Official Symbol

CDC27provided by HGNC

Official Full Name

cell division cycle 27 homolog (S. cerevisiae)provided by HGNC

Primary Source

HGNC:1728

See related

Ensembl:ENSG00000004897; HPRD:00304; MIM:116946

Gene type

protein coding

RefSeq status

REVIEWED

Organism

Homo sapiens

Lineage

Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo

Also known as

APC3; HNUC; CDC27Hs; D0S1430E; D17S978E; CDC27

Summary

The protein encoded by this gene shares strong similarity with Saccharomyces cerevisiae protein Cdc27, and the gene product of Schizosaccharomyces pombe nuc 2. This protein is a component of anaphase-promoting complex (APC), which is composed of eight protein subunits and highly conserved in eucaryotic cells. APC catalyzes the formation of cyclin B-ubiquitin conjugate that is responsible for the ubiquitin-mediated proteolysis of B-type cyclins. This protein and 3 other members of the APC complex contain the TPR (tetratricopeptide repeat), a protein domain important for protein-protein interaction. This protein was shown to interact with mitotic checkpoint proteins including Mad2, p55CDC and BUBR1, and thus may be involved in controlling the timing of mitosis. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq]

(minus strand) Go to reference sequence detailsTry our new Sequence Viewer

chromosome: 17; Location: 17q12-q23.2See CDC27 in MapViewer

Preferred Names

cell division cycle protein 27

Names

cell division cycle protein 27

nuc2 homolog

anaphase-promoting complex, protein 3

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

1. NM_001114091.1 → NP_001107563.1  cell division cycle protein 27 isoform 1

   Description

   Transcript Variant: This variant (1) encodes the longer isoform (1).

   Source sequence(s)

   AC002558,BC011656,BP234964,S78234

   Consensus CDS

   CCDS45720.1

   UniProtKB/Swiss-Prot

   P30260

   Conserved Domains (1) summary

   cd00189
   Location:574 – 673
   Blast Score: 236

   TPR; Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]-X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...

2. NM_001256.3 → NP_001247.3  cell division cycle protein 27 isoform 2

   Description

   Transcript Variant: This variant (2) has an alternate splice site, as compared to variant 1. The resulting isoform 2 lacks an internal segment and has the same N- and C-termini, as compared to isoform 1.

   Source sequence(s)

   AC002558,BP234964,S78234

   Consensus CDS

   CCDS11509.1

   UniProtKB/Swiss-Prot

   P30260

   Conserved Domains (1) summary

   cd00189
   Location:568 – 667
   Blast Score: 236

   TPR; Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]-X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...

RefSeqs of Annotated Genomes: Build 37.1

The following sections contain reference sequences that belong to a specific genome build. Explain

This section includes genomic Reference Sequences (RefSeqs) from all assemblies on which this gene is annotated, such as RefSeqs for chromosomes and scaffolds (contigs) from both reference and alternate assemblies. Model RNAs and proteins are also reported here.

Genome Reference Consortium Human Build 37 (GRCh37), Primary_Assembly

Genomic

1. NC_000017.10

   Range

   45195309..45266664, complement

   Download

   GenBank FASTA Sequence Viewer (Graphics)

2. NT_010783.15 

   Range

   10469461..10540816, complement

   Download

   GenBank FASTA Sequence Viewer (Graphics)

Alternate assembly (Celera)

Genomic

1. AC_000060.1

   Range

   41645339..41716723, complement

   Download

   GenBank FASTA Sequence Viewer (Graphics)

2. NW_926883.1 

   Range

   418498..489882, complement

   Download

   GenBank FASTA Sequence Viewer (Graphics)

Alternate assembly (HuRef)

Genomic

1. AC_000149.1

   Range

   40572495..40644749, complement

   Download

   GenBank FASTA Sequence Viewer (Graphics)

2. NW_001838448.1 

   Range

   440475..512729, complement

   Download

   GenBank FASTA Sequence Viewer (Graphics)