1: YWHAG tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma polypeptide [ Homo sapiens ]

GeneID: 7532 updated 8-Nov-2009

[Top][Help]Summary

Official Symbol
YWHAGprovided by HGNC
Official Full Name
tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma polypeptideprovided by HGNC
Primary Source
HGNC:12852
See related
Ensembl:ENSG00000170027; HPRD:05639; MIM:605356
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
14-3-3GAMMA; YWHAG
Summary
This gene product belongs to the 14-3-3 family of proteins which mediate signal transduction by binding to phosphoserine-containing proteins. This highly conserved protein family is found in both plants and mammals, and this protein is 100% identical to the rat ortholog. It is induced by growth factors in human vascular smooth muscle cells, and is also highly expressed in skeletal and heart muscles, suggesting an important role for this protein in muscle tissue. It has been shown to interact with RAF1 and protein kinase C, proteins involved in various signal transduction pathways. [provided by RefSeq]

[Top][Help]Genomic regions, transcripts, and products

(minus strand) Go to reference sequence detailsTry our new Sequence Viewer


[Top][Help]Bibliography

Related Articles in PubMed

GeneRIFs: Gene References Into Function What's a GeneRIF?

PubMed 1. changes in the expression of five 14-3-3 isoforms (beta, gamma, epsilon, tau, and zeta) during the apoptosis of JURL-MK1 and K562 cells.
PubMed 2. These results suggest that the override of checkpoint observed in 14-3-3gamma knockdown cells is due to failure to inhibit cdc25C function.
PubMed 3. This protein has been found differentially expressed in the temporal lobe from patients with schizophrenia.
PubMed 4. Report reduced expression of 14-3-3 gamma in uterine leiomyoma as identified by proteomics.
PubMed 5. human 14-3-3gamma binds to the ERK1/2 molecular scaffold KSR1, which is mediated by the C-terminal stretch of 14-3-3gamma
PubMed 6. Both single marker and haplotype analyses were negative for the Ywhag gene association with smoking initiation and nicotine dependence.
PubMed 7. Detection of only 2 (14-3-3 eta and gamma) out of 7 different isoforms in synovial fluid suggests they are specific to the site of joint inflammation
PubMed 8. our data indicate that 14-3-3gamma may contribute to tumorigenesis by promoting genomic instability.
PubMed 9. Interaction of human 14-3-3gamma with the small heat shock protein Hsp20 was analyzed by means of size-exclusion chromatography and chemical crosslinking.
PubMed 10. 14-3-3 suppresses importin alpha/beta-dependent nuclear localization of Thr157-phosphorylated p27, suggesting implications for cell cycle disorder in Akt-activated cancer cells.
PubMed 11. 14-3-3 binds to the IGF-1 receptor after IGF1R's serine autophosphorylation
PubMed 12. TSC2 associates with 14-3-3 in vivo
PubMed 13. Results show that three 14-3-3 isoforms, beta, gamma and eta, are DAL-1/Protein 4.1B-binding proteins.
PubMed 14. multiple interactions of AICD with FE65 and 14-3-3gamma modulate FE65-dependent gene transactivation
PubMed 15. Aberrant expression of signaling-related proteins 14-3-3 gamma and RACK1 in fetal Down syndrome brain (trisomy 21).

[Top][Help]HIV-1 protein interactions

Protein    Interaction
1. Vpr HIV-1 Vpr inhibits insulin-induced association of 14-3-3 and Foxo3a in HeLa cells PubMed
2. Interaction of HIV-1 Vpr with human 14-3-3 protein is presumed based on homology to yeast DNA damage checkpoint protein rad25 which enhances HIV-1 Vpr-induced G2 arrest in vitro, most likely through the inhibition of Cdc25 PubMed

Go to the HIV-1, Human Protein Interaction Database

[Top][Help]Interactions

Description ..........
  Product Interactant Other Gene Complex Source Pubs          
 
  NP_036611.2   NP_006729.4   AKAP13      HPRD    PubMed
 
  NP_036611.2   NP_056060.1   ANKS1A      HPRD    PubMed
 
  NP_036611.2   AAL96658.1   ARHGEF2      HPRD    PubMed
 
  NP_036611.2   NP_004037.1   ATP5A1      HPRD    PubMed
 
  NP_036611.2   NP_055554.1   BCLAF1      HPRD    PubMed
 
  NP_036611.2   NP_000061.1   CAPN3      HPRD    PubMed
CDK11-p110 interacts with 14-3-3-gamma.
  NP_036611.2   AAA19586.1   CDC2L1      BIND    PubMed
 
