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1: CAMK4 calcium/calmodulin-dependent protein kinase IV [ Homo sapiens ]

GeneID: 814 updated 16-Oct-2009

[Top][Help]Summary

Official Symbol
CAMK4provided by HGNC
Official Full Name
calcium/calmodulin-dependent protein kinase IVprovided by HGNC
Primary Source
HGNC:1464
See related
Ensembl:ENSG00000152495; HPRD:07169; MIM:114080
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CaMK-GR; MGC36771; CAMK4
Summary
The product of this gene belongs to the serine/threonine protein kinase family, and to the Ca(2+)/calmodulin-dependent protein kinase subfamily. This enzyme is a multifunctional serine/threonine protein kinase with limited tissue distribution, that has been implicated in transcriptional regulation in lymphocytes, neurons and male germ cells. [provided by RefSeq]

[Top][Help]Genomic regions, transcripts, and products

(plus) Go to reference sequence detailsTry our new Sequence Viewer


[Top][Help]Genomic context

chromosome: 5; Location: 5q21.3See CAMK4 in MapViewer

[Top][Help]Bibliography

Related Articles in PubMed

GeneRIFs: Gene References Into Function What's a GeneRIF?

PubMed 1. analysis of regulation of calcium/calmodulin-dependent kinase IV by O-GlcNAc modification
PubMed 2. CaMKIV is a molecular link between Group I mGluRs and fragile X mental retardation protein in anterior cingulate cortex neurons
PubMed 3. a group of RNA elements are responsive to PKA and CaMKIV from in vivo selection
PubMed 4. these data indicate that the B subunits alpha and delta are essential for the interaction of PP2A with CaMKIV.
PubMed 5. hnRNP L is an essential component of CaMKIV-regulated alternative splicing through CA repeats, with its phosphorylation likely playing a critical role.
PubMed 6. CaMKIV plays a critical role in the development and persistence of cocaine-induced behaviors, through mechanisms dissociated from acute effects on gene expression and CREB-dependent transcription.
PubMed 7. CaMK-4 expression correlates positively with the ability to form long-term memory and implicates the decline of CaMKIV signaling mechanisms in age-related memory deficits.
PubMed 8. Observational study of gene-disease association. (HuGE Navigator)
PubMed 9. Transgenic CaMKIV plays a modulatory role in the nucleus accumbens in anxiety-like behavior of adult CaMKIV variant mice.
PubMed 10. a novel link between TLR4 and a calcium-dependent signaling cascade comprising CaMKIV-CREB-Bcl-2 that is essential for DC survival.
PubMed 11. sequestration of CaMKK may be the molecular mechanism by which catalytically inactive mutants of CaMKIV exert their "dominant-negative" functions within the cell
PubMed 12. calcium/CaMKIV signaling pathway may play an important role in the excitation-mediated regulation of corticotropin releasing hormone synthesis
PubMed 13. CaMKIV proteins were found in the nucleus of epithelial ovarian cancer tissue. CaMKIV expression was significantly associated with clinical stage (P<0.01), histological grade (P<0.01), and clinical outcome (P<0.01).
PubMed 14. the function of CaMK II is essential for PAF-induced macrophage priming, while CaMK IV is not specific for priming by PAF and appears to have a direct link in TLR4-mediated events
PubMed 15. Results identify calcium/calmodulin-dependent kinase IV as being responsible for the increased expression of CREM and the decreased production of interleukin-2 in systemic lupus erythematosus T cells.
PubMed 16. the Ca(2+)/CaM binding-autoinhibitory domain of CaMKIV is required for association of the kinase with PP2A
PubMed 17. CaMKIV is expressed in human sperm and may have a role in the regulation of human sperm motility
Submit: New GeneRIF Correction

[Top][Help]Interactions

Description ..........
  Product Interactant Other Gene Complex Source Pubs          
 
  Calcium/calmodulin dependent protein kinase IV   NP_757344.1   CAMKK1      HPRD    PubMed
CAMK4 (CAMKIV) interacts with CABIN1.
  NP_001735.1   NP_036427.1   CABIN1      BIND    PubMed
 
  NP_001735.1   NP_006540.3   CAMKK2      HPRD    PubMed

[Top][Help]General gene information

Markers

RH11450(e-PCR)
Links: UniSTS:2102
SHGC-141749(e-PCR)
Links: UniSTS:171063
D5S2448(e-PCR)
Links: UniSTS:11079
CAMK4_8239(e-PCR)
Links: UniSTS:467592
RH36499(e-PCR)
Links: UniSTS:77203
RH69019(e-PCR)
Links: UniSTS:45210
RH36049(e-PCR)
Links: UniSTS:1953
RH121498(e-PCR)
Links: UniSTS:134624
SHGC-104500(e-PCR)
Links: UniSTS:168936
SGC35247(e-PCR)
Links: UniSTS:60137
D5S1778(e-PCR)
Links: UniSTS:153590
D5S1780(e-PCR)
Links: UniSTS:153592
D5S1785(e-PCR)
Links: UniSTS:153597

Phenotypes

Framingham Heart Study 100K Project: genome-wide associations for blood pressure and arterial stiffness
NHGRI GWA Catalog

Homology

Homologs of the CAMK4 gene The CAMK4 gene is conserved in chimpanzee, mouse, rat, chicken, zebrafish, and A.thaliana.


