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1: CAMK2G calcium/calmodulin-dependent protein kinase II gamma [ Homo sapiens ]

GeneID: 818 updated 8-Nov-2009

[Top][Help]Summary

Official Symbol
CAMK2Gprovided by HGNC
Official Full Name
calcium/calmodulin-dependent protein kinase II gammaprovided by HGNC
Primary Source
HGNC:1463
See related
Ensembl:ENSG00000148660; HPRD:03672; MIM:602123
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CAMK; CAMKG; CAMK-II; FLJ16043; MGC26678; CAMK2G
Summary
The product of this gene belongs to the Serine/Threonine protein kinase family, and to the Ca(2+)/calmodulin-dependent protein kinase subfamily. Calcium signaling is crucial for several aspects of plasticity at glutamatergic synapses. In mammalian cells the enzyme is composed of four different chains: alpha, beta, gamma, and delta. The product of this gene is a gamma chain. Six alternatively spliced variants that encode six different isoforms have been characterized to date. Additional alternative splice variants that encode different isoforms have been described, but their full-length nature has not been determined. [provided by RefSeq]

[Top][Help]Genomic regions, transcripts, and products

(minus strand) Go to reference sequence detailsTry our new Sequence Viewer


[Top][Help]Genomic context

chromosome: 10; Location: 10q22See CAMK2G in MapViewer

[Top][Help]Bibliography

Related Articles in PubMed

GeneRIFs: Gene References Into Function What's a GeneRIF?

PubMed 1. P2X7 receptor-triggered signalling pathways that regulate neurite formation in neuroblastoma cells.
PubMed 2. increased RyR2-dependent Ca2+ leakage due to enhanced CaMKII activity is an important downstream effect of CaMKII in individuals susceptible to AF induction.
PubMed 3. IGF-II/mannose-6-phosphate receptor signaling induced cell hypertrophy and atrial natriuretic peptide/BNP expression via Galphaq interaction and protein kinase C-alpha/CaMKII activation in H9c2 cardiomyoblast cells.
PubMed 4. In Turner yndrome, loss of voltage-dependent inactivation is an upstream initiating event for arrhythmia phenotypes that are ultimately dependent on CaMKII activation.
PubMed 5. CaMKIIgamma is a critical regulator of multiple signaling networks regulating the proliferation of myeloid leukemia cells
PubMed 6. Observational study of gene-disease association. (HuGE Navigator)
PubMed 7. insulin in the presence of Angiotensin II inhibits protein phosphatase-2A (PP-2A) and stimulates autonomous CaM kinase II activities and thus vascular smooth muscle migration
PubMed 8. CaMKIIgamma is necessary to suppress MCAK depolymerase activity in vivo.
PubMed 9. Amphetamine in a cell line induces a robust increase in cytosolic Ca2+ and concomitant activation of calcium/calmodulin-dependent protein kinase II (CaMKII).
PubMed 10. measured differences in CaMKII binding affinities for CaM play a minor role in the autophosphorylation of the enzyme, largely dictated by autophosphorylation rate for alpha, beta, gamma and delta isoforms
PubMed 11. cloning, genomic structure and detection of variants in subjects with Type II diabetes
PubMed 12. role in cell communication
PubMed 13. A transgenic, constitutively active, Ca2+-independent form of CaMKgamma reduces positive selection of T cells by maintaining association of SHP-2 with the T cell receptor (TCR) complex, and halting TCR signaling.
PubMed 14. Significant cross-talk between calcium and retinoic acid signaling pathways regulates the differentiation of myeloid leukemia cells.
Submit: New GeneRIF Correction