  NP_036611.2   NP_065821.1   CGN      HPRD    PubMed
 
  NP_036611.2   NP_003984.1   CLK2      HPRD    PubMed
 
  NP_036611.2   NP_003983.1   CLK3      HPRD    PubMed
 
  NP_036611.2   NP_859066.1   CRTC2      HPRD    PubMed
 
  NP_036611.2   NP_001307.2   CSE1L      HPRD    PubMed
 
  NP_036611.2   NP_004392.1   DFFA      HPRD    PubMed
 
  NP_036611.2   DISC1   DISC1      HPRD    PubMed
 
  NP_036611.2   NP_212132.2   DOCK7      HPRD    PubMed
 
  NP_036611.2   NP_001387.2   DYRK1A      HPRD    PubMed
 
  NP_036611.2   NP_001395.1   EEF1G      HPRD    PubMed
 
  NP_036611.2   NP_036439.2   EPB41L3      HPRD    PubMed
 
  NP_036611.2   NP_055879.1   ERC1      HPRD    PubMed
 
  NP_036611.2   NP_055623.1   FARP2      HPRD    PubMed
 
  NP_036611.2   FKHR   FOXO1      HPRD    PubMed
 
  NP_036611.2   NP_689543.1   FRMD6      HPRD    PubMed
 
  NP_036611.2   NP_055889.1   KIF1B      HPRD    PubMed
 
  NP_036611.2   NP_006603.1   KIF1C      HPRD    PubMed
 
  NP_036611.2   NP_612565.1   KIF23      HPRD    PubMed
 
  NP_036611.2   NP_803136.1   KLC3      HPRD    PubMed
 
  NP_036611.2   Keratin 18   KRT18      HPRD    PubMed
 
  NP_036611.2   NP_056130.2   LARP1      HPRD    PubMed
 
  NP_036611.2   NP_991403.1   LSR      HPRD    PubMed
 
  NP_036611.2   NP_057103.1   LUC7L2      HPRD    PubMed
 
  NP_036611.2   NP_057508.2   LUC7L3      HPRD    PubMed
 
  NP_036611.2   NP_006600.2   MAP3K2      HPRD    PubMed
 
  NP_036611.2   NP_203744.1   MICALL1      HPRD    PubMed
 
  NP_036611.2   NP_055949.2   MPRIP      HPRD    PubMed
 
  NP_036611.2   NP_055872.1   MYCBP2      HPRD    PubMed
 
  NP_036611.2   NP_689739.3   PARD3B      HPRD    PubMed
 
  NP_036611.2   NP_006192.1   PCTK1      HPRD    PubMed
 
  NP_036611.2   NP_002642.1   PI4KB      HPRD    PubMed
 
  NP_036611.2   AAB48304.1   PNN      HPRD    PubMed
 
  NP_036611.2   NP_004783.2   PPIG      HPRD    PubMed
 
  NP_036611.2   NP_002728.1   PRKCA      HPRD    PubMed
 
  NP_036611.2   NP_002729.2   PRKCB      HPRD    PubMed
 
  NP_036611.2   NP_006245.1   PRKCD      HPRD    PubMed
 
  NP_036611.2   NP_002730.1   PRKCG      HPRD    PubMed
 
  NP_036611.2   NP_006248.1   PRKCQ      HPRD    PubMed
 
  NP_036611.2   NP_055317.1   PRPF19      HPRD    PubMed
 
  NP_036611.2   AAH27178.1   PRPF40A      HPRD    PubMed
 
  NP_036611.2   NP_055719.1   RAB11FIP2      HPRD    PubMed
 
  NP_036611.2   BAC87138.1   RABGEF1      HPRD    PubMed
 
  NP_036611.2   NP_002871.1   RAF1      HPRD    PubMed
 
  NP_036611.2   NP_689876.2   RALGPS2      HPRD    PubMed
 
  NP_036611.2   NP_733793.1   RASAL2      HPRD    PubMed
 
  NP_036611.2   NP_056404.1   SAMD4A      HPRD    PubMed
 
  NP_036611.2   NP_060498.2   SAMD4B      HPRD    PubMed
 
  NP_036611.2   NP_036558.3   SF3B3      HPRD    PubMed
 
  NP_036611.2   NP_085148.1   SH3BP5L      HPRD    PubMed
 
  NP_036611.2   NP_079021.2   SHCBP1      HPRD    PubMed
 
  NP_036611.2   NP_061881.2   SMCR7L      HPRD    PubMed
 
  NP_036611.2   NP_620305.1   SON      HPRD    PubMed
 
  NP_036611.2   c-Src   SRC      HPRD    PubMed
 
  NP_036611.2   NP_003128.3   SRPK1      HPRD    PubMed
 
  NP_036611.2   NP_005830.2   SRRM1      HPRD    PubMed
 
  NP_036611.2   NP_055988.2   TBC1D1      HPRD    PubMed
 
  NP_036611.2   NP_004808.2   TJP2      HPRD    PubMed
 
  NP_036611.2   Zinc finger protein A20   TNFAIP3      HPRD    PubMed
Hamartin interacts with 14-3-3-gamma. This interaction is modeled on demonstrated interaction between human hamartin and mouse 14-3-3-gamma isoform.
  NP_036611.2   NP_000359.1   TSC1      BIND    PubMed
 
  NP_036611.2   NP_000539.1   TSC2      HPRD    PubMed
The tumor suppressor protein tuberin interacts with 14-3-3-gamma isoform. This interaction is modeled on demonstrated interaction between human tuberin and mouse 14-3-3-gamma.
  NP_036611.2   NP_000539.1   TSC2      BIND    PubMed
UCP2 interacts with 14.3.3-gamma.
  NP_036611.2   NP_003346.2   UCP2      BIND    PubMed
UCP3 interacts with 14.3.3-gamma.
  NP_036611.2   NP_003347.1   UCP3      BIND    PubMed
 
