Official Symbol

CAMK1provided by HGNC

Official Full Name

calcium/calmodulin-dependent protein kinase Iprovided by HGNC

Primary Source

HGNC:1459

See related

Ensembl:ENSG00000134072; HPRD:05412; MIM:604998

Gene type

protein coding

RefSeq status

REVIEWED

Organism

Homo sapiens

Lineage

Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo

Also known as

CAMKI; MGC120317; MGC120318; CAMK1

Summary

Calcium/calmodulin-dependent protein kinase I is expressed in many tissues and is a component of a calmodulin-dependent protein kinase cascade. Calcium/calmodulin directly activates calcium/calmodulin-dependent protein kinase I by binding to the enzyme and indirectly promotes the phosphorylation and synergistic activation of the enzyme by calcium/calmodulin-dependent protein kinase I kinase. [provided by RefSeq]

(minus strand) Go to reference sequence detailsTry our new Sequence Viewer

chromosome: 3; Location: 3p25.3See CAMK1 in MapViewer

Go to the HIV-1, Human Protein Interaction Database

Preferred Names

calcium/calmodulin-dependent protein kinase I

Names

calcium/calmodulin-dependent protein kinase I

NP_003647.1

EC 2.7.11.17

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

1. NM_003656.3 → NP_003647.1  calcium/calmodulin-dependent protein kinase I

   Source sequence(s)

   BI546222,L41816

   Consensus CDS

   CCDS2582.1

   UniProtKB/TrEMBL

   B0YIY3

   UniProtKB/Swiss-Prot

   Q14012

   Conserved Domains (2) summary

   cd00180
   Location:20 – 276
   Blast Score: 792

   S_TKc; Serine/Threonine protein kinases, catalytic domain. Phosphotransferases of the serine or threonine-specific kinase subfamily. The enzymatic activity of these protein kinases is controlled by phosphorylation of specific residues in the activation...

   smart00220
   Location:30 – 276
   Blast Score: 869

   S_TKc; Serine/Threonine protein kinases, catalytic domain

RefSeqs of Annotated Genomes: Build 37.1

The following sections contain reference sequences that belong to a specific genome build. Explain

This section includes genomic Reference Sequences (RefSeqs) from all assemblies on which this gene is annotated, such as RefSeqs for chromosomes and scaffolds (contigs) from both reference and alternate assemblies. Model RNAs and proteins are also reported here.

Genome Reference Consortium Human Build 37 (GRCh37), Primary_Assembly

Genomic

1. NC_000003.11

   Range

   9799030..9811660, complement

   Download

   GenBank FASTA Sequence Viewer (Graphics)

2. NT_022517.18 

   Range

   9739030..9751660, complement

   Download

   GenBank FASTA Sequence Viewer (Graphics)

Alternate assembly (Celera)

Genomic

1. AC_000046.1

   Range

   9733732..9746361, complement

   Download

   GenBank FASTA Sequence Viewer (Graphics)

2. NW_921651.1 

   Range

   9733732..9746361, complement

   Download

   GenBank FASTA Sequence Viewer (Graphics)

Alternate assembly (HuRef)

Genomic

1. AC_000135.1

   Range

   9735378..9748009

   Download

   GenBank FASTA Sequence Viewer (Graphics)

2. NW_001838876.2 

   Range

   594424..607055

   Download

   GenBank FASTA Sequence Viewer (Graphics)