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    polg2 polymerase (DNA directed), gamma 2, accessory subunit [ Danio rerio (zebrafish) ]

    Gene ID: 100150674, updated on 27-Mar-2024

    Summary

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    Official Symbol
    polg2provided by ZNC
    Official Full Name
    polymerase (DNA directed), gamma 2, accessory subunitprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-060810-116
    See related
    Ensembl:ENSDARG00000074933 AllianceGenome:ZFIN:ZDB-GENE-060810-116
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    im:7158733; si:ch211-157f15.3
    Summary
    Predicted to be involved in mitochondrial DNA replication. Predicted to act upstream of or within DNA repair and DNA replication. Predicted to be active in mitochondrion. Is expressed in retina. Human ortholog(s) of this gene implicated in autosomal dominant progressive external ophthalmoplegia with mitochondrial DNA deletions 4 and mitochondrial DNA depletion syndrome. Orthologous to human POLG2 (DNA polymerase gamma 2, accessory subunit). [provided by Alliance of Genome Resources, Apr 2022]
    Orthologs
    human mouse all
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    Genomic context

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    Location:
    chromosome: 6
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    106 current GRCz11 (GCF_000002035.6) 6 NC_007117.7 (23010361..23024450)
    105 previous assembly GRCz10 (GCF_000002035.5) 6 NC_007117.6 (17912434..17928114)

    Chromosome 6 - NC_007117.7Genomic Context describing neighboring genes Neighboring gene nucleolar protein 11 Neighboring gene transfer RNA arginine (anticodon CCG) Neighboring gene signal recognition particle 68 Neighboring gene envoplakin a

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Evolutionary growth of certain metabolic pathways involved in the functioning of GAD and INS genes in Type 1 Diabetes Mellitus: Their architecture and stability. Tagore S, et al. Comput Biol Med, 2015 Jun. PMID 25862998
    2. Phagosomal and mitochondrial alterations in RPE may contribute to KCNJ13 retinopathy. Toms M, et al. Sci Rep, 2019 Mar 7. PMID 30846767, Free PMC Article
    3. Opa1 is required for proper mitochondrial metabolism in early development. Rahn JJ, et al. PLoS One, 2013. PMID 23516612, Free PMC Article
    4. The timing of Timezyme diversification in vertebrates. Cazaméa-Catalan D, et al. PLoS One, 2014. PMID 25486407, Free PMC Article
    5. Evolution of complexity in the zebrafish synapse proteome. Bayés À, et al. Nat Commun, 2017 Mar 2. PMID 28252024, Free PMC Article

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by ZFIN

    Process Evidence Code Pubs
    involved_in mitochondrial DNA replication IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    DNA polymerase subunit gamma-2, mitochondrial
    XP_001922359.2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007117.7 Reference GRCz11 Primary Assembly

      Range
      23010361..23024450
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_001922324.7 → XP_001922359.2  DNA polymerase subunit gamma-2, mitochondrial

      UniProtKB/TrEMBL
      A0A8M1QV74, E7F4P9
      Related
      ENSDARP00000099588.2, ENSDART00000113116.5
      Conserved Domains (3) summary
      PRK04173
      Location:40 → 436
      PRK04173; glycyl-tRNA synthetase; Provisional
      cl00266
      Location:320 → 438
      HGTP_anticodon; HGTP anticodon binding domain, as found at the C-terminus of histidyl, glycyl, threonyl and prolyl tRNA synthetases, which are classified as a group of class II aminoacyl-tRNA synthetases (aaRS). In aaRSs, the anticodon binding domain is responsible for ...
      cl00268
      Location:40 → 309
      class_II_aaRS-like_core; Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it attaches ...

    RNA

    1. XR_223753.4 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version

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