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    ARAP1 ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 1 [ Equus caballus (horse) ]

    Gene ID: 100052506, updated on 8-Mar-2024

    Summary

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    Official Symbol
    ARAP1provided by VGNC
    Official Full Name
    ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 1provided by VGNC
    Primary source
    VGNC:VGNC:15439
    See related
    Ensembl:ENSECAG00000016491
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Equus caballus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Perissodactyla; Equidae; Equus
    Also known as
    CENTD2
    Orthologs
    human mouse all
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    Genomic context

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    Location:
    chromosome: 7
    Exon count:
    39
    Annotation release Status Assembly Chr Location
    103 current EquCab3.0 (GCF_002863925.1) 7 NC_009150.3 (73132974..73194873)
    102 previous assembly EquCab2.0 (GCF_000002305.2) 7 NC_009150.2 (70968313..71017693)

    Chromosome 7 - NC_009150.3Genomic Context describing neighboring genes Neighboring gene autophagy related 16 like 2 Neighboring gene uncharacterized LOC111774342 Neighboring gene StAR related lipid transfer domain containing 10 Neighboring gene 40S ribosomal protein S12 pseudogene Neighboring gene phosphodiesterase 2A Neighboring gene microRNA mir-139 Neighboring gene uncharacterized LOC100629820

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Annotation of the Protein Coding Regions of the Equine Genome. Hestand MS, et al. PLoS One, 2015. PMID 26107351, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables GTPase activator activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables phosphatidylinositol-3,4,5-trisphosphate binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables protein binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in positive regulation of GTPase activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasmic vesicle IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in trans-Golgi network IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 1
    Names
    centaurin, delta 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: Equus caballus Annotation Release 103 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference EquCab3.0 Primary Assembly

    Genomic

    1. NC_009150.3 Reference EquCab3.0 Primary Assembly

      Range
      73132974..73194873
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_023645801.1 → XP_023501569.1  arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 1 isoform X1

      UniProtKB/TrEMBL
      F6WUK1
      Related
      ENSECAP00000014283.3, ENSECAT00000017568.3
      Conserved Domains (10) summary
      cd09490
      Location:6 → 68
      SAM_Arap1,2,3; SAM domain of Arap1,2,3 (angiotensin receptor-associated protein)
      cd04385
      Location:961 → 1139
      RhoGAP_ARAP; RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in ARAPs. ARAPs (also known as centaurin deltas) contain, besides the RhoGAP domain, an Arf GAP, ankyrin repeat ras-associating, and PH domains. Since their ArfGAP activity ...
      cd13253
      Location:333 → 425
      PH1_ARAP; ArfGAP with RhoGAP domain, ankyrin repeat and PH domain Pleckstrin homology (PH) domain, repeat 1
      cd13254
      Location:440 → 529
      PH2_ARAP; ArfGAP with RhoGAP domain, ankyrin repeat and PH domain Pleckstrin homology (PH) domain, repeat 2
      cd13256
      Location:747 → 852
      PH3_ARAP; ArfGAP with RhoGAP domain, ankyrin repeat and PH domain Pleckstrin homology (PH) domain, repeat 3
      cd13257
      Location:866 → 956
      PH4_ARAP; ArfGAP with RhoGAP domain, ankyrin repeat and PH domain Pleckstrin homology (PH) domain, repeat 4
      cd13259
      Location:1267 → 1406
      PH5_ARAP; ArfGAP with RhoGAP domain, ankyrin repeat and PH domain Pleckstrin homology (PH) domain, repeat 5
      pfam00788
      Location:1176 → 1264
      RA; Ras association (RalGDS/AF-6) domain
      pfam01412
      Location:539 → 655
      ArfGap; Putative GTPase activating protein for Arf
      cl25800
      Location:67 → 187
      GGN; Gametogenetin

