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    RYR3 ryanodine receptor 3 [ Oryctolagus cuniculus (rabbit) ]

    Gene ID: 100009545, updated on 3-Apr-2024

    Summary

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    Gene symbol
    RYR3
    Gene description
    ryanodine receptor 3
    See related
    Ensembl:ENSOCUG00000011459
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Oryctolagus cuniculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Lagomorpha; Leporidae; Oryctolagus
    Also known as
    RYR-3
    Annotation information
    Annotation category: partial on reference assembly
    Orthologs
    human mouse all
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    Genomic context

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    See RYR3 in Genome Data Viewer
    Location:
    chromosome: 17
    Exon count:
    104
    Annotation release Status Assembly Chr Location
    RS_2023_02 current UM_NZW_1.0 (GCF_009806435.1) 17 NC_067390.1 (39452330..40047439)

    Chromosome 17 - NC_067390.1Genomic Context describing neighboring genes Neighboring gene formin 1 Neighboring gene small nucleolar RNA SNORD52 Neighboring gene transmembrane and coiled-coil domain-containing protein 5B Neighboring gene H/ACA ribonucleoprotein complex subunit 3 Neighboring gene apoptosis and caspase activation inhibitor Neighboring gene small nucleolar RNA SNORA11 Neighboring gene cholinergic receptor muscarinic 5

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_067390.1 Chromosome 17 Reference UM_NZW_1.0 Primary Assembly

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Calmodulin regulation and identification of calmodulin binding region of type-3 ryanodine receptor calcium release channel. Yamaguchi N, et al. Biochemistry, 2005 Nov 15. PMID 16274254
    2. Selective expression of the type 3 isoform of ryanodine receptor Ca2+ release channel (RyR3) in a subset of slow fibers in diaphragm and cephalic muscles of adult rabbits. Conti A, et al. Biochem Biophys Res Commun, 2005 Nov 11. PMID 16176801
    3. Molecular identification of the ryanodine receptor Ca2+ sensor. Chen SR, et al. J Biol Chem, 1998 Jun 12. PMID 9614063
    4. Functional characterization of the recombinant type 3 Ca2+ release channel (ryanodine receptor) expressed in HEK293 cells. Chen SR, et al. J Biol Chem, 1997 Sep 26. PMID 9305876
    5. Primary structure and distribution of a novel ryanodine receptor/calcium release channel from rabbit brain. Hakamata Y, et al. FEBS Lett, 1992 Nov 9. PMID 1330694

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables calcium ion binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables protein binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables ryanodine-sensitive calcium-release channel activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in calcium ion transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in intracellular calcium ion homeostasis IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in Z disc IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    part_of calcium channel complex IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in sarcolemma IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in sarcoplasmic reticulum membrane IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in smooth endoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    ryanodine receptor 3
    Names
    Brain ryanodine receptor-calcium release channel
    Brain-type ryanodine receptor
    Type 3 ryanodine receptor

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001082762.1 → NP_001076231.1  ryanodine receptor 3

      See identical proteins and their annotated locations for NP_001076231.1

      Status: PROVISIONAL

      Source sequence(s)
      X68650
      UniProtKB/Swiss-Prot
      Q9TS33
      UniProtKB/TrEMBL
      A0A5F9DFF8
      Related
      ENSOCUP00000037369.1, ENSOCUT00000057581.1
      Conserved Domains (12) summary
      smart00472
      Location:275 → 368
      MIR; Domain in ryanodine and inositol trisphosphate receptors and protein O-mannosyltransferases
      cd12877
      Location:641 → 792
      SPRY1_RyR; SPRY domain 1 (SPRY1) of ryanodine receptor (RyR)
      pfam00520
      Location:4623 → 4783
      Ion_trans; Ion transport protein
      pfam01365
      Location:442 → 621
      RYDR_ITPR; RIH domain
      pfam02026
      Location:849 → 937
      RyR; RyR domain
      pfam02815
      Location:216 → 397
      MIR; MIR domain
      pfam06459
      Location:4236 → 4506
      RR_TM4-6; Ryanodine Receptor TM 4-6
      pfam08454
      Location:3733 → 3846
      RIH_assoc; RyR and IP3R Homology associated
      pfam13833
      Location:3937 → 3985
      EF-hand_8; EF-hand domain pair
      cd12879
      Location:1324 → 1462
      SPRY3_RyR; SPRY domain 3 (SPRY3) of ryanodine receptor (RyR)
      cl02614
      Location:1072 → 1204
      SPRY; SPRY domain
      cl19745
      Location:12 → 207
      Ins145_P3_rec; Inositol 1,4,5-trisphosphate/ryanodine receptor

    RefSeqs of Annotated Genomes: GCF_009806435.1-RS_2023_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference UM_NZW_1.0 Primary Assembly

    Genomic

    1. NC_067390.1 Reference UM_NZW_1.0 Primary Assembly

      Range
      39452330..40047439
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_051821716.1 → XP_051677676.1  ryanodine receptor 3 isoform X1

      UniProtKB/TrEMBL
      G1T1E2
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9TS33.1 GenPept UniProtKB/Swiss-Prot:Q9TS33

    Gene LinkOut

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