cdh2 cadherin 2 [Xenopus tropicalis (tropical clawed frog)] - Gene

Summary

Official Symbol: cdh2provided by Xenbase
Official Full Name: cadherin 2provided by Xenbase
Primary source: Xenbase:XB-GENE-951659
See related: Ensembl:ENSXETG00000006932
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Xenopus tropicalis
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana
Also known as: cdhn; ncad; N-Cad; cdh2-a; cdh2-b; cdw325; N-cadherin; cadherin-2
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 6

Exon count:: 16

Annotation release	Status	Assembly	Chr	Location
104	current	UCB_Xtro_10.0 (GCF_000004195.4)	6	NC_030682.2 (110962337..111096799, complement)
103	previous assembly	Xenopus_tropicalis_v9.1 (GCF_000004195.3)	6	NC_030682.1 (96002276..96139027, complement)

Chromosome 6 - NC_030682.2 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Connexin 43 controls neural crest cell migration in vivo by directly regulating N-cadherin transcription.
Title: Gap junction protein Connexin-43 is a direct transcriptional regulator of N-cadherin in vivo.
N- and E-cadherin play primary roles in F-actin assembly in addition to roles in cell adhesion, and that this function is specific to individual cadherins
Title: N- and E-cadherins in Xenopus are specifically required in the neural and non-neural ectoderm, respectively, for F-actin assembly and morphogenetic movements.

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General gene information

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Gene Ontology Provided by Xenbase

Function	Evidence Code	Pubs
enables calcium ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within cell adhesion	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within cell-cell adhesion	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within homophilic cell adhesion via plasma membrane adhesion molecules	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in adherens junction	IEA Inferred from Electronic Annotation more info
located_in cell surface	IEA Inferred from Electronic Annotation more info
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
located_in sarcolemma	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: cadherin-2

Names: cadherin 2, type 1, N-cadherin (neuronal)

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001127418.1 → NP_001120890.1 cadherin-2 precursor

See identical proteins and their annotated locations for NP_001120890.1

Status: PROVISIONAL

Source sequence(s)

BC166196

UniProtKB/TrEMBL

A0A6I8RCM5, A0A6I8RLL0, B2GUA1

Related

ENSXETP00000082746.2, ENSXETT00000095267.2

Conserved Domains (5) summary

cd11304
Location:274 → 379

Cadherin_repeat; Cadherin tandem repeat domain

pfam00028
Location:611 → 702

Cadherin; Cadherin domain

pfam01049
Location:751 → 904

Cadherin_C; Cadherin cytoplasmic region

pfam08758
Location:34 → 126

Cadherin_pro; Cadherin prodomain like

cl28889
Location:164 → 264

CA_like; Cadherin repeat-like domain