  NP_036611.2   NP_003398.1   ZFP36      HPRD    PubMed
 
  NP_036611.2   NP_065778.2   ZNF295      HPRD    PubMed
Affinity Capture-MS
  BioGRID:113364   BioGRID:116889   ANKS1A      BioGRID    PubMed
Affinity Capture-MS
  BioGRID:113364   BioGRID:106864   ARAF      BioGRID    PubMed
Affinity Capture-MS
  BioGRID:113364   BioGRID:115721   BAIAP2      BioGRID    PubMed
Affinity Capture-MS
  BioGRID:113364   BioGRID:107141   BRAF      BioGRID    PubMed
Affinity Capture-MS
  BioGRID:113364   BioGRID:116904   C22orf9      BioGRID    PubMed
Affinity Capture-MS
  BioGRID:113364   BioGRID:121589   CGN      BioGRID    PubMed
Affinity Capture-MS
  BioGRID:113364   BioGRID:116919   CLASP1      BioGRID    PubMed
Affinity Capture-MS
  BioGRID:113364   BioGRID:128308   CRTC2      BioGRID    PubMed
Affinity Capture-MS
  BioGRID:113364   BioGRID:115552   DENND4A      BioGRID    PubMed
Two-hybrid
  BioGRID:113364   BioGRID:118061   DISC1      BioGRID    PubMed
Affinity Capture-MS
  BioGRID:113364   BioGRID:123144   EDC3      BioGRID    PubMed
Affinity Capture-MS; Affinity Capture-Western; Reconstituted Complex; Two-hybrid
  BioGRID:113364   BioGRID:116753   EPB41L3      BioGRID    PubMed
Affinity Capture-MS
  BioGRID:113364   BioGRID:116714   ERC1      BioGRID    PubMed
Affinity Capture-MS
  BioGRID:113364   BioGRID:120476   FAM82A2      BioGRID    PubMed
Affinity Capture-Western
  BioGRID:113364   BioGRID:108597   FOXO1      BioGRID    PubMed
Affinity Capture-MS
  BioGRID:113364   BioGRID:130134   FRYL      BioGRID    PubMed
Affinity Capture-MS
  BioGRID:113364   BioGRID:114268   GBF1      BioGRID    PubMed
Reconstituted Complex
  BioGRID:113364   BioGRID:115106   HDAC4      BioGRID    PubMed
Affinity Capture-MS
  BioGRID:113364   BioGRID:109701   IGF1R      BioGRID    PubMed
Affinity Capture-MS
  BioGRID:113364   BioGRID:114209   IRS2      BioGRID    PubMed
Two-hybrid
  BioGRID:113364   BioGRID:115078   KIAA0408      BioGRID    PubMed
Affinity Capture-Western; Reconstituted Complex
  BioGRID:113364   BioGRID:115972   KIF1C      BioGRID    PubMed
Affinity Capture-MS
  BioGRID:113364   BioGRID:114873   KIF23      BioGRID    PubMed
Affinity Capture-MS
  BioGRID:113364   BioGRID:110000   KIF5B      BioGRID    PubMed
Affinity Capture-MS
  BioGRID:113364   BioGRID:110001   KIF5C      BioGRID    PubMed
Affinity Capture-MS
  BioGRID:113364   BioGRID:110029   KLC1      BioGRID    PubMed
Affinity Capture-MS
  BioGRID:113364   BioGRID:122313   KLC2      BioGRID    PubMed
Affinity Capture-MS
  BioGRID:113364   BioGRID:127078   KLC3      BioGRID    PubMed
Affinity Capture-MS
  BioGRID:113364   BioGRID:124648   KLC4      BioGRID    PubMed
Affinity Capture-MS
  BioGRID:113364   BioGRID:110079   KRT31      BioGRID    PubMed
Affinity Capture-MS
  BioGRID:113364   BioGRID:110082   KRT33B      BioGRID    PubMed
Affinity Capture-MS
  BioGRID:113364   BioGRID:110089   KRT85      BioGRID    PubMed
