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1. |
SPG20 is ubiquitinated and interacts with AIP4 and AIP5. |
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2. |
AIP4 can interact directly with CXCR4 via a novel noncanonical WW domain-mediated interaction involving serine residues 324 and 325 within the carboxy-terminal tail of CXCR4. |
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3. |
Itch protein is a key regulatory locus for Epidermal Growth Factor receptor degradation. |
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4. |
Data show that the small PY-containing membrane proteins, NDFIP1 and NDFIP2 (NEDD4 family-interacting proteins), activate the catalytic activity of ITCH and of several other HECT ligases by binding to them. |
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5. |
Ectopic expression of miR106b in CLL cells demonstrated that Itch was a direct target of miR106b such that miR106b-induced decreases in Itch resulted in an accumulation of p73. |
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6. |
These data suggests that caspase-dependent Itch cleavage might be an important regulator of Itch at the endogenous level under both physiological and stressed conditions. |
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7. |
Itch gene sequence is highly conserved in healthy subjects; no relevant SNPs located in putative functional regions of Itch were found in atopic dermatitis and rheumatoid arthritis patients |
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8. |
Ubiquitination of cFLIP(L) inhibits the interaction between cFLIP(L) and Itch in T. cruzi-infected cells. |
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9. |
demonstrate that the decay rate of a catalytic inactive Itch mutant, which is devoided of self-ubiquitylating activity, is barely indistinguishable from the one of the wild-type protein |
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10. |
hypothesize a correlated slow-frequency motion that involves two different hinge regions of the HECT domain of itch |
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11. |
ITCH is a putative target for a novel 20q11.22 amplification detected in anaplastic thyroid carcinoma cells by array-based comparative genomic hybridization. |
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12. |
The modified Yap1 does not co-activate Runx in supporting Itch transcription. The subsequent reduction in the Itch level gives rise to p73 accumulation. |
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13. |
This is the first in vivo evidence for the interaction between p45/NF-E2 and the E3 ubiquitin ligase Itch, and the subsequent ubiquitination of p45/NF-E2 by Itch. |
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14. |
AIP4/Itch regulates Notch receptor degradation in the absence of ligand |
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15. |
the AIP4.arrestin-2 complex functions on endosomes to regulate sorting of CXCR4 into the degradative pathway |
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16. |
AIP4 restricts transforming growth factor-beta signaling through a ubiquitination-independent mechanism |
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17. |
AIP4-generated polyubiquitin chains are mainly conjugated through lysine 29 of ubiquitin in vivo, indicating a link between this type of chain and lysosomal degradation. |
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18. |
Hedgehog transcription factor Gli1 is targeted by Numb for Itch-dependent ubiquitination, which suppresses Hedgehog signals, thus arresting growth and promoting cell differentiation. |
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19. |
First demonstration of ubiquitin-protein ligase AIP4 from human lung cDNA library recruited by penton base proteins of adenovirus serotypes Ad2 and Ad3 in vitro and in vivo. |
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20. |
Data demonstrate that two E3 ligases of different classes, CBLC and AIP4, can interact and cooperate to down-regulate EGFR signaling. |
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21. |
The visualization of ubiquitinated Jun in living cells has uncovered a lysosomal pathway for Jun degradation that involves ubiquitination by Itch/AIP4. |
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22. |
Both neural precursor cell expressed, developmentally down-regulated 4 and Itch participate in the degradation of Melan-A |
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23. |
transient overexpression of FAM/USP9X resulted in the deubiquitylation of Itch. Moreover, we show that Itch auto-ubiquitylation leads to its degradation in the proteasome |
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24. |
Reults demonstrate the function of atrophin-1-interacting protein 4 as an ubiquitin E3 ligase for human enhancer of filamentation 1. |
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25. |
The tight junction-specific protein occludin is a functional target of the E3 ubiquitin-protein ligase itch |
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26. |
Upon DNA damage Itch itself is downregulated, allowing p73 protein levels to rise and thus interfere with p73 function |
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27. |
AIP4 promotes the endocytosis of TRPV4 and decreases its amount at the plasma membrane. TRPC4, another member of the TRP channel family, is also strongly ubiquitinated in the presence of AIP4 |
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28. |
Data show that the Nedd4-like E3 ubiquitin ligase AIP4 mediates ubiquitination of CXCR4 at the plasma membrane, and of the ubiquitin binding protein Hrs on endosomes. |
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29. |
CISK strongly interacts and colocalizes with the E3 ubiquitin ligase AIP4, which is important for the ubiquitin-dependent lysosomal degradation of CXCR4 |
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30. |
novel E3 ubiquitin-protein ligase; role in regulation of immune response - review |
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31. |
gene expression regulation; coregulates hematopoietic transcription factor NF-E2 |