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changes in the expression of five 14-3-3 isoforms (beta, gamma, epsilon, tau, and zeta) during the apoptosis of JURL-MK1 and K562 cells. |
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Observational study of gene-disease association. (HuGE Navigator) |
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A new regulatory mechanism of myosin light-chain phosphatase via the interaction between 14-3-3 and MYPT1, is reported. |
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Ror2 induces osteogenic differentiation, at least in part, through a release of the 14-3-3beta-mediated inhibition |
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PBF is a new cellular factor mediating the effects of PI3K/Akt signaling and 14-3-3 on cell growth |
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HS1 with EPEP insertion polymorphism transmits accelerated signals from B cell receptor and is involved in pathogenesis of systemic lupus erythematosus. |
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novel binding site on 14-3-3 for integrin beta1 and a functional amphipathic groove, rather than its interaction with integrin beta1, is required for 14-3-3 regulation of cell spreading and migration. |
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8. |
Immunoexpression of 14-3-3 proteins in glial cytoplasmic inclusions of multiple system atrophy. |
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14-3-3beta is a p90 ribosomal S6 kinase (RSK) isoform 1-binding protein that negatively regulates RSK kinase activity |
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10. |
14-3-3 binds to the IGF-1 receptor after IGF1R's serine autophosphorylation |
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11. |
14-3-3 beta interacts with the TSC1-TSC2 complex and negatively regulates the function of the TSC proteins |
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12. |
TSC2 associates with 14-3-3 in vivo |
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13. |
MK2 phosphorylates TSC2, which creates a 14-3-3 binding site and thus regulates the cellular function of the TSC2 tumor suppressor protein |
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14. |
decreased expression of selected 14-3-3 genes is a common feature of schizophrenia |
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15. |
These findings suggest that deregulation of 14-3-3 protein amounts might contribute to the development of tumors in tuberous sclerosis patients. |
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16. |
14-3-3beta binds DYRK1A |
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Results show that three 14-3-3 isoforms, beta, gamma and eta, are DAL-1/Protein 4.1B-binding proteins. |
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18. |
KCNK3 potassium channels are shown to bear two cytoplasmic trafficking motifs: an N-terminal dibasic site that binds beta-COP to hold channels in ER and a C-terminal "release" site that binds the ubiquitous intracellular regulator 14-3-3beta |
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19. |
These data show a novel interaction for 14-3-3 with NFL mRNA, and suggests that 14-3-3 may play a role in regulating NFL mRNA stability. |
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20. |
Tyrosine 3-monooxygenase/tryptophan S-monooxygenase activation protein, beta polypeptide is decreased during acute lung injury more in mice deficient in metallothionein 1/2 |