Affinity Capture-MS
  BioGRID:113364   BioGRID:116947   LARP1      BioGRID    PubMed
Affinity Capture-MS
  BioGRID:113364   BioGRID:110122   LBR      BioGRID    PubMed
Affinity Capture-MS
  BioGRID:113364   BioGRID:119646   LUC7L2      BioGRID    PubMed
Affinity Capture-MS
  BioGRID:113364   BioGRID:110379   MAP3K3      BioGRID    PubMed
Affinity Capture-MS
  BioGRID:113364   BioGRID:108326   MARK2      BioGRID    PubMed
Affinity Capture-MS
  BioGRID:113364   BioGRID:110310   MARK3      BioGRID    PubMed
Affinity Capture-MS
  BioGRID:113364   BioGRID:110447   MLLT4      BioGRID    PubMed
Affinity Capture-MS
  BioGRID:113364   BioGRID:116776   MPRIP      BioGRID    PubMed
Affinity Capture-MS
  BioGRID:113364   BioGRID:117497   OSBPL3      BioGRID    PubMed
Affinity Capture-MS
  BioGRID:113364   BioGRID:115586   PAK4      BioGRID    PubMed
Affinity Capture-MS
  BioGRID:113364   BioGRID:121134   PARD3      BioGRID    PubMed
Reconstituted Complex
  BioGRID:113364   BioGRID:111154   PCTK1      BioGRID    PubMed
Affinity Capture-MS
  BioGRID:113364   BioGRID:111316   PI4KB      BioGRID    PubMed
Affinity Capture-MS
  BioGRID:113364   BioGRID:114068   PPFIBP1      BioGRID    PubMed
Affinity Capture-Western
  BioGRID:113364   BioGRID:111564   PRKCA      BioGRID    PubMed
Affinity Capture-Western
  BioGRID:113364   BioGRID:111565   PRKCB      BioGRID    PubMed
Affinity Capture-Western
  BioGRID:113364   BioGRID:111566   PRKCD      BioGRID    PubMed
Affinity Capture-Western
  BioGRID:113364   BioGRID:111568   PRKCG      BioGRID    PubMed
Affinity Capture-Western
  BioGRID:113364   BioGRID:111574   PRKCQ      BioGRID    PubMed
Affinity Capture-Western
  BioGRID:113364   BioGRID:111576   PRKCZ      BioGRID    PubMed
Affinity Capture-MS
  BioGRID:113364   BioGRID:114416   PRPF4B      BioGRID    PubMed
Affinity Capture-MS
  BioGRID:113364   BioGRID:114583   RABEP1      BioGRID    PubMed
Affinity Capture-MS
  BioGRID:113364   BioGRID:118154   RABGEF1      BioGRID    PubMed
Affinity Capture-MS
  BioGRID:113364   BioGRID:118892   RACGAP1      BioGRID    PubMed
Affinity Capture-MS; Affinity Capture-Western
  BioGRID:113364   BioGRID:111831   RAF1      BioGRID    PubMed
Affinity Capture-MS
  BioGRID:113364   BioGRID:117526   RAI14      BioGRID    PubMed
Affinity Capture-MS
  BioGRID:113364   BioGRID:120407   SAMD4B      BioGRID    PubMed
Affinity Capture-MS
  BioGRID:113364   BioGRID:109072   SFN      BioGRID    PubMed
Affinity Capture-MS
  BioGRID:113364   BioGRID:122898   SHCBP1      BioGRID    PubMed
Affinity Capture-MS
  BioGRID:113364   BioGRID:116661   SNRNP200      BioGRID    PubMed
Affinity Capture-MS
  BioGRID:113364   BioGRID:112534   SON      BioGRID    PubMed
Affinity Capture-MS
  BioGRID:113364   BioGRID:117071   SRRM2      BioGRID    PubMed
Affinity Capture-MS
  BioGRID:113364   BioGRID:114809   TJP2      BioGRID    PubMed

