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1: CDC16 cell division cycle 16 homolog (S. cerevisiae) [ Homo sapiens ]

GeneID: 8881 updated 21-Nov-2009

[Top][Help]Summary

Official Symbol
CDC16provided by HGNC
Official Full Name
cell division cycle 16 homolog (S. cerevisiae)provided by HGNC
Primary Source
HGNC:1720
See related
Ensembl:ENSG00000130177; HPRD:04587; MIM:603461
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
APC6; CDC16
Summary
This gene encodes a component protein of the APC complex, which is composed of eight proteins and functions as a protein ubiquitin ligase. The APC complex is a cyclin degradation system that governs exit from mitosis. Each component protein of the APC complex is highly conserved among eukaryotic organisms. This protein and two other APC complex proteins, CDC23 and CDC27, contain a tetratricopeptide repeat (TPR), a protein domain that may be involved in protein-protein interaction. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq]

[Top][Help]Genomic regions, transcripts, and products

(plus) Go to reference sequence detailsTry our new Sequence Viewer


[Top][Help]Genomic context

chromosome: 13; Location: 13q34See CDC16 in MapViewer

[Top][Help]Bibliography

Related Articles in PubMed

GeneRIFs: Gene References Into Function What's a GeneRIF?

PubMed 1. We report gene alterations in several components of this complex in human colon cancer cells, including APC6/CDC16 and APC8/CDC23 which are known to be key function elements.
PubMed 2. TFDP1, CUL4A, and CDC16 are probable targets of an amplification mechanism and therefore may be involved, together or separately, in development and/or progression of some hepatocellular carcinomas
Submit: New GeneRIF Correction

[Top][Help]Interactions

Description ..........
  Product Interactant Other Gene Complex Source Pubs          
 
  NP_003894.2   NP_057321.2   ANAPC5      HPRD    PubMed
 
  NP_003894.2   Mitotic checkpoint kinase MAD3L   BUB1B      HPRD    PubMed
 
  NP_003894.2   NP_001246.1   CDC20      HPRD    PubMed
 
  NP_003894.2   NP_001247.2   CDC27      HPRD    PubMed
 
  NP_003894.2   NP_002349.1   MAD2L1      HPRD    PubMed
 
  NP_003894.2   Protein phosphatase 5 catalytic subunit   PPP5C      HPRD    PubMed
 
  NP_003894.2   NP_005405.1   SKIL      HPRD    PubMed
 
  NP_003894.2   NP_005892.1   SMAD2      HPRD    PubMed
 
  NP_003894.2   NP_005893.1   SMAD3      HPRD    PubMed
Co-purification
  BioGRID:114400   BioGRID:122229   ANAPC1      BioGRID    PubMed
Affinity Capture-Western
  BioGRID:114400   BioGRID:118982   ANAPC4      BioGRID    PubMed
Affinity Capture-Western
  BioGRID:114400   BioGRID:115585   APC2      BioGRID    PubMed
Affinity Capture-Western
  BioGRID:114400   BioGRID:107166   BUB1B      BioGRID    PubMed
Affinity Capture-Western; Reconstituted Complex
  BioGRID:114400   BioGRID:107427   CDC20      BioGRID    PubMed
Affinity Capture-Western; Two-hybrid
  BioGRID:114400   BioGRID:107431   CDC27      BioGRID    PubMed
Reconstituted Complex
  BioGRID:114400   BioGRID:107434   CDH1      BioGRID    PubMed
Two-hybrid
  BioGRID:114400   BioGRID:202349   Ppp5c      BioGRID    PubMed
Affinity Capture-Western
  BioGRID:114400   BioGRID:110262   SMAD2      BioGRID    PubMed
Affinity Capture-Western
  BioGRID:114400   BioGRID:110263   SMAD3      BioGRID    PubMed
Affinity Capture-Western
  BioGRID:114400   BioGRID:113123   TTK      BioGRID    PubMed

[Top][Help]General gene information

Markers

A009U45(e-PCR)
Links: UniSTS:68098
SHGC-10931(e-PCR)
Links: UniSTS:25103
CDC16(e-PCR)
Links: UniSTS:505386
G35279(e-PCR)
Links: UniSTS:75332
D13S1160(e-PCR)
Links: UniSTS:36945
GDB:229301(e-PCR)
Links: UniSTS:156258
D13S667E(e-PCR)
Links: UniSTS:153199
RH47113(e-PCR)
Links: UniSTS:81803
G19778(e-PCR)
Links: UniSTS:60559
A001Y17(e-PCR)
Links: UniSTS:60560
RH1616(e-PCR)
Links: UniSTS:34484
G32861(e-PCR)
Links: UniSTS:117440
D13S327(e-PCR)
Links: UniSTS:148681
D13S1825(e-PCR), detects polymorphism
Links: UniSTS:79821

Homology

Homologs of the CDC16 gene The CDC16 gene is conserved in chimpanzee, dog, cow, mouse, rat, chicken, zebrafish, fruit fly, mosquito, S.pombe, S.cerevisiae, K.lactis, E.gossypii, M.grisea, N.crassa, A.thaliana, and rice.


