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1. |
AMPK activates FOXO3 by promoting its nuclear translocation by reducing reactive oxygen species levels. |
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2. |
Cellular polarity and energy metabolism are regulated through the conserved LKB1-AMPK signal transduction pathway. |
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3. |
inhibition of AMPK sensitizes cells to Fas-induced apoptosis via enhancement of ubiquitination and consequent proteasome degradation of the apoptosis inhibitory protein c-FLIP |
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4. |
AMP-activated protein kinase inhibits alkaline pH- and PKA-induced apical vacuolar H+-ATPase accumulation in epididymal clear cells. |
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5. |
Inactivation of AMPK alters gene expression and promotes growth of prostate cancer cells. |
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6. |
p53 activation may downregulate the AKT/mTOR pathway through a mechanism involving AMP kinase in mantle cell lymphoma |
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7. |
Regulation of erythrocyte survival by AMPK is reported. |
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8. |
AMP-activated protein kinase has a role in gene expression in single islet beta-cells [review] |
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9. |
Brief intense interval exercise activates AMPK and p38 MAPK signaling and increases the expression of PGC-1alpha in human skeletal muscle. |
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10. |
AMPK controls the molecular mechanism underlying the differential biological functions of JNK, providing a novel explanation for the antiapoptotic role of LKB1. |
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11. |
Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator) |
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12. |
Data suggest that increased expression of malonyl CoA decarboxylase, and the decreased expression of acetyl CoA carboxylase and 5'-AMP activated protein kinase are important regulators of the maturation of fatty acid oxidation in the newborn human heart. |
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13. |
These findings raise the possibility that glucose-induced changes in AMPK are linked to alterations in SIRT1 abundance and activity and possibly cellular redox state. |
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14. |
UVB irradfiation regulates COX2 mRNA stability through AMPK and HuR in human keratinocytes. |
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15. |
The proliferation potential of senescent human diploid fibroblasts can be modulated through the regulation of the AMPK signaling pathway. |
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16. |
AMP-activated protein kinase contributes to UV- and H2O2-induced apoptosis in human skin keratinocytes |
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17. |
Inhibition of SIRT1 in telomerase-immortalized human cells and hematopoietic stem cells obtained from SIRT1-deficient mice enhanced cell growth under normal and nutrient limiting conditions. |
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18. |
Results report that oxygen deprivation can activate the autophagic pathway in human cancer cell lines via AMPK activity, independent of HIF-1, BNIP3, and BNIP3L. |
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19. |
Akt and AMPK have roles in the pathway of hydrogen peroxide-activated endothelial nitric-oxide synthase phosphorylation and function |
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20. |
AMPK activated by fluid shear stress is a novel regulator of FoxO1a phosphorylation and protein levels. |
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21. |
the activities of AMP-activated protein kinase, protein kinase B, and mammalian target of rapamycin by limiting energy availability with 2-deoxyglucose |
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22. |
modulating basal AMPK and CAMKKB activity in the hypothalamus is essential for maintaining tight regulation of pathways contributing to food intake |
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23. |
AMPK inhibits TGFbeta-induced transcription downstream of Smad3 COOH-terminal phosphorylation and nuclear translocation |
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24. |
findings show that that a beta1(186-270)gamma1 complex can form in the absence of detectable alpha subunit and that beta1 Thr-263 and Tyr-267 are required for betagamma association but not alphabeta association |
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25. |
AMPK activity is a key determinant of HIF-1 functions in response to reactive oxygen species and may be involffed in HIF-1 regulatory mechanisms. |
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26. |
AMP-activated protein kinase (AMPK) regulates GLUT4 transcription through the histone deacetylase (HDAC)5 transcriptional repressor. |
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27. |
AMPK regulates the proteasomal activity under conditions of energy demand. |
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28. |
Grb2 functions as a factor which mediates phosphorylation of AMPK at Thr172. |
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29. |
Observational study of gene-disease association. (HuGE Navigator) |
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30. |
metformin-mediated AMPK activation leads to inhibition of mTOR and a reduction in translation initiation |
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31. |
regulation of FOXO3 by AMPK may play a crucial role in fine tuning gene expression programs that control energy balance and stress resistance in cells throughout life |
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32. |
These results suggest that activation of AMPK inhibits multiple myeloma (MM) cell growth despite stimulation with IL-6, IGF-1, or HS-5 stromal cell conditioned medium and represents a potential new target in the therapy of MM. |
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33. |
phosphatidylinositol 3-kinase/Akt signaling and induces apoptosis is inhibited by energy depletion via AMP-activated protein kinase-dependent phosphorylation of IRS-1 at Ser-794 |
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34. |
AMPK mediates IL-2 production by regulating NF-AT and AP-1activation during T cell stimulation. |
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35. |
Results suggest that FLCN, mutated in Birt-Hogg-Dube syndrome, and its interacting partner FNIP1 may be involved in energy and/or nutrient sensing through the AMPK and mTOR signaling pathways. |
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36. |
These results show that AICAR and insulin/IGF-1 regulate VEGF expression through different mechanisms. |
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37. |
it is likely that the AMPK-GDE association is a novel mechanism regulating AMPK activity and the resultant fatty acid oxidation and glucose uptake |
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38. |
These results suggested that the combination of 5-FU and genistein exert a novel chemotherapeutic effect in colon cancers, and AMPK may be a regulatory molecule of COX-2 expression, further implying its involvement in cytotoxicity caused by genistein. |
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39. |
AMPK phosphorylated TRIP6 in vitro at the N-terminus and the transcriptional co-activator properties of TRIP6 were enhanced by AMPK action. |
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40. |
analysis of a new model for AMPK heterotrimer structure where through its C terminus the beta-subunit binds to the alpha-subunit that, in turn, binds to the gamma-subunit |
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41. |
Reduced activation of AMPK by globular adiponectin in obese and obese type 2 diabetic subjects is not caused by reduced adiponectin receptor expression. |
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42. |
AMPK activation and a reduced phosphorylation of 4E-BP1 may contribute to the inhibition of muscle protein synthesis during resistance exercise. |
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43. |
These are the first data to show an effect of AMPK on cell movement, and suggest a fundamental role for energy deficiency in regulating cellular behaviour. |
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44. |
Endothelial cells possess two pathways to activate AMPK, one Ca2+/CaMKKbeta dependent and one AMP/LKB1 dependent. |
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45. |
5-Aminoimidazole-4-carboxamide riboside sensitizes TRAIL- and TNF{alpha}-induced cytotoxicity in colon cancer cells through AMP-activated protein kinase signaling |
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46. |
Dipyridamole, an adenosine transporter inhibitor, and 5'-amino-5'-deoxyadenosine, an adenosine kinase inhibitor, blocked the effect of AICAR on the down-regulation of the insulin receptor protein, mRNA, and promoter activity. |
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47. |
AMPK has a role in regulating growth of cultured human keratinocytes |
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48. |
In conclusion, during prolonged submaximal exercise at 60% VO2peak, higher fat oxidation in women cannot be explained by higher AMPK signalling. |
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49. |
modulation of AMPK activity did not affect PI3K/AKT signalling, an advantage for the potential use of AMPK as a target for cancer therapy in LKB1 wild-type tumours |
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50. |
These findings suggest that the activation of JAK2, but not STAT3, may play a critical role in leptin-induced AMPK activation in Huh7 cells. |