- Official
Symbol
- YWHAHprovided by HGNC
- Official
Full Name
- tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, eta polypeptideprovided by HGNC
- Primary Source
-
HGNC:12853
- Locus Tag
- LL22NC03-44A4.1
- See related
-
Ensembl:ENSG00000128245;
HPRD:00215;
MIM:113508
- Gene type
- protein coding
- RefSeq status
- REVIEWED
- Organism
-
Homo sapiens
- Lineage
- Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
- Also known as
- YWHA1; YWHAH
- Summary
- This gene product belongs to the 14-3-3 family of proteins which mediate signal transduction by binding to phosphoserine-containing proteins. This highly conserved protein family is found in both plants and mammals, and this protein is 99% identical to the mouse, rat and bovine orthologs. This gene contains a 7 bp repeat sequence in its 5' UTR, and changes in the number of this repeat have been associated with early-onset schizophrenia and psychotic bipolar disorder. [provided by RefSeq]
chromosome: 22; Location: 22q12.3See
YWHAH
in MapViewer
Related Articles in PubMed
GeneRIFs: Gene References Into Function
What's a GeneRIF?
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1. |
This protein has been found differentially expressed in the temporal lobe from patients with schizophrenia. |
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2. |
Observational study of gene-disease association. (HuGE Navigator) |
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3. |
Detection of only 2 (14-3-3 eta and gamma) out of 7 different isoforms in synovial fluid suggests they are specific to the site of joint inflammation |
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4. |
Data demonstrate that 14-3-3 proteins are colocalized with Lewy bodies in Parkinson disease, but there was no specific staining for the 14-3-3 eta subunit. |
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5. |
gremlin 1 is overexpressed in human cancers and interacts with YWHAH protein |
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6. |
Results show that three 14-3-3 isoforms, beta, gamma and eta, are DAL-1/Protein 4.1B-binding proteins. |
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7. |
phosphorylation of 14-3-3 binding site of myeloid leukemia factor 1 by MADM |
| |
| 1. Vpr |
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HIV-1 Vpr forms a triple complex with 14-3-3 eta and Cdc25C and thereby promotes cell cycle arrest at the G(2)/M phase by facilitating association of 14-3-3 and Cdc25C |
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PubMed
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|
| 2. |
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HIV-1 Vpr inhibits insulin-induced association of 14-3-3 and Foxo3a in HeLa cells |
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PubMed
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| 3. |
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Yeast two-hybrid assays show that HIV-1 Vpr binds strongly to 14-3-3 eta amino acids 141 to 244; the smallest 14-3-3 eta fragment (residues 190-210) also supports this binding, and amino acid mutation R80A in Vpr abolishes the binding to 14-3-3 eta |
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PubMed
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|
| 4. |
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Interaction of HIV-1 Vpr with human 14-3-3 protein is presumed based on homology to yeast DNA damage checkpoint protein rad25 which enhances HIV-1 Vpr-induced G2 arrest in vitro, most likely through the inhibition of Cdc25 |
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PubMed
|
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Go to the HIV-1, Human
Protein Interaction Database
Pathways
- KEGG pathway: Cell cycle
- 04110
- KEGG pathway: Neurotrophin signaling pathway
- 04722
Gene Ontology Provided by GOA
- Preferred Names
- tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, eta polypeptide
- Names
- tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, eta polypeptide
- 14-3-3 eta
RefSeqs maintained independently of Annotated Genomes
These reference sequences exist independently of genome builds. Explain
These reference sequences are curated
independently of the genome annotation cycle, so their versions may not match the RefSeq
versions in the current genome build. Identify version mismatches by comparing the
version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products
above.
mRNA and Protein(s)
-
NM_003405.3 → NP_003396.1 tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, eta polypeptide
- Source sequence(s)
-
AY007132,BC003047,Z82248
- Consensus CDS
-
CCDS13901.1
- UniProtKB/Swiss-Prot
-
Q04917
- UniProtKB/TrEMBL
-
Q9H4N8
- Conserved Domains (1) summary
-
- cl02098
Location:4 – 241
Blast Score: 1082
- 14-3-3; 14-3-3 protein
RefSeqs of Annotated Genomes: Build 37.1
The following sections contain reference sequences that belong to a
specific genome build. Explain
This section includes genomic Reference
Sequences (RefSeqs) from all assemblies on which this gene is annotated, such as RefSeqs
for chromosomes and scaffolds (contigs) from both reference and alternate assemblies.
Model RNAs and proteins are also reported here.
Genome Reference Consortium Human Build 37 (GRCh37), Primary_Assembly
Genomic
-
NC_000022.10
- Range
- 32340478..32353589
- Download
-
GenBank
FASTA
Sequence Viewer (Graphics)
-
NT_011520.12
- Range
- 11731047..11744158
- Download
-
GenBank
FASTA
Sequence Viewer (Graphics)
Alternate assembly (Celera)
Genomic
-
AC_000065.1
- Range
- 16140926..16154031
- Download
-
GenBank
FASTA
Sequence Viewer (Graphics)
-
NW_927628.1
- Range
- 10407120..10420225
- Download
-
GenBank
FASTA
Sequence Viewer (Graphics)
Alternate assembly (HuRef)
Genomic
-
AC_000154.1
- Range
- 15296793..15309901
- Download
-
GenBank
FASTA
Sequence Viewer (Graphics)
-
NW_001838745.1
- Range
- 10423926..10437034
- Download
-
GenBank
FASTA
Sequence Viewer (Graphics)
Gene LinkOut
The following LinkOut resources are supplied by external providers. These providers are
responsible for maintaining the links.
- Molecular Biology Databases
- Research Materials
NITE Biological Resource Center- antibodies-online
- ExactAntigen