[Top][Help]Interactions

Description ..........
  Product Interactant Other Gene Complex Source Pubs          
 
  NP_751911.1   Actinin alpha 4   ACTN4      HPRD    PubMed
 
  NP_751911.1   NP_057450.1   CABP2      HPRD    PubMed
 
  NP_751911.1   Calmodulin 1   CALM1      HPRD    PubMed
 
  NP_751911.1   RAD   RRAD      HPRD    PubMed
 
  NP_751911.1   RAS related associated with diabetes   RRAD      HPRD    PubMed
 
  NP_751911.1   NP_005893.1   SMAD3      HPRD    PubMed
 
  NP_751911.1   NP_005350.1   SMAD4      HPRD    PubMed
 
  NP_751911.1   STAT1   STAT1      HPRD    PubMed
 
  NP_751911.1   T cell lymphoma invasion and metastasis 1   TIAM1      HPRD    PubMed
 
  NP_751911.1   CABP2        HPRD    PubMed
 
  NP_751911.1   Calmodulin        HPRD    PubMed
Reconstituted Complex
  BioGRID:107268   BioGRID:107252   CALM1      BioGRID    PubMed
Two-hybrid
  BioGRID:107268   BioGRID:250730   Lrrc7      BioGRID    PubMed
Biochemical Activity; Reconstituted Complex
  BioGRID:107268   BioGRID:112150   RRAD      BioGRID    PubMed
Biochemical Activity
  BioGRID:107268   BioGRID:110262   SMAD2      BioGRID    PubMed
Biochemical Activity
  BioGRID:107268   BioGRID:110264   SMAD4      BioGRID    PubMed

[Top][Help]General gene information

Markers

D11S2921(e-PCR)
Links: UniSTS:152074
SHGC-148964(e-PCR)
Links: UniSTS:173085
SHGC-148965(e-PCR)
Links: UniSTS:173086
D8S2278(e-PCR)
Links: UniSTS:473906
D8S2279(e-PCR)
Links: UniSTS:473907
sY3084(e-PCR)
Links: UniSTS:515126
SHGC-78184(e-PCR)
Links: UniSTS:96074
L18426(e-PCR)
Links: UniSTS:34648
D1S1423(e-PCR)
Links: UniSTS:149619
D1S1425(e-PCR)
Links: UniSTS:149621
SHGC-106444(e-PCR)
Links: UniSTS:182164
D11S3316(e-PCR)
Links: UniSTS:152558
D10S1737(e-PCR), detects polymorphism
Links: UniSTS:36085
WI-12185(e-PCR)
Links: UniSTS:81656
D10S483E(e-PCR)
Links: UniSTS:473082

Homology

Homologs of the CAMK2G gene The CAMK2G gene is conserved in dog, cow, mouse, rat, chicken, and zebrafish.


Map Viewer (Mouse, Rat)

Pathways

KEGG pathway: Calcium signaling pathway
04020
KEGG pathway: ErbB signaling pathway
04012
KEGG pathway: Glioma
05214
KEGG pathway: GnRH signaling pathway
04912
KEGG pathway: Long-term potentiation
04720
KEGG pathway: Melanogenesis
04916
KEGG pathway: Neurotrophin signaling pathway
04722
KEGG pathway: Olfactory transduction
04740
KEGG pathway: Wnt signaling pathway
04310
Reactome Event:Synaptic Transmission
REACT_13685

[Top][Help]General protein information

Preferred Names
calcium/calmodulin-dependent protein kinase II gamma
Names
calcium/calmodulin-dependent protein kinase II gamma
CaM kinase II
calcium/calmodulin-dependent protein kinase (CaM kinase) II gamma
NP_001213.2
EC 2.7.11.17
NP_751909.1
EC 2.7.11.17
NP_751910.1
EC 2.7.11.17
NP_751911.1
EC 2.7.11.17
NP_751913.1
EC 2.7.11.17

[Top][Help]NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

mRNA and Protein(s)

