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1: CAMK2B calcium/calmodulin-dependent protein kinase II beta [ Homo sapiens ]

GeneID: 816 updated 8-Nov-2009

[Top][Help]Summary

Official Symbol
CAMK2Bprovided by HGNC
Official Full Name
calcium/calmodulin-dependent protein kinase II betaprovided by HGNC
Primary Source
HGNC:1461
See related
Ensembl:ENSG00000058404; HPRD:12127; MIM:607707
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CAM2; CAMK2; CAMKB; MGC29528; CAMK2B
Summary
The product of this gene belongs to the serine/threonine protein kinase family and to the Ca(2+)/calmodulin-dependent protein kinase subfamily. Calcium signaling is crucial for several aspects of plasticity at glutamatergic synapses. In mammalian cells, the enzyme is composed of four different chains: alpha, beta, gamma, and delta. The product of this gene is a beta chain. It is possible that distinct isoforms of this chain have different cellular localizations and interact differently with calmodulin. Eight transcript variants encoding eight distinct isoforms have been identified for this gene. [provided by RefSeq]

[Top][Help]Genomic regions, transcripts, and products

(minus strand) Go to reference sequence detailsTry our new Sequence Viewer


[Top][Help]Genomic context

chromosome: 7; Location: 22q12; 7p14.3-p14.1See CAMK2B in MapViewer

[Top][Help]Bibliography

Related Articles in PubMed

GeneRIFs: Gene References Into Function What's a GeneRIF?

PubMed 1. Clinical trial of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)
PubMed 2. Observational study of gene-disease association. (HuGE Navigator)
PubMed 3. These FLIM versions of Camui could be useful for elucidating the function of CaMKII both in vitro and in vivo.
PubMed 4. CaMK II regulates c-FLIP expression and phosphorylation, thus modulating Fas-mediated signaling in glioma cells
PubMed 5. exercise increases the activity of CaMKII in skeletal muscle, suggesting that it may have a role in regulating skeletal muscle function and metabolism during exercise in humans
PubMed 6. measured differences in CaMKII binding affinities for CaM play a minor role in the autophosphorylation of the enzyme, largely dictated by autophosphorylation rate for alpha, beta, gamma and delta isoforms
PubMed 7. thrombomodulin induces Ca2+ signals and nitric oxide synthesis through EGFR and calmodulin kinase II
PubMed 8. regulated degradation of liprinalpha1 is important for proper LAR receptor distribution, and could provide a mechanism for localized control of dendrite and synapse morphogenesis by activity and CaMKII.
PubMed 9. role in cell communication
PubMed 10. the function of CaMK II is essential for PAF-induced macrophage priming, while CaMK IV is not specific for priming by PAF and appears to have a direct link in TLR4-mediated events
PubMed 11. Four distinct isoforms of CAMKII were isolated. Two of them were characterized as CaMKII alpha and beta subunits.expression is developmentally regulated in both human fetal and adult brain to different degrees
PubMed 12. expression significantly elevated in frontal cortex in schizophrenia & depression; because CaMKIIbeta influences expression of neuroreceptors & neural outgrowth & pruning, altered expression in schizophrenia or depression may contribute to these diseases
PubMed 13. presence of a CaMKIIbeta isoform that can target the SR presumably via its membrane anchor alphaKAP defines a previously unrecognized Ca2+/CaM regulatory system in myocardium
PubMed 14. The expression of CaMKII beta was significantly elevated in schizophrenia and in depression.
PubMed 15. mRNA levels are elevated in the frontal cortex in schizophrenia.
Submit: New GeneRIF Correction

[Top][Help]HIV-1 protein interactions

Protein    Interaction
1. Tat HIV-1 Tat inhibits the activation of CAMKII elicited via LFA-1 in NK cells, providing evidence that Tat inhibits NK cell activation which might contribute to the impairment of natural immunity in HIV-1 infection PubMed
2. HIV-1 Tat inhibits the activation of CAMKII elicited via beta (3) integrin PubMed

