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These results suggest that SFK trafficking is specified by the palmitoylation state in the SH4 domain. |
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Observational study of gene-disease association. (HuGE Navigator) |
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Vascular endothelial growth factor (VEGF)-induced cell migration is significantly decreased in Yes-deficient retinal microvascular endothelial cells. |
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Binding of CD95 Ligand to CD95 on glioblastoma cells recruit Yes and the p85 subunit of phosphatidylinositol 3-kinase to CD95, which signal invasion via the glycogen synthase kinase 3-beta pathway and subsequent expression of matrix metalloproteinases. |
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Thus, these results suggest that endogenous c-Src, c-Yes, and Lyn are differentially activated through Cdc2 activation during M phase. |
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c-Yes induction results in increased colorectal carcinoma cell motility but did not promote proliferation. In later stages of colorectal carcinogenesis, elevations in c-Yes levels/activity may promote cancer spread & metastasis rather than tumor growth. |
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The results were confirmed at the level of mRNA and protein, and suggested that four genes (OPCML, RNASE1, YES1 and ACK1) could play a key role in the tumorigenesis and metastasis of gastric cancer. |
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This review summarizes the potential functions of c-Yes and its ability to modulate signals that are distinct from c-Src. |
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Src family kinase Yes triggers hyperosmotic activation of the epidermal growth factor receptor and CD95 |
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c-Yes 3'-UTR contains at least three newly identified adenine/uridine-rich elements (AREs) which are bound specifically by ARE-binding proteins HuR and AUF1. |
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activation of c-Yes is important for maintaining embryonic stem cells in an undifferentiated state |
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Nucleus-located c-Yes may be a useful marker to detect early-stage hepatocellular carcinoma. |
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cAMP activates while Ca(2+) inhibits human sperm c-yes kinase activity |
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NFAT1, a transcription factor connected with breast cancer metastasis, is activated by Wnt-5a through a Ca2+ signaling pathway in human breast epithelial cells which was simultaneously counteracted by a Wnt-5a-induced Yes/Cdc42 signaling pathway. |
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QM binds to c-yes at the SH3 domain in tumor cell lines |
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activation of the protooncogene product c-Yes may play a significant role in the malignant transformation of hepatocytes |
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Amyloid aggregation by an SH3 domain from the Src family. |