  1. NM_001222.2 → NP_001213.2  calcium/calmodulin-dependent protein kinase II gamma isoform 4

    Description
    Transcript Variant: This variant (4) lacks in-frame segments of the coding region, compared to variant 1. It encodes a shorter isoform (4), that is missing internal segments compared to isoform 1.
    Source sequence(s)
    BC034044,L07043
    Consensus CDS
    CCDS7336.1
    UniProtKB/TrEMBL
    O00561
    UniProtKB/Swiss-Prot
    Q13555
    UniProtKB/TrEMBL
    Q5SWX4
    Conserved Domains (3) summary
    cd00180
    Location:13 – 272
    Blast Score: 775
    S_TKc; Serine/Threonine protein kinases, catalytic domain. Phosphotransferases of the serine or threonine-specific kinase subfamily. The enzymatic activity of these protein kinases is controlled by phosphorylation of specific residues in the activation...
    smart00220
    Location:24 – 272
    Blast Score: 798
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cl09109
    Location:363 – 490
    Blast Score: 567
    NTF2_like; Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...

  2. NM_172169.1 → NP_751909.1  calcium/calmodulin-dependent protein kinase II gamma isoform 2

    Description
    Transcript Variant: This variant (2) has multiple coding region differences, compared to variant 1. This results in a shorter isoform (2), compared to isoform 1.
    Source sequence(s)
    BC034044
    Consensus CDS
    CCDS7337.1
    UniProtKB/Swiss-Prot
    Q13555
    Conserved Domains (3) summary
    cd00180
    Location:13 – 272
    Blast Score: 773
    S_TKc; Serine/Threonine protein kinases, catalytic domain. Phosphotransferases of the serine or threonine-specific kinase subfamily. The enzymatic activity of these protein kinases is controlled by phosphorylation of specific residues in the activation...
    smart00220
    Location:24 – 272
    Blast Score: 795
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cl09109
    Location:395 – 522
    Blast Score: 565
    NTF2_like; Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...

  3. NM_172170.3 → NP_751910.1  calcium/calmodulin-dependent protein kinase II gamma isoform 3

    Description
    Transcript Variant: This variant (3) lacks an in-frame segment of the coding region, compared to variant 1. It encodes a shorter isoform (3), that is missing an internal segment compared to isoform 1.
    Source sequence(s)
    AC022400,AL596247,AL713896

  4. NM_172171.1 → NP_751911.1  calcium/calmodulin-dependent protein kinase II gamma isoform 1

    Description
    Transcript Variant: This variant (1) represents the longest transcript, and encodes the longest isoform 1.
    Source sequence(s)
    BC034044,U66063
    Consensus CDS
    CCDS7338.1
    UniProtKB/TrEMBL
    Q13280
    UniProtKB/Swiss-Prot
    Q13555
    Conserved Domains (3) summary
    cd00180
    Location:13 – 272
    Blast Score: 789
    S_TKc; Serine/Threonine protein kinases, catalytic domain. Phosphotransferases of the serine or threonine-specific kinase subfamily. The enzymatic activity of these protein kinases is controlled by phosphorylation of specific residues in the activation...
    smart00220
    Location:24 – 272
    Blast Score: 811
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cl09109
    Location:424 – 551
    Blast Score: 573
    NTF2_like; Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...

  5. NM_172173.1 → NP_751913.1  calcium/calmodulin-dependent protein kinase II gamma isoform 6

    Description
    Transcript Variant: This variant (6) lacks in-frame segments of the coding region, compared to variant 1. It encodes a shorter isoform (6), that is missing internal segments compared to isoform 1.
    Source sequence(s)
    BC034044,U50360
    UniProtKB/Swiss-Prot
    Q13555
    Conserved Domains (3) summary
    cd00180
    Location:13 – 272
    Blast Score: 777
    S_TKc; Serine/Threonine protein kinases, catalytic domain. Phosphotransferases of the serine or threonine-specific kinase subfamily. The enzymatic activity of these protein kinases is controlled by phosphorylation of specific residues in the activation...
    smart00220
    Location:24 – 272
    Blast Score: 800
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cl09109
    Location:372 – 499
    Blast Score: 568
    NTF2_like; Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...