Go to the HIV-1, Human Protein Interaction Database

[Top][Help]Interactions

Description ..........
  Product Interactant Other Gene Complex Source Pubs          
 
  NP_001211.3   CaMKII inhibitory protein   CAMK2N2      HPRD    PubMed
 
  NP_001211.3   Inositol-trisphosphate 3-kinase A   ITPKA      HPRD    PubMed
CAMK2B (CaMKII-beta) interacts with ACTN4 (alpha-Actinin 4).
  NP_742075.1   NP_004915.2   ACTN4      BIND    PubMed
Two-hybrid
  BioGRID:107266   BioGRID:106596   ACTN4      BioGRID    PubMed
Affinity Capture-MS
  BioGRID:107266   BioGRID:107265   CAMK2A      BioGRID    PubMed

[Top][Help]General gene information

Markers

D7S2140E(e-PCR)
Links: UniSTS:55574
SHGC-32552(e-PCR)
Links: UniSTS:2599
SHGC-79851(e-PCR)
Links: UniSTS:101426
SHGC-172651(e-PCR)
Links: UniSTS:184632
D7S2630(e-PCR)
Links: UniSTS:21580
GDB:1318018(e-PCR)
Links: UniSTS:61935
SHGC-147284(e-PCR)
Links: UniSTS:172785

Homology

Homologs of the CAMK2B gene The CAMK2B gene is conserved in cow, mouse, rat, and zebrafish.


Map Viewer (Mouse, Rat)

Pathways

KEGG pathway: Calcium signaling pathway
04020
KEGG pathway: ErbB signaling pathway
04012
KEGG pathway: Glioma
05214
KEGG pathway: GnRH signaling pathway
04912
KEGG pathway: Long-term potentiation
04720
KEGG pathway: Melanogenesis
04916
KEGG pathway: Neurotrophin signaling pathway
04722
KEGG pathway: Olfactory transduction
04740
KEGG pathway: Wnt signaling pathway
04310
Reactome Event:Synaptic Transmission
REACT_13685

[Top][Help]General protein information

Preferred Names
calcium/calmodulin-dependent protein kinase II beta
Names
calcium/calmodulin-dependent protein kinase II beta
OTTHUMP00000159355
OTTHUMP00000159356
OTTHUMP00000209343
CaM-kinase II beta chain
CaM kinase II beta subunit
proline rich calmodulin-dependent protein kinase
calcium/calmodulin-dependent protein kinase type II beta chain
NP_001211.3
EC 2.7.11.17
3` partial
NP_742075.1
EC 2.7.11.17
3` partial
NP_742076.1
EC 2.7.11.17
3` partial
NP_742077.1
EC 2.7.11.17
3` partial
NP_742078.1
EC 2.7.11.17
3` partial
NP_742079.1
EC 2.7.11.17
3` partial
NP_742080.1
EC 2.7.11.17
3` partial
NP_742081.1
EC 2.7.11.17
3` partial

[Top][Help]NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

mRNA and Protein(s)

  1. NM_001220.4 → NP_001211.3  calcium/calmodulin-dependent protein kinase II beta isoform 1

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
    Source sequence(s)
    AC006454,AK290148,BI550751,U23460
    Consensus CDS
    CCDS5483.1
    UniProtKB/TrEMBL
    A4D2J9
    UniProtKB/TrEMBL
    A4D2K0
    UniProtKB/Swiss-Prot
    Q13554
    Conserved Domains (3) summary
    cd00180
    Location:13 – 272
    Blast Score: 775
    S_TKc; Serine/Threonine protein kinases, catalytic domain. Phosphotransferases of the serine or threonine-specific kinase subfamily. The enzymatic activity of these protein kinases is controlled by phosphorylation of specific residues in the activation...
    smart00220
    Location:24 – 272
    Blast Score: 805
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cl09109
    Location:534 – 661
    Blast Score: 570
    NTF2_like; Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...

