1: CAMK2D calcium/calmodulin-dependent protein kinase II delta [ Homo sapiens ]

GeneID: 817 updated 25-Nov-2009

[Top][Help]Summary

Official Symbol
CAMK2Dprovided by HGNC
Official Full Name
calcium/calmodulin-dependent protein kinase II deltaprovided by HGNC
Primary Source
HGNC:1462
See related
Ensembl:ENSG00000145349; HPRD:09653; MIM:607708
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CAMKD; MGC44911; DKFZp686I2288; DKFZp686G23119; CAMK2D
Summary
The product of this gene belongs to the serine/threonine protein kinase family and to the Ca(2+)/calmodulin-dependent protein kinase subfamily. Calcium signaling is crucial for several aspects of plasticity at glutamatergic synapses. In mammalian cells, the enzyme is composed of four different chains: alpha, beta, gamma, and delta. The product of this gene is a delta chain. Alternative splicing results in multiple transcript variants encoding distinct isoforms. Distinct isoforms of this chain have different expression patterns.

[Top][Help]Genomic regions, transcripts, and products

(minus strand) Go to reference sequence detailsTry our new Sequence Viewer


[Top][Help]Genomic context

chromosome: 4; Location: 4q26See CAMK2D in MapViewer

[Top][Help]Bibliography

Related Articles in PubMed

GeneRIFs: Gene References Into Function What's a GeneRIF?

PubMed 1. Observational study and genome-wide association study of gene-disease association. (HuGE Navigator)
PubMed 2. Chronic upregulation/activation of CaMKIID, and PKD in heart failure shifts HDAC5 out of the nucleus, derepressing transcription of hypertrophic genes.
PubMed 3. measured differences in CaMKII binding affinities for CaM play a minor role in the autophosphorylation of the enzyme, largely dictated by autophosphorylation rate for alpha, beta, gamma and delta isoforms
PubMed 4. role in cell communication
PubMed 5. HDAC4 as a specific downstream substrate of CaMKIIdeltaB in cardiac cells and have broad applications for the signaling pathways leading to cardiac hypertrophy and heart failure.
PubMed 6. LPS and TNF-alpha, enhance monocytic cell survival through the induction of the antiapoptotic c-IAP2 gene in a human promonocytic THP-1 cell line.
Submit: New GeneRIF Correction

[Top][Help]Interactions

Description ..........
  Product Interactant Other Gene Complex Source Pubs          
Affinity Capture-MS
  BioGRID:107267   BioGRID:107265   CAMK2A      BioGRID    PubMed
Affinity Capture-Western
  BioGRID:107267   BioGRID:112136   RPS18      BioGRID    PubMed

[Top][Help]General gene information

Markers

D4S1497E(e-PCR)
Links: UniSTS:473137
SHGC-30731(e-PCR)
Links: UniSTS:41277
SHGC-8607(e-PCR)
Links: UniSTS:83778
EST02144(e-PCR)
Links: UniSTS:82781
D4S967(e-PCR)
Links: UniSTS:76126
RH120847(e-PCR)
Links: UniSTS:133502
SHGC-58101(e-PCR)
Links: UniSTS:37502
SHGC-23829(e-PCR)
Links: UniSTS:51071
G33061(e-PCR)
Links: UniSTS:117637
SHGC-50970(e-PCR)
Links: UniSTS:29578
SHGC-23830(e-PCR)
Links: UniSTS:30346
SHGC-8542(e-PCR)
Links: UniSTS:25756
G32826(e-PCR)
Links: UniSTS:117405
D4S1366(e-PCR)
Links: UniSTS:32929
A009S43(e-PCR)
Links: UniSTS:43938
SHGC-30317(e-PCR)
Links: UniSTS:181
SHGC-67300(e-PCR)
Links: UniSTS:87999
D4S2577E(e-PCR)
Links: UniSTS:150981
SHGC-24808(e-PCR)
Links: UniSTS:1482
SHGC-50558(e-PCR)
Links: UniSTS:1483
A010A47(e-PCR)
Links: UniSTS:71122
D4S3165(e-PCR)
Links: UniSTS:18134
STS-H54295(e-PCR)
Links: UniSTS:78301
D4S1611(e-PCR), detects polymorphism
Links: UniSTS:10207
D4S3167(e-PCR)
Links: UniSTS:17119
STS-R98767(e-PCR)
Links: UniSTS:66280
D4S1611(e-PCR), detects polymorphism
Links: UniSTS:12269
D4S448(e-PCR)
Links: UniSTS:22771

Homology

Homologs of the CAMK2D gene The CAMK2D gene is conserved in chimpanzee, dog, cow, mouse, rat, chicken, zebrafish, fruit fly, mosquito, and C.elegans.