RefSeqs of Annotated Genomes: Build 37.1

The following sections contain reference sequences that belong to a specific genome build. Explain

Genome Reference Consortium Human Build 37 (GRCh37), Primary_Assembly

Genomic

  1. NC_000010.10

    Range
    75572258..75634342, complement
    Download
    GenBank FASTA Sequence Viewer (Graphics)

  2. NT_030059.13 

    Range
    26376722..26438806, complement
    Download
    GenBank FASTA Sequence Viewer (Graphics)

Alternate assembly (Celera)

Genomic

  1. AC_000053.1

    Range
    68855428..68917527, complement
    Download
    GenBank FASTA Sequence Viewer (Graphics)

  2. NW_924796.1 

    Range
    23049671..23111770, complement
    Download
    GenBank FASTA Sequence Viewer (Graphics)

Alternate assembly (HuRef)

Genomic

  1. AC_000142.1

    Range
    69567318..69629325
    Download
    GenBank FASTA Sequence Viewer (Graphics)

  2. NW_001837987.2 

    Range
    5826832..5888839
    Download
    GenBank FASTA Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

 

  1. NM_172172.1: Suppressed sequence

    Description
    NM_172172.1: This RefSeq was permanently suppressed because it is a nonsense-mediated mRNA decay (NMD) candidate.

[Top][Help]Related Sequences

  Nucleotide   Protein
  genomic   AC022400.9  (145210..183796)   None
  genomic   AF415177.1   AAM33514.1
  genomic   AL596247.22   CAI13964.1
       CAI13965.1
       CAI13966.1
       CAI13967.1
       CAI13968.1
  genomic   AL713896.9   CAI13787.1
       CAI13788.1
       CAI13789.1
       CAI13790.1
       CAI13791.1
  genomic   CH471083.1   EAW54527.1
       EAW54528.1
       EAW54529.1
       EAW54530.1
       EAW54531.1
       EAW54532.1
       EAW54533.1
       EAW54534.1
       EAW54535.1
       EAW54536.1
       EAW54537.1
       EAW54538.1
       EAW54539.1
       EAW54540.1
       EAW54541.1
       EAW54542.1
       EAW54543.1
  mRNA   AB209474.1   BAD92711.1
  mRNA   AK026309.1   None
  mRNA   AK094774.1   None
  mRNA   AK095576.1   BAG53089.1
  mRNA   AK131199.1   BAG54748.1
  mRNA   AK225771.1   None
  mRNA   AK291704.1   BAF84393.1
  mRNA   AK301180.1   BAG62765.1
  mRNA   BC012795.2   None
  mRNA   BC021269.2   AAH21269.2
  mRNA   BC034044.1   AAH34044.1
  mRNA   BC037928.1   None
  mRNA   BU165166.1   None
  mRNA   CR613060.1   None
  mRNA   CR618627.1   None
  mRNA   L07043.1   AAB61379.1
  mRNA   L07044.1   None
  mRNA   U32472.1   AAA75201.1
  mRNA   U32473.1   AAA75202.1
  mRNA   U32509.1   AAA75203.1
  mRNA   U50359.1   AAB16864.1
  mRNA   U50360.1   AAB16865.1
  mRNA   U66063.1   AAB80847.1
  mRNA   U66064.1   AAB80848.1
  other-genetic   DQ892365.2   ABM83291.1
  other-genetic   DQ895574.2   ABM86500.1
  other-genetic   DQ896692.2   ABM87691.1
Protein Accession   Links
O00561   GenPept   UniProtKB/TrEMBL:O00561
Q13280   GenPept   UniProtKB/TrEMBL:Q13280
Q13555.3   GenPept   UniProtKB/Swiss-Prot:Q13555
Q59FI6   GenPept   UniProtKB/TrEMBL:Q59FI6
Q5SWX3   GenPept   UniProtKB/TrEMBL:Q5SWX3
Q5SWX4   GenPept   UniProtKB/TrEMBL:Q5SWX4
Q8WU40   GenPept   UniProtKB/TrEMBL:Q8WU40

[Top][Help]Additional Links