  2. NM_172078.2 → NP_742075.1  calcium/calmodulin-dependent protein kinase II beta isoform 2

    Description
    Transcript Variant: This variant (2) lacks an in-frame segment of the coding region, compared to variant 1. It encodes a shorter isoform (2) that is missing an internal segment compared to isoform 1.
    Source sequence(s)
    AC006454,AF078803,AK290148,BI550751
    Consensus CDS
    CCDS5484.1
    UniProtKB/TrEMBL
    A4D2K0
    UniProtKB/Swiss-Prot
    Q13554
    Conserved Domains (3) summary
    cd00180
    Location:13 – 272
    Blast Score: 770
    S_TKc; Serine/Threonine protein kinases, catalytic domain. Phosphotransferases of the serine or threonine-specific kinase subfamily. The enzymatic activity of these protein kinases is controlled by phosphorylation of specific residues in the activation...
    smart00220
    Location:24 – 272
    Blast Score: 798
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cl09109
    Location:410 – 537
    Blast Score: 568
    NTF2_like; Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...

  3. NM_172079.2 → NP_742076.1  calcium/calmodulin-dependent protein kinase II beta isoform 3

    Description
    Transcript Variant: This variant (3), also known as beta 4, lacks an in-frame segment of the coding region, compared to variant 1. It encodes a shorter isoform (3), also known as beta 4 subunit, that is missing an internal segment compared to isoform 1.
    Source sequence(s)
    AC006454,AJ252238,AK290148,BI550751,BX445032,DB566810
    Consensus CDS
    CCDS5485.1
    UniProtKB/TrEMBL
    A4D2K0
    UniProtKB/Swiss-Prot
    Q13554
    Conserved Domains (3) summary
    cd00180
    Location:13 – 272
    Blast Score: 770
    S_TKc; Serine/Threonine protein kinases, catalytic domain. Phosphotransferases of the serine or threonine-specific kinase subfamily. The enzymatic activity of these protein kinases is controlled by phosphorylation of specific residues in the activation...
    smart00220
    Location:24 – 272
    Blast Score: 798
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cl09109
    Location:386 – 513
    Blast Score: 568
    NTF2_like; Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...

  4. NM_172080.2 → NP_742077.1  calcium/calmodulin-dependent protein kinase II beta isoform 4

    Description
    Transcript Variant: This variant (4), also known as beta e, lacks an in-frame segment of the coding region, compared to variant 1. It encodes a shorter isoform (4), also known as beta e subunit, that is missing an internal segment compared to isoform 1.
    Source sequence(s)
    AC006454,AF083419,AK290148,BI550751
    Consensus CDS
    CCDS43573.1
    UniProtKB/TrEMBL
    A4D2K0
    UniProtKB/TrEMBL
    A4D2K5
    UniProtKB/Swiss-Prot
    Q13554
    Conserved Domains (3) summary
    cd00180
    Location:13 – 272
    Blast Score: 769
    S_TKc; Serine/Threonine protein kinases, catalytic domain. Phosphotransferases of the serine or threonine-specific kinase subfamily. The enzymatic activity of these protein kinases is controlled by phosphorylation of specific residues in the activation...
    smart00220
    Location:24 – 272
    Blast Score: 797
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cl09109
    Location:385 – 512
    Blast Score: 568
    NTF2_like; Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...

  5. NM_172081.2 → NP_742078.1  calcium/calmodulin-dependent protein kinase II beta isoform 5

    Description
    Transcript Variant: This variant (5), also known as beta e', lacks an in-frame segment of the coding region, compared to variant 1. It encodes a shorter isoform (5), also known as beta e' subunit, that is missing an internal segment compared to isoform 1.
    Source sequence(s)
    AC006454,AK290148,BC019070,BI550751
    Consensus CDS
    CCDS5486.1
    UniProtKB/TrEMBL
    A4D2K0
    UniProtKB/Swiss-Prot
    Q13554
    Conserved Domains (3) summary
    cd00180
    Location:13 – 272
    Blast Score: 770
    S_TKc; Serine/Threonine protein kinases, catalytic domain. Phosphotransferases of the serine or threonine-specific kinase subfamily. The enzymatic activity of these protein kinases is controlled by phosphorylation of specific residues in the activation...
    smart00220
    Location:24 – 272
    Blast Score: 798
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cl09109
    Location:371 – 498
    Blast Score: 568
    NTF2_like; Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...