    2. XM_023645803.1 → XP_023501571.1  arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 1 isoform X2

      UniProtKB/TrEMBL
      A0A3Q2HRV6, F6WUK1
      Related
      ENSECAP00000037850.1, ENSECAT00000053936.2
      Conserved Domains (10) summary
      cd09490
      Location:6 → 68
      SAM_Arap1,2,3; SAM domain of Arap1,2,3 (angiotensin receptor-associated protein)
      cd04385
      Location:961 → 1139
      RhoGAP_ARAP; RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in ARAPs. ARAPs (also known as centaurin deltas) contain, besides the RhoGAP domain, an Arf GAP, ankyrin repeat ras-associating, and PH domains. Since their ArfGAP activity ...
      cd13253
      Location:333 → 425
      PH1_ARAP; ArfGAP with RhoGAP domain, ankyrin repeat and PH domain Pleckstrin homology (PH) domain, repeat 1
      cd13254
      Location:440 → 529
      PH2_ARAP; ArfGAP with RhoGAP domain, ankyrin repeat and PH domain Pleckstrin homology (PH) domain, repeat 2
      cd13256
      Location:747 → 852
      PH3_ARAP; ArfGAP with RhoGAP domain, ankyrin repeat and PH domain Pleckstrin homology (PH) domain, repeat 3
      cd13257
      Location:866 → 956
      PH4_ARAP; ArfGAP with RhoGAP domain, ankyrin repeat and PH domain Pleckstrin homology (PH) domain, repeat 4
      cd13259
      Location:1267 → 1395
      PH5_ARAP; ArfGAP with RhoGAP domain, ankyrin repeat and PH domain Pleckstrin homology (PH) domain, repeat 5
      pfam00788
      Location:1176 → 1264
      RA; Ras association (RalGDS/AF-6) domain
      pfam01412
      Location:539 → 655
      ArfGap; Putative GTPase activating protein for Arf
      cl25800
      Location:67 → 187
      GGN; Gametogenetin

    3. XM_023645802.1 → XP_023501570.1  arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 1 isoform X1

      UniProtKB/TrEMBL
      F6WUK1
      Conserved Domains (10) summary
      cd09490
      Location:6 → 68
      SAM_Arap1,2,3; SAM domain of Arap1,2,3 (angiotensin receptor-associated protein)
      cd04385
      Location:961 → 1139
      RhoGAP_ARAP; RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in ARAPs. ARAPs (also known as centaurin deltas) contain, besides the RhoGAP domain, an Arf GAP, ankyrin repeat ras-associating, and PH domains. Since their ArfGAP activity ...
      cd13253
      Location:333 → 425
      PH1_ARAP; ArfGAP with RhoGAP domain, ankyrin repeat and PH domain Pleckstrin homology (PH) domain, repeat 1
      cd13254
      Location:440 → 529
      PH2_ARAP; ArfGAP with RhoGAP domain, ankyrin repeat and PH domain Pleckstrin homology (PH) domain, repeat 2
      cd13256
      Location:747 → 852
      PH3_ARAP; ArfGAP with RhoGAP domain, ankyrin repeat and PH domain Pleckstrin homology (PH) domain, repeat 3
      cd13257
      Location:866 → 956
      PH4_ARAP; ArfGAP with RhoGAP domain, ankyrin repeat and PH domain Pleckstrin homology (PH) domain, repeat 4
      cd13259
      Location:1267 → 1406
      PH5_ARAP; ArfGAP with RhoGAP domain, ankyrin repeat and PH domain Pleckstrin homology (PH) domain, repeat 5
      pfam00788
      Location:1176 → 1264
      RA; Ras association (RalGDS/AF-6) domain
      pfam01412
      Location:539 → 655
      ArfGap; Putative GTPase activating protein for Arf
      cl25800
      Location:67 → 187
      GGN; Gametogenetin