Map Viewer (Mouse, Rat)

Pathways

KEGG pathway: Calcium signaling pathway
04020
KEGG pathway: ErbB signaling pathway
04012
KEGG pathway: Glioma
05214
KEGG pathway: GnRH signaling pathway
04912
KEGG pathway: Long-term potentiation
04720
KEGG pathway: Melanogenesis
04916
KEGG pathway: Neurotrophin signaling pathway
04722
KEGG pathway: Olfactory transduction
04740
KEGG pathway: Wnt signaling pathway
04310
Reactome Event:Synaptic Transmission
REACT_13685

[Top][Help]General protein information

Preferred Names
calcium/calmodulin-dependent protein kinase II delta
Names
calcium/calmodulin-dependent protein kinase II delta
OTTHUMP00000163830
CaMK-II delta subunit
CaM-kinase II delta chain
CaM kinase II delta subunit
calcium/calmodulin-dependent protein kinase type II delta chain
calcium/calmodulin-dependent protein kinase (CaM kinase) II delta
NP_001212.2
EC 2.7.11.17
NP_742112.1
EC 2.7.11.17
NP_742113.1
EC 2.7.11.17
NP_742125.1
EC 2.7.11.17
NP_742126.1
EC 2.7.11.17
NP_742127.1
EC 2.7.11.17

[Top][Help]NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

mRNA and Protein(s)

  1. NM_001221.3 → NP_001212.2  calcium/calmodulin-dependent protein kinase II delta isoform 3

    Description
    Transcript Variant: This variant (3) represents the longest transcript and encodes the longest isoform (3).
    Source sequence(s)
    AB209288,AC093900,AI057019,AK055642,CF551834,DA113081
    Consensus CDS
    CCDS3703.1
    UniProtKB/TrEMBL
    A8MVS8
    UniProtKB/Swiss-Prot
    Q13557
    Conserved Domains (3) summary
    cd00180
    Location:13 – 272
    Blast Score: 786
    S_TKc; Serine/Threonine protein kinases, catalytic domain. Phosphotransferases of the serine or threonine-specific kinase subfamily. The enzymatic activity of these protein kinases is controlled by phosphorylation of specific residues in the activation...
    smart00220
    Location:24 – 272
    Blast Score: 821
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cl09109
    Location:346 – 473
    Blast Score: 609
    NTF2_like; Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...

  2. NM_172114.1 → NP_742112.1  calcium/calmodulin-dependent protein kinase II delta isoform 5

    Description
    Transcript Variant: This variant (6) has multiple differences in the 3' coding region, compared to variant 3. The resulting isoform (5) has a shorter C-terminus, compared to isoform 3.
    Source sequence(s)
    AB209288,AI057019,BC032784,DA113081
    Consensus CDS
    CCDS47127.1
    UniProtKB/Swiss-Prot
    Q13557
    Conserved Domains (3) summary
    cd00180
    Location:13 – 272
    Blast Score: 784
    S_TKc; Serine/Threonine protein kinases, catalytic domain. Phosphotransferases of the serine or threonine-specific kinase subfamily. The enzymatic activity of these protein kinases is controlled by phosphorylation of specific residues in the activation...
    smart00220
    Location:24 – 272
    Blast Score: 819
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cl09109
    Location:360 – 487
    Blast Score: 606
    NTF2_like; Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...

  3. NM_172115.2 → NP_742113.1  calcium/calmodulin-dependent protein kinase II delta isoform 1

    Description
    Transcript Variant: This variant (4) has multiple differences in the 3' coding region, compared to variant 3. The resulting isoform (1) has a shorter C-terminus, compared to isoform 3. Isoform 1 is encoded by transcript variants 1 and 4.
    Source sequence(s)
    AB209288,AI057019,AK025368,BC032784,DA113081
    Consensus CDS
    CCDS3704.1
    UniProtKB/Swiss-Prot
    Q13557
    Conserved Domains (3) summary
    cd00180
    Location:13 – 272
    Blast Score: 783
    S_TKc; Serine/Threonine protein kinases, catalytic domain. Phosphotransferases of the serine or threonine-specific kinase subfamily. The enzymatic activity of these protein kinases is controlled by phosphorylation of specific residues in the activation...
    smart00220
    Location:24 – 272
    Blast Score: 817
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cl09109
    Location:346 – 473
    Blast Score: 607
    NTF2_like; Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...

  4. NM_172127.2 → NP_742125.1  calcium/calmodulin-dependent protein kinase II delta isoform 1

    Description
    Transcript Variant: This variant (1) has multiple differences in the 3' coding region, compared to variant 3. The resulting isoform (1) has a shorter C-terminus, compared to isoform 3. Isoform 1 is encoded by transcript variants 1 and 4.
    Source sequence(s)
    AB209288,AC093900,AI057019,AK025368,DA113081
    Consensus CDS
    CCDS3704.1
    UniProtKB/Swiss-Prot
    Q13557
    Conserved Domains (3) summary
    cd00180
    Location:13 – 272
    Blast Score: 783
    S_TKc; Serine/Threonine protein kinases, catalytic domain. Phosphotransferases of the serine or threonine-specific kinase subfamily. The enzymatic activity of these protein kinases is controlled by phosphorylation of specific residues in the activation...
    smart00220
    Location:24 – 272
    Blast Score: 817
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cl09109
    Location:346 – 473
    Blast Score: 607
    NTF2_like; Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...