  6. NM_172082.2 → NP_742079.1  calcium/calmodulin-dependent protein kinase II beta isoform 6

    Description
    Transcript Variant: This variant (6), also known as beta 6, lacks an in-frame segment of the coding region, compared to variant 1. It encodes a shorter isoform (6), also known as beta 6 subunit, that is missing an internal segment compared to isoform 1.
    Source sequence(s)
    AC006454,AF081924,AK290148,BI550751
    Consensus CDS
    CCDS5487.1
    UniProtKB/TrEMBL
    A4D2K0
    UniProtKB/Swiss-Prot
    Q13554
    Conserved Domains (3) summary
    cd00180
    Location:13 – 272
    Blast Score: 764
    S_TKc; Serine/Threonine protein kinases, catalytic domain. Phosphotransferases of the serine or threonine-specific kinase subfamily. The enzymatic activity of these protein kinases is controlled by phosphorylation of specific residues in the activation...
    smart00220
    Location:24 – 272
    Blast Score: 792
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cl09109
    Location:386 – 487
    Blast Score: 404
    NTF2_like; Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...

  7. NM_172083.2 → NP_742080.1  calcium/calmodulin-dependent protein kinase II beta isoform 7

    Description
    Transcript Variant: This variant (7), also known as beta 2, lacks an in-frame segment of the coding region, compared to variant 1. It encodes a shorter isoform (7), also known as beta 2 subunit, that is missing an internal segment compared to isoform 1.
    Source sequence(s)
    AA399393,AC006454,AJ252236,AK290148,BI550751,DA069361,DB175099
    Consensus CDS
    CCDS5488.1
    UniProtKB/TrEMBL
    A4D2K0
    UniProtKB/Swiss-Prot
    Q13554
    Conserved Domains (3) summary
    cd00180
    Location:13 – 272
    Blast Score: 763
    S_TKc; Serine/Threonine protein kinases, catalytic domain. Phosphotransferases of the serine or threonine-specific kinase subfamily. The enzymatic activity of these protein kinases is controlled by phosphorylation of specific residues in the activation...
    smart00220
    Location:24 – 272
    Blast Score: 791
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cl09109
    Location:347 – 474
    Blast Score: 565
    NTF2_like; Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...

  8. NM_172084.2 → NP_742081.1  calcium/calmodulin-dependent protein kinase II beta isoform 8

    Description
    Transcript Variant: This variant (8), also known as beta 7, lacks an in-frame segment of the coding region, compared to variant 1. It encodes a shorter isoform (8), also known as beta 7 subunit, that is missing an internal segment compared to isoform 1.
    Source sequence(s)
    AC006454,AK290148,BI550751,BX445032,DB566810
    Consensus CDS
    CCDS5489.1
    UniProtKB/TrEMBL
    A4D2K0
    UniProtKB/Swiss-Prot
    Q13554
    Conserved Domains (3) summary
    cd00180
    Location:13 – 272
    Blast Score: 759
    S_TKc; Serine/Threonine protein kinases, catalytic domain. Phosphotransferases of the serine or threonine-specific kinase subfamily. The enzymatic activity of these protein kinases is controlled by phosphorylation of specific residues in the activation...
    smart00220
    Location:24 – 272
    Blast Score: 787
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cl09109
    Location:317 – 444
    Blast Score: 564
    NTF2_like; Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...

