRQ2

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.