    4. XM_023645807.1 → XP_023501575.1  arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 1 isoform X3

      UniProtKB/TrEMBL
      A0A9L0RMQ9
      Conserved Domains (8) summary
      cd04385
      Location:716 → 894
      RhoGAP_ARAP; RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in ARAPs. ARAPs (also known as centaurin deltas) contain, besides the RhoGAP domain, an Arf GAP, ankyrin repeat ras-associating, and PH domains. Since their ArfGAP activity ...
      cd13253
      Location:88 → 180
      PH1_ARAP; ArfGAP with RhoGAP domain, ankyrin repeat and PH domain Pleckstrin homology (PH) domain, repeat 1
      cd13254
      Location:195 → 284
      PH2_ARAP; ArfGAP with RhoGAP domain, ankyrin repeat and PH domain Pleckstrin homology (PH) domain, repeat 2
      cd13256
      Location:502 → 607
      PH3_ARAP; ArfGAP with RhoGAP domain, ankyrin repeat and PH domain Pleckstrin homology (PH) domain, repeat 3
      cd13257
      Location:621 → 711
      PH4_ARAP; ArfGAP with RhoGAP domain, ankyrin repeat and PH domain Pleckstrin homology (PH) domain, repeat 4
      cd13259
      Location:1022 → 1161
      PH5_ARAP; ArfGAP with RhoGAP domain, ankyrin repeat and PH domain Pleckstrin homology (PH) domain, repeat 5
      pfam00788
      Location:931 → 1019
      RA; Ras association (RalGDS/AF-6) domain
      pfam01412
      Location:294 → 410
      ArfGap; Putative GTPase activating protein for Arf

    5. XM_023645804.1 → XP_023501572.1  arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 1 isoform X3

      UniProtKB/TrEMBL
      A0A9L0RMQ9
      Conserved Domains (8) summary
      cd04385
      Location:716 → 894
      RhoGAP_ARAP; RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in ARAPs. ARAPs (also known as centaurin deltas) contain, besides the RhoGAP domain, an Arf GAP, ankyrin repeat ras-associating, and PH domains. Since their ArfGAP activity ...
      cd13253
      Location:88 → 180
      PH1_ARAP; ArfGAP with RhoGAP domain, ankyrin repeat and PH domain Pleckstrin homology (PH) domain, repeat 1
      cd13254
      Location:195 → 284
      PH2_ARAP; ArfGAP with RhoGAP domain, ankyrin repeat and PH domain Pleckstrin homology (PH) domain, repeat 2
      cd13256
      Location:502 → 607
      PH3_ARAP; ArfGAP with RhoGAP domain, ankyrin repeat and PH domain Pleckstrin homology (PH) domain, repeat 3
      cd13257
      Location:621 → 711
      PH4_ARAP; ArfGAP with RhoGAP domain, ankyrin repeat and PH domain Pleckstrin homology (PH) domain, repeat 4
      cd13259
      Location:1022 → 1161
      PH5_ARAP; ArfGAP with RhoGAP domain, ankyrin repeat and PH domain Pleckstrin homology (PH) domain, repeat 5
      pfam00788
      Location:931 → 1019
      RA; Ras association (RalGDS/AF-6) domain
      pfam01412
      Location:294 → 410
      ArfGap; Putative GTPase activating protein for Arf

    6. XM_023645806.1 → XP_023501574.1  arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 1 isoform X3

      UniProtKB/TrEMBL
      A0A9L0RMQ9
      Related
      ENSECAP00000065184.1, ENSECAT00000083795.1
      Conserved Domains (8) summary
      cd04385
      Location:716 → 894
      RhoGAP_ARAP; RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in ARAPs. ARAPs (also known as centaurin deltas) contain, besides the RhoGAP domain, an Arf GAP, ankyrin repeat ras-associating, and PH domains. Since their ArfGAP activity ...
      cd13253
      Location:88 → 180
      PH1_ARAP; ArfGAP with RhoGAP domain, ankyrin repeat and PH domain Pleckstrin homology (PH) domain, repeat 1
      cd13254
      Location:195 → 284
      PH2_ARAP; ArfGAP with RhoGAP domain, ankyrin repeat and PH domain Pleckstrin homology (PH) domain, repeat 2
      cd13256
      Location:502 → 607
      PH3_ARAP; ArfGAP with RhoGAP domain, ankyrin repeat and PH domain Pleckstrin homology (PH) domain, repeat 3
      cd13257
      Location:621 → 711
      PH4_ARAP; ArfGAP with RhoGAP domain, ankyrin repeat and PH domain Pleckstrin homology (PH) domain, repeat 4
      cd13259
      Location:1022 → 1161
      PH5_ARAP; ArfGAP with RhoGAP domain, ankyrin repeat and PH domain Pleckstrin homology (PH) domain, repeat 5
      pfam00788
      Location:931 → 1019
      RA; Ras association (RalGDS/AF-6) domain
      pfam01412
      Location:294 → 410
      ArfGap; Putative GTPase activating protein for Arf
    Nucleotide Protein
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