RefSeqs of Annotated Genomes: Build 37.1

The following sections contain reference sequences that belong to a specific genome build. Explain

Genome Reference Consortium Human Build 37 (GRCh37), Primary_Assembly

Genomic

  1. NC_000007.13

    Range
    44256748..44365229, complement
    Download
    GenBank FASTA Sequence Viewer (Graphics)

  2. NT_007819.17 

    Range
    44246748..44355229, complement
    Download
    GenBank FASTA Sequence Viewer (Graphics)

Alternate assembly (Celera)

Genomic

  1. AC_000050.1

    Range
    44354714..44422312, complement
    Download
    GenBank FASTA Sequence Viewer (Graphics)

  2. NW_923273.1 

    Range
    179364..246962, complement
    Download
    GenBank FASTA Sequence Viewer (Graphics)

Alternate assembly (HuRef)

Genomic

  1. AC_000139.1

    Range
    44142027..44208378, complement
    Download
    GenBank FASTA Sequence Viewer (Graphics)

  2. NW_001839004.1 

    Range
    4957949..5024300, complement
    Download
    GenBank FASTA Sequence Viewer (Graphics)

Alternate assembly (CRA_TCAGchr7v2)

Genomic

  1. AC_000068.1

    Range
    44296254..44404748, complement
    Download
    GenBank FASTA Sequence Viewer (Graphics)

  2. NT_079592.2 

    Range
    44246254..44354748, complement
    Download
    GenBank FASTA Sequence Viewer (Graphics)

[Top][Help]Related Sequences

  Nucleotide   Protein
  genomic   AC006454.4  (2000..33308)   None
  genomic   AC093086.4   AAS07454.1
  genomic   AC106040.3   AAS02024.1
  genomic   CH236960.1   EAL23755.1
       EAL23756.1
       EAL23757.1
       EAL23758.1
       EAL23759.1
       EAL23760.1
       EAL23761.1
       EAL23762.1
  genomic   CH471128.2   EAW61104.1
       EAW61105.1
       EAW61106.1
       EAW61107.1
       EAW61108.1
       EAW61109.1
  mRNA   AA399393.1   None
  mRNA   AB073352.1   None
  mRNA   AF078803.1   AAD42035.1
  mRNA   AF081572.1   AAD42036.1
  mRNA   AF081924.1   AAD42037.1
  mRNA   AF083419.1   AAD42038.1
  mRNA   AF112471.1   AAD03743.1
  mRNA   AF112472.1   AAD03744.1
  mRNA   AF131776.1   None
  mRNA   AF140350.1   AAD42070.1
  mRNA   AI190315.1   None
  mRNA   AJ252236.1   CAB65120.1
  mRNA   AJ252237.1   CAB65121.1
  mRNA   AJ252238.1   CAB65122.1
  mRNA   AK091991.1   None
  mRNA   AK222703.1   BAD96423.1
  mRNA   AK290148.1   BAF82837.1
  mRNA   AK294138.1   BAH11682.1
  mRNA   AK315663.1   BAG38029.1
  mRNA   BC019070.2   AAH19070.1
  mRNA   BI550751.1   None
  mRNA   BX445032.2   None
  mRNA   CR602217.1   None
  mRNA   CR602724.1   None
  mRNA   CR617994.1   None
  mRNA   CR622698.1   None
  mRNA   DA069361.1   None
  mRNA   DB175099.1   None
  mRNA   DB566810.1   None
  mRNA   U23460.1   AAC99802.1
  mRNA   U50358.1   AAB16863.1
  other-genetic   AM392749.1   CAL37627.1
  other-genetic   AM392792.1   CAL37670.1
  other-genetic   AM393562.1   CAL38439.1
  other-genetic   AM393817.1   CAL38692.1
Protein Accession   Links
Q13554.2   GenPept   UniProtKB/Swiss-Prot:Q13554
Q53H78   GenPept   UniProtKB/TrEMBL:Q53H78
Q75KE9   GenPept   UniProtKB/TrEMBL:Q75KE9
Q75LA8   GenPept   UniProtKB/TrEMBL:Q75LA8

[Top][Help]Additional Links