SLC9A3 solute carrier family 9 member A3 [Oryctolagus cuniculus (rabbit)] - Gene

Summary

Gene symbol: SLC9A3
Gene description: solute carrier family 9 member A3
See related: Ensembl:ENSOCUG00000011055
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Oryctolagus cuniculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Lagomorpha; Leporidae; Oryctolagus
Also known as: NHE-3
Annotation information: Annotation category: partial on reference assembly
Orthologs: human mouse all
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Genomic context

Location:: chromosome: Un

Exon count:: 1

Annotation release	Status	Assembly	Chr	Location
RS_2023_02	current	UM_NZW_1.0 (GCF_009806435.1)	Unplaced Scaffold	NW_026259818.1 (12043..12374, complement)

NW_026259818.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NW_026259818 Unplaced Scaffold Reference UM_NZW_1.0 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Lysophosphatidic acid stimulation of NHE3 exocytosis includes a signaling pathway that regulates fixation of NHE3 to the microvillar cytoskeleton.
Title: Lysophosphatidic acid stimulation of NHE3 exocytosis in polarized epithelial cells occurs with release from NHERF2 via ERK-PLC-PKCδ signaling.
1) NHE3 basal activity is regulated by a signaling complex that is controlled by sequential effects of two kinases, Akt and GSK-3, which act on a Ser cluster in the same NHE3 C-terminal domain that binds ezrin
Title: AKT and GSK-3 are necessary for direct ezrin binding to NHE3 as part of a C-terminal stimulatory complex: role of a novel Ser-rich NHE3 C-terminal motif in NHE3 activity and trafficking.
CaMKII binding to and phosphorylation of the NHE3 C terminus are parts of the physiologic regulation of NHE3 that occurs in fibroblasts as well as in the brush border of an intestinal Na(+)-absorptive cell.
Title: Calmodulin kinase II constitutively binds, phosphorylates, and inhibits brush border Na+/H+ exchanger 3 (NHE3) by a NHERF2 protein-dependent process.
Regulation of NHE3 depends on the nature of the NHERF family member associating with NHE3 and the accompanying NHE3 complexes.
Title: Elevated intracellular calcium stimulates NHE3 activity by an IKEPP (NHERF4) dependent mechanism.

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General gene information

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Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables sodium:proton antiporter activity	IEA Inferred from Electronic Annotation more info	PubMed

Process	Evidence Code	Pubs
involved_in proton transmembrane transport	IEA Inferred from Electronic Annotation more info	PubMed
involved_in regulation of pH	IEA Inferred from Electronic Annotation more info	PubMed
involved_in sodium ion transport	IEA Inferred from Electronic Annotation more info	PubMed

Component	Evidence Code	Pubs
located_in apical plasma membrane	IEA Inferred from Electronic Annotation more info	PubMed
located_in brush border membrane	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

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Preferred Names: sodium/hydrogen exchanger 3

Names: Na(+)/H(+) exchanger 3; Na+/H+ exchanger homolog; Na/H exchanger 3; solute carrier family 9 member 3; solute carrier family 9, subfamily A (NHE3, cation proton antiporter 3), member 3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001082697.1 → NP_001076166.1 sodium/hydrogen exchanger 3 precursor

See identical proteins and their annotated locations for NP_001076166.1

Status: PROVISIONAL

Source sequence(s)

M87007

UniProtKB/Swiss-Prot

P26432

UniProtKB/TrEMBL

A0A5F9DK76

Related

ENSOCUP00000046707.1, ENSOCUT00000042983.1

Conserved Domains (2) summary

TIGR00840
Location:47 → 646

b_cpa1; sodium/hydrogen exchanger 3

pfam00999
Location:104 → 461

Na_H_Exchanger; Sodium/hydrogen exchanger family