  5. NM_172128.2 → NP_742126.1  calcium/calmodulin-dependent protein kinase II delta isoform 2

    Description
    Transcript Variant: This variant (2) lacks an exon in the 3' coding region, compared to variant 3. The resulting isoform (2) has a shorter C-terminus, compared to isoform 3.
    Source sequence(s)
    AB209288,AC093900,AI057019,AK055642,DA113081
    Consensus CDS
    CCDS43263.1
    UniProtKB/TrEMBL
    A8MVS8
    UniProtKB/Swiss-Prot
    Q13557
    Conserved Domains (3) summary
    cd00180
    Location:13 – 272
    Blast Score: 783
    S_TKc; Serine/Threonine protein kinases, catalytic domain. Phosphotransferases of the serine or threonine-specific kinase subfamily. The enzymatic activity of these protein kinases is controlled by phosphorylation of specific residues in the activation...
    smart00220
    Location:24 – 272
    Blast Score: 818
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cl09109
    Location:346 – 473
    Blast Score: 607
    NTF2_like; Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...

  6. NM_172129.1 → NP_742127.1  calcium/calmodulin-dependent protein kinase II delta isoform 4

    Description
    Transcript Variant: This variant (5) has multiple differences in the 3' coding region, compared to variant 3. The resulting isoform (4) has a shorter C-terminus, compared to isoform 3.
    Source sequence(s)
    AB209288,AI057019,AY987011,BC032784,DA113081
    UniProtKB/Swiss-Prot
    Q13557
    Conserved Domains (3) summary
    cd00180
    Location:13 – 272
    Blast Score: 784
    S_TKc; Serine/Threonine protein kinases, catalytic domain. Phosphotransferases of the serine or threonine-specific kinase subfamily. The enzymatic activity of these protein kinases is controlled by phosphorylation of specific residues in the activation...
    smart00220
    Location:24 – 272
    Blast Score: 818
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cl09109
    Location:357 – 484
    Blast Score: 608
    NTF2_like; Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...

RefSeqs of Annotated Genomes: Build 37.1

The following sections contain reference sequences that belong to a specific genome build. Explain

Genome Reference Consortium Human Build 37 (GRCh37), Primary_Assembly

Genomic

  1. NC_000004.11

    Range
    114372187..114683082, complement
    Download
    GenBank FASTA Sequence Viewer (Graphics)

  2. NT_016354.19 

    Range
    38919908..39230803, complement
    Download
    GenBank FASTA Sequence Viewer (Graphics)

Alternate assembly (Celera)

Genomic

  1. AC_000047.1

    Range
    111663867..111974820, complement
    Download
    GenBank FASTA Sequence Viewer (Graphics)

  2. NW_922162.1 

    Range
    61488841..61799794, complement
    Download
    GenBank FASTA Sequence Viewer (Graphics)

Alternate assembly (HuRef)

Genomic

  1. AC_000136.1

    Range
    110100535..110411381, complement
    Download
    GenBank FASTA Sequence Viewer (Graphics)

  2. NW_001838915.1 

    Range
    38862085..39172931, complement
    Download
    GenBank FASTA Sequence Viewer (Graphics)

[Top][Help]Related Sequences

  Nucleotide   Protein
  genomic   AC004056.1   None
  genomic   AC004168.2   None
  genomic   AC093900.3  (144208..150586)   None
  genomic   AC107386.5   None
  genomic   CH471057.1   EAX06295.1
       EAX06296.1
       EAX06297.1
       EAX06298.1
       EAX06299.1
       EAX06300.1
       EAX06301.1
  mRNA   AB209288.1   BAD92525.1
  mRNA   AF071569.1   AAD20442.1
  mRNA   AI004608.1   None
  mRNA   AI057019.1   None
  mRNA   AJ252239.1   CAB65123.1
  mRNA   AK025368.1   None
  mRNA   AK055642.1   BAG51545.1
  mRNA   AK294517.1   BAH11796.1
  mRNA   AL120285.1   None
  mRNA   AY987011.1   AAX88806.1
  mRNA   BC022558.1   AAH22558.1
  mRNA   BC032784.1   AAH32784.1
  mRNA   BX538071.1   None
  mRNA   BX647363.1   None
  mRNA   CA416772.1   None
  mRNA   CF551834.1   None
  mRNA   DA113081.1   None
  mRNA   U50361.1   AAB16866.1
  mRNA   U73738.1   AAB18327.1
  other-genetic   DQ895255.2   ABM86181.1
  other-genetic   EU176241.1   ABW03692.1
Protein Accession   Links
Q13557.3   GenPept   UniProtKB/Swiss-Prot:Q13557
Q4G1A8   GenPept   UniProtKB/TrEMBL:Q4G1A8
Q92991   GenPept   UniProtKB/TrEMBL:Q92991

[Top][Help]Additional Links

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