[Top][Help]General gene information

Markers

D7S551E(e-PCR)
Links: UniSTS:20499
D7S2057E(e-PCR)
Links: UniSTS:151115
A002D37(e-PCR)
Links: UniSTS:51041
G19981(e-PCR)
Links: UniSTS:62820
GDB:1317208(e-PCR)
Links: UniSTS:56784
RH12457(e-PCR)
Links: UniSTS:78291
1138(e-PCR)
Links: UniSTS:26350
D7S1878E(e-PCR)
Links: UniSTS:473333

Homology

Homologs of the YWHAG gene The YWHAG gene is conserved in chimpanzee, dog, cow, mouse, rat, chicken, and zebrafish.


Map Viewer (Mouse, Rat)

Pathways

KEGG pathway: Cell cycle
04110
KEGG pathway: Neurotrophin signaling pathway
04722
Reactome Event:Cell Cycle, Mitotic
REACT_152

[Top][Help]General protein information

Preferred Names
tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma polypeptide
Names
tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma polypeptide
14-3-3 gamma

[Top][Help]NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

mRNA and Protein(s)

  1. NM_012479.3NP_036611.2  tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma polypeptide

    Source sequence(s)
    AB024334,AC006388,BC020963,BI495132,DC343104
    Consensus CDS
    CCDS5584.1
    UniProtKB/Swiss-Prot
    P61981
    Conserved Domains (1) summary
    cl02098
    Location:4235
    Blast Score: 1050
    14-3-3; 14-3-3 protein

RefSeqs of Annotated Genomes: Build 37.1

The following sections contain reference sequences that belong to a specific genome build. Explain

Genome Reference Consortium Human Build 37 (GRCh37), Primary_Assembly

Genomic

  1. NC_000007.13

    Range
    75956107..75988341, complement
    Download
    GenBank FASTA Sequence Viewer (Graphics)
  2. NT_007933.15 

    Range
    13988950..14021184, complement
    Download
    GenBank FASTA Sequence Viewer (Graphics)

Alternate assembly (Celera)

Genomic

  1. AC_000050.1

    Range
    70824627..70856861, complement
    Download
    GenBank FASTA Sequence Viewer (Graphics)
  2. NW_923484.1 

    Range
    821381..853615, complement
    Download
    GenBank FASTA Sequence Viewer (Graphics)

Alternate assembly (HuRef)

Genomic

  1. AC_000139.1

    Range
    71042474..71074828, complement
    Download
    GenBank FASTA Sequence Viewer (Graphics)
  2. NW_001839047.1 

    Range
    854614..886968, complement
    Download
    GenBank FASTA Sequence Viewer (Graphics)

Alternate assembly (CRA_TCAGchr7v2)

Genomic

  1. AC_000068.1

    Range
    75289171..75321405, complement
    Download
    GenBank FASTA Sequence Viewer (Graphics)
  2. NT_079595.2 

    Range
    1190383..1222617, complement
    Download
    GenBank FASTA Sequence Viewer (Graphics)

[Top][Help]Related Sequences

  Nucleotide   Protein
  genomic   AC005522.2  (142183..149404)   None
  genomic   AC006388.3   None
  genomic   CH471220.1   EAW71804.1
  mRNA   AB024334.1   BAA85184.1
  mRNA   AF142498.1   AAD48408.1
  mRNA   AK024230.1   BAG51276.1
  mRNA   AK293505.1   BAG56989.1
  mRNA   AK295029.1   BAG58085.1
  mRNA   BC020963.2   AAH20963.1
  mRNA   BI495132.1   None
  mRNA   CR541904.1   CAG46702.1
  mRNA   CR541925.1   CAG46723.1
  mRNA   CR598331.1   None
  mRNA   DC343104.1   None
Protein Accession   Links
P61981.2   GenPept   UniProtKB/Swiss-Prot:P61981

[Top][Help]Additional Links