Map Viewer (Mouse, Rat)

Pathways

KEGG pathway: Calcium signaling pathway
04020
KEGG pathway: Long-term potentiation
04720
KEGG pathway: Neurotrophin signaling pathway
04722
Reactome Event:Opioid Signalling
REACT_15295
Reactome Event:Signalling by NGF
REACT_11061

[Top][Help]General protein information

Preferred Names
calcium/calmodulin-dependent protein kinase IV
Names
calcium/calmodulin-dependent protein kinase IV
CAM kinase IV
CAM kinase- GR
brain Ca++-calmodulin-dependent protein kinase type IV
brain Ca(2+)-calmodulin-dependent protein kinase type IV
calcium/calmodulin-dependent protein kinase type IV catalytic chain
NP_001735.1
EC 2.7.11.17

[Top][Help]NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

mRNA and Protein(s)

  1. NM_001744.3 → NP_001735.1  calcium/calmodulin-dependent protein kinase IV

    Source sequence(s)
    BC025687,BG721313
    Consensus CDS
    CCDS4103.1
    UniProtKB/Swiss-Prot
    Q16566
    Conserved Domains (2) summary
    cd00180
    Location:46 – 300
    Blast Score: 748
    S_TKc; Serine/Threonine protein kinases, catalytic domain. Phosphotransferases of the serine or threonine-specific kinase subfamily. The enzymatic activity of these protein kinases is controlled by phosphorylation of specific residues in the activation...
    smart00220
    Location:56 – 300
    Blast Score: 819
    S_TKc; Serine/Threonine protein kinases, catalytic domain

RefSeqs of Annotated Genomes: Build 37.1

The following sections contain reference sequences that belong to a specific genome build. Explain

Genome Reference Consortium Human Build 37 (GRCh37), Primary_Assembly

Genomic

  1. NC_000005.9

    Range
    110560081..110820748
    Download
    GenBank FASTA Sequence Viewer (Graphics)

  2. NT_034772.6 

    Range
    18873953..19134620
    Download
    GenBank FASTA Sequence Viewer (Graphics)

Alternate assembly (Celera)

Genomic

  1. AC_000048.1

    Range
    106506011..106766349
    Download
    GenBank FASTA Sequence Viewer (Graphics)

  2. NW_922751.1 

    Range
    11127182..11387520
    Download
    GenBank FASTA Sequence Viewer (Graphics)

Alternate assembly (HuRef)

Genomic

  1. AC_000137.1

    Range
    105739135..105999500, complement
    Download
    GenBank FASTA Sequence Viewer (Graphics)

  2. NW_001838952.2 

    Range
    27977207..28237572, complement
    Download
    GenBank FASTA Sequence Viewer (Graphics)

[Top][Help]Related Sequences

  Nucleotide   Protein
  genomic   AC010275.6  (21859..197254)   None
  genomic   AC010468.5   None
  genomic   AC011422.2  (41263..82815)   None
  genomic   CH471086.2   EAW49032.1
       EAW49033.1
       EAW49034.1
  mRNA   AK311662.1   None
  mRNA   AK312840.1   BAG35694.1
  mRNA   AL833368.1   None
  mRNA   BC016695.1   AAH16695.2
  mRNA   BC025687.1   AAH25687.1
  mRNA   BG721313.1   None
  mRNA   CR615443.1   None
  mRNA   CR622299.1   None
  mRNA   D30742.1   BAA06403.1
  mRNA   L17000.1   AAA35639.1
  mRNA   L24959.1   AAA18251.1
  other-genetic   DQ892902.2   ABM83828.1
  other-genetic   DQ893195.2   ABM84121.1
  other-genetic   DQ893196.2   ABM84122.1
  other-genetic   DQ896523.2   ABM87522.1
  other-genetic   DQ896524.2   ABM87523.1
  other-genetic   DQ896525.2   ABM87524.1
  other-genetic   DQ896526.2   ABM87525.1
Protein Accession   Links
Q16566.1   GenPept   UniProtKB/Swiss-Prot:Q16566

[Top][Help]Additional Links