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1. |
Data suggest that the state of tau3 phosphorylation by protein kinase A affects the mode of 14-3-3zeta binding and by this means might modify tau filament formation. |
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14-3-3zeta cooperates with ErbB2 to promote ductal carcinoma in situ progression to invasive breast cancer by inducing epithelial-mesenchymal transition. |
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3. |
14-3-3zeta mediates resistance of diffuse large B cell lymphoma to an anthracycline-based chemotherapeutic regimen |
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4. |
study presents the cellular translocation of 14-3-3 zeta in JC virus(JCV) nonsusceptible progenitors and JCV-susceptible progenitor-derived astrocytes; results suggest that the nuclear presence of 14-3-3 zeta may play a role in JCV infection |
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5. |
An integrin-alpha4-14-3-3zeta-paxillin ternary complex mediates localised Cdc42 activity and accelerates cell migration. |
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6. |
14-3-3z:Shc scaffolds can act as multivalent signaling nodes for the integration of both phosphoserine/threonine and phosphotyrosine pathways to regulate specific cellular responses. |
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7. |
changes in the expression of five 14-3-3 isoforms (beta, gamma, epsilon, tau, and zeta) during the apoptosis of JURL-MK1 and K562 cells. |
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8. |
These results implicate 14-3-3zeta/tau heterodimers as key regulators of SSH1 activity in keratinocytes and suggest they play a role in cytoskeleton remodeling during cell migration. |
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9. |
Observational study of gene-disease association. (HuGE Navigator) |
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10. |
The authors report that phosphorylation leads to the unfolding of the structurally atypical and unstable KH1, creating a site for 14-3-3zeta binding. |
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11. |
Phosphorylation by cAMP-dependent protein kinase strongly enhanced interaction of tau3 with 14-3-3. |
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12. |
Immunofluorescent staining for 14-3-3 zeta demonstrated expression of the protein on ascitic and peritumoral macrophages in epithelial ovarian carcinoma patients |
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13. |
This protein has been found differentially expressed in the temporal lobe from patients with schizophrenia. |
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14. |
PKC delta in preeclamptic placentas promotes Bax dissociation from 14-3-3 zeta through 14-3-3 zeta phosphorylation. |
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15. |
structure & properties of wild type 14-3-3zeta & point mutants S58E, S184E, T232E & mutant S58E/S184E/T232E mimicking phosphorylation; mutation mimicking phosphorylation of Ser58 destabilized & mutation of Ser184 induced stabilization of 14-3-3zeta |
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16. |
14-3-3epsilon and 14-3-3zeta are identified as Cby-binding partners. |
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17. |
combined gene effects between 14-3-3 zeta (intron 4, rs 983583) polymorphism and tau (intron 9, rs 2471738) polymorphism might be responsible for susceptibility to Alzheimer disease |
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18. |
Our data support a novel role for 14-3-3zeta in the aggregate formation of nonnative, aggregation-prone proteins. |
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19. |
14-3-3 zeta protein and butyrylcholinesterase (BCHE) synergistic effects between polymorphisms in tau phosphorylation relate-genes may help in determining the risk profile for AD. |
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20. |
Observational study of gene-disease association and gene-gene interaction. (HuGE Navigator) |
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21. |
Knockdown of 14-3-3 zeta induces at least two isoform-specific phenotypes that are consistent with potential oncogenic activity during tumorigenesis. |
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22. |
14-3-3zeta has a critical role in anoikis suppression in lung cancer cells |
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23. |
findings suggest that over-expression of 14-3-3zeta is an early event in oral tumorigenesis and may have an important role in its development and progression |
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24. |
14-3-3zeta is a granule protein related to atherosclerosis |
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25. |
Identification of 14-3-3zeta as a protein kinase B/Akt substrate. |
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26. |
role for the 14-3-3zeta/ADAM 22 association in the regulation of cell adhesion and related signaling events |
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27. |
binds cofilin and LIM-domain-containing protein kinase 1 |
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28. |
14-3-3zeta has a role in MAPKAPK2-mediated phosphorylation, which may represent a novel pathway mediating p38 MAPK-dependent inflammation |
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29. |
14-3-3zeta is a specific substrate for YSK1 that localizes to the Golgi apparatus, and potentially links YSK1 signaling at the Golgi apparatus with protein transport. |
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30. |
within the tau phosphorylation complex, 14-3-3 connects Ser(9)-phosphorylated GSK3beta to tau and Ser(9)-phosphorylated GSK3beta phosphorylates tau |
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31. |
Our data demonstrate that 14-3-3zeta mediates tau phosphorylation by Ser9-phosphorylated GSK3beta in HEK-293 cells. |
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32. |
existence of a second major 14-3-3zeta binding site within the cytoplasmic tail of GPIbalpha that has an important functional role in regulating integrin-dependent cell spreading. |
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33. |
YWHAZ gene is a susceptibility gene for paranoid schizophrenia |
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34. |
TSC2 associates with 14-3-3 in vivo |
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35. |
Zeta 14-3-3 protein facilitates tau assembly into fibrillar polymers, with polymerization reduced but not abolished, when tau is modified by protein kinase A. |
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36. |
EGF-induced co-localization of mouse EGFR and human 14-3-3zeta along the plasma membrane. |
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37. |
In the presence of 14-3-3, the requirement of two phosphorylated 14-3-3 zeta binding motifs for the complete inhibition of FOXO4 binding to its target DNA is demonstrated. |
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38. |
14-3-3 binds to protein C-terminal domains |
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39. |
FRET analysis of 14-3-3 protein C-terminal stretch |
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40. |
14-3-3 zeta binds with tuberin to regulate phosphorylation of ribosomal protein S6 |
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41. |
a 14-3-3 zeta implication in the Alzheimer's neuropathology |
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42. |
binding of 14-3-3 to Par3beta is dependent on phosphorylation |
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43. |
Alpha-synuclein, a small presynaptic protein implicated in Parkinson's disease and other neurodegenerative disorders, interacts with 14-3-3 and both proteins appear to differentially regulate the activities of important cellular enzymes. |
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44. |
Vpr interferes with the suppressive effects of insulin on FOXO-mediated transcription of target genes via 14-3-3. (14-3-3 Protein) |