Official Symbol

ANAPC1provided by HGNC

Official Full Name

anaphase promoting complex subunit 1provided by HGNC

Primary Source

HGNC:19988

See related

Ensembl:ENSG00000153107; HPRD:09769; MIM:608473

Gene type

protein coding

RefSeq status

VALIDATED

Organism

Homo sapiens

Lineage

Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo

Also known as

APC1; MCPR; TSG24; ANAPC1

Summary

ANAPC1 is 1 of at least 10 subunits of the anaphase-promoting complex (APC), which functions at the metaphase-to-anaphase transition of the cell cycle and is regulated by spindle checkpoint proteins. The APC is an E3 ubiquitin ligase that targets cell cycle regulatory proteins for degradation by the proteasome, thereby allowing progression through the cell cycle.[supplied by OMIM]

(minus strand) Go to reference sequence detailsTry our new Sequence Viewer

chromosome: 2; Location: 2q12.1See ANAPC1 in MapViewer

Preferred Names

anaphase promoting complex subunit 1

Names

anaphase promoting complex subunit 1

anaphase-promoting complex 1 (meiotic checkpoint regulator)

NP_073153.1

3` partial

5` partial

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

1. NM_022662.2 → NP_073153.1  anaphase promoting complex subunit 1

   Source sequence(s)

   AJ278357,BC005089,BX282336

   Consensus CDS

   CCDS2093.1

   UniProtKB/Swiss-Prot

   Q9H1A4

RefSeqs of Annotated Genomes: Build 37.1

The following sections contain reference sequences that belong to a specific genome build. Explain

This section includes genomic Reference Sequences (RefSeqs) from all assemblies on which this gene is annotated, such as RefSeqs for chromosomes and scaffolds (contigs) from both reference and alternate assemblies. Model RNAs and proteins are also reported here.

Genome Reference Consortium Human Build 37 (GRCh37), Primary_Assembly

Genomic

1. NC_000002.11

   Range

   112526637..112641740, complement

   Download

   GenBank FASTA Sequence Viewer (Graphics)

2. NT_022135.16 

   Range

   2275300..2390403, complement

   Download

   GenBank FASTA Sequence Viewer (Graphics)

Alternate assembly (Celera)

Genomic

1. AC_000045.1

   Range

   106403648..106465405

   Download

   GenBank FASTA Sequence Viewer (Graphics)

2. NW_921451.1 

   Range

   461141..522898

   Download

   GenBank FASTA Sequence Viewer (Graphics)

3. NW_922585.1 

   Range

   1443..3976, complement

   Download

   GenBank FASTA Sequence Viewer (Graphics)

4. NW_925858.1 

   Range

   2666..5204, complement

   Download

   GenBank FASTA Sequence Viewer (Graphics)

5. NW_926363.1 

   Range

   1859..3271, complement

   Download

   GenBank FASTA Sequence Viewer (Graphics)

6. NW_926368.1 

   Range

   866..2786

   Download

   GenBank FASTA Sequence Viewer (Graphics)

Alternate assembly (HuRef)

Genomic

1. AC_000134.1

   Range

   105096024..105155075

   Download

   GenBank FASTA Sequence Viewer (Graphics)

2. NW_001838771.2 

   Range

   14189..17593

   Download

   GenBank FASTA Sequence Viewer (Graphics)

3. NW_001838840.2 

   Range

   482294..541345

   Download

   GenBank FASTA Sequence Viewer (Graphics)

4. NW_001842286.1 

   Range

   3174..14665, complement

   Download

   GenBank FASTA Sequence Viewer (Graphics)

5. NW_001842324.1 

   Range

   53..400

   Download

   GenBank FASTA Sequence Viewer (Graphics)