Map Viewer (Mouse, Rat)

Pathways

KEGG pathway: Cell cycle
04110
KEGG pathway: Progesterone-mediated oocyte maturation
04914
KEGG pathway: Ubiquitin mediated proteolysis
04120
Reactome Event:Cell Cycle Checkpoints
REACT_1538
Reactome Event:Cell Cycle, Mitotic
REACT_152

[Top][Help]General protein information

Preferred Names
anaphase-promoting complex, subunit 6
Names
anaphase-promoting complex, subunit 6

[Top][Help]NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

mRNA and Protein(s)

  1. NM_001078645.1 → NP_001072113.1  anaphase-promoting complex, subunit 6

    Description
    Transcript Variant: This variant represents the shorter transcript. Variants 1 and 2 encode the same isoform.
    Source sequence(s)
    AL160396,BC017244
    Consensus CDS
    CCDS9542.2
    UniProtKB/Swiss-Prot
    Q13042
    UniProtKB/TrEMBL
    Q5T8C8
    Conserved Domains (2) summary
    cd00189
    Location:447 – 536
    Blast Score: 126
    TPR; Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]-X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...
    TIGR02917
    Location:134 – 502
    Blast Score: 88
    PEP_TPR_lipo; putative PEP-CTERM system TPR-repeat lipoprotein

  2. NM_003903.3 → NP_003894.3  anaphase-promoting complex, subunit 6

    Description
    Transcript Variant: This variant represents the longer transcript. Variants 1 and 2 encode the same isoform.
    Source sequence(s)
    AL160396,BC017244
    Consensus CDS
    CCDS9542.2
    UniProtKB/Swiss-Prot
    Q13042
    UniProtKB/TrEMBL
    Q5T8C8
    Conserved Domains (2) summary
    cd00189
    Location:447 – 536
    Blast Score: 126
    TPR; Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]-X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...
    TIGR02917
    Location:134 – 502
    Blast Score: 88
    PEP_TPR_lipo; putative PEP-CTERM system TPR-repeat lipoprotein

RefSeqs of Annotated Genomes: Build 37.1

The following sections contain reference sequences that belong to a specific genome build. Explain

Genome Reference Consortium Human Build 37 (GRCh37), Primary_Assembly

Genomic

  1. NC_000013.10

    Range
    115000361..115038149
    Download
    GenBank FASTA Sequence Viewer (Graphics)

  2. NT_024498.12 

    Range
    260413..298201
    Download
    GenBank FASTA Sequence Viewer (Graphics)

Alternate assembly (Celera)

Genomic

  1. AC_000056.1

    Range
    95672732..95710521
    Download
    GenBank FASTA Sequence Viewer (Graphics)

  2. NW_925517.1 

    Range
    27925933..27963722
    Download
    GenBank FASTA Sequence Viewer (Graphics)

Alternate assembly (HuRef)

Genomic

  1. AC_000145.1

    Range
    95262577..95300344, complement
    Download
    GenBank FASTA Sequence Viewer (Graphics)

  2. NW_001838087.2 

    Range
    80454..118221, complement
    Download
    GenBank FASTA Sequence Viewer (Graphics)

[Top][Help]Related Sequences

  Nucleotide   Protein
  genomic   AL160396.33   CAI15810.1
       CAI15811.1
       CAI15812.1
  genomic   AY599074.1   AAS94323.1
  genomic   CH471085.1   EAX09237.1
       EAX09238.1
       EAX09239.1
       EAX09240.1
       EAX09241.1
       EAX09242.1
       EAX09243.1
       EAX09244.1
       EAX09245.1
  mRNA   AB209850.1   BAD93087.1
  mRNA   AF164598.1   AAD45156.1
  mRNA   AK095082.1   None
  mRNA   AK296424.1   BAG59086.1
  mRNA   AK315302.1   BAG37707.1
  mRNA   AL540490.3   None
  mRNA   BC010875.2   AAH10875.1
  mRNA   BC017244.1   AAH17244.1
  mRNA   BC050575.1   None
  mRNA   CR626847.1   None
  mRNA   U18291.1   AAC50200.1
Protein Accession   Links
Q13042.2   GenPept   UniProtKB/Swiss-Prot:Q13042
Q59EG1   GenPept   UniProtKB/TrEMBL:Q59EG1
Q5T8C6   GenPept   UniProtKB/TrEMBL:Q5T8C6
Q5T8C8   GenPept   UniProtKB/TrEMBL:Q5T8C8
Q7Z651   GenPept   UniProtKB/TrEMBL:Q7Z651

[